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Lifting-jacks. --- Vérins --- Plastics. --- Matières plastiques
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Poisonous snakes --- Venom --- Venomous snakes --- Vipers --- Poisonous animals --- Snakes --- Serps --- Verins animals --- Antídots --- Índia --- Verins --- Antitoxines --- Animals verinosos --- Ofidis --- Ophidia --- Serpentes --- Serpents --- Rèptils --- Colúbrids --- Vipèrids --- Bharat --- República de la India --- República de l'Índia --- Àsia del Sud --- Ajantha (Índia) --- Assam (Índia : Estat) --- Brahmaputra (Àsia : Curs d'aigua) --- Calcuta (Índia) --- Delhi (Índia) --- Kodagu (Índia : Regió) --- Goa (Índia : Estat) --- Jammu i Caixmir (Índia : Estat) --- Kerala (Índia : Estat) --- Madràs (Índia) --- Madhya Pradesh (Índia : Estat) --- Maharashtra (Índia : Estat) --- Orissa (Índia : Estat) --- Panjab (Índia : Estat) --- Rajasthan (Índia : Estat) --- Uttar Pradesh (Índia : Estat) --- Caixmir (Àsia : Regió)
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This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.
Toxicologia --- Intoxicació --- Manuals de laboratori --- Tècniques de laboratori --- Intoxicació alimentària --- Intoxicació plúmbica --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Verins --- Medicine—Research. --- Biology—Research. --- Biomedical Research. --- Xenobiòtics --- Efectes secundaris --- Efectes secundaris dels medicaments --- Bioquímica --- Productes químics
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Chemistry --- Chemistry. --- chemistry --- Physical sciences --- Química. --- Revistes electròniques. --- Revistes digitals --- Revistes en línia --- Revistes on line --- Revistes per Internet --- Publicacions electròniques --- Revistes --- Ciència --- Àcids --- Aire líquid --- Espectroscòpia --- Bases (Química) --- Bioquímica --- Catàlisi --- Color --- Combustió --- Condensació --- Cosmoquímica --- Cristal·lització --- Dissociació (Química) --- Electroquímica --- Elements químics --- Estereoquímica --- Evaporació --- Explosius --- Farmàcia --- Fermentació --- Foc --- Geoquímica --- Microquímica --- Nanoquímica --- Química agrícola --- Química ambiental --- Química analítica --- Química dental --- Química farmacèutica --- Química física --- Química inorgànica --- Química orgànica --- Química sanitària --- Reaccions químiques --- Sals --- Verins --- Ensenyament de la química --- Gastronomia molecular
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This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply both with scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.
Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Toxicologia --- Models matemàtics --- Models (Matemàtica) --- Models experimentals --- Models teòrics --- Mètodes de simulació --- Anàlisi de sistemes --- Mètode de Montecarlo --- Modelització multiescala --- Models economètrics --- Models lineals (Estadística) --- Models multinivell (Estadística) --- Models no lineals (Estadística) --- Programació (Ordinadors) --- Simulació per ordinador --- Teoria de màquines --- Models biològics --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins
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This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Analysis of Drugs of Abuse aims to ensure successful results in the further study of this vital field.
Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Toxicologia --- Drogoaddicció --- Manuals de laboratori --- Abús de les drogues --- Addicció a les drogues --- Consum de drogues --- Drogodependència --- Narcoticomania --- Toxicomania --- Conducta compulsiva --- Drogues --- Abús dels medicaments --- Al·lucinògens --- Alcoholisme --- Drogoaddicció en l'embaràs --- Drogoaddictes --- Drogues i escoles --- Drogues i joventut --- Estimulants --- Opiomania --- Síndrome d'abstinència --- Desintoxicació de les drogues --- Prevenció de toxicomanies --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Tècniques de laboratori
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This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.
Monoclonal antibodies. --- Biochemistry. --- Toxicology. --- Antibodies. --- Protein Science. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Toxicology --- Composition --- Anticossos monoclonals --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Immunoglobulines monoclonals --- Clonatge molecular --- Immunoglobulines --- Rituximab
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This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology. .
Pharmaceutical technology. --- Pharmacy. --- Drug resistance. --- Pharmaceutical Sciences/Technology. --- Drug Resistance. --- Toxicology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Physiological effect --- Toxicology --- Resistance to drugs --- Chemistry --- Materia medica --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Tecnologia farmacèutica --- Toxicologia --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia
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Apoptosis, or programmed cell death, is a widespread cellular process that regulates numerous important biological events ranging from the metamorphosis of the tadpole tail to the elimination of surplus brain cells in the formation of proper synaptic connections. In Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification, Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful in toxicology and pharmacology research. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high-throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems. Presented by authors well-versed in the technical problems and challenges in analyzing apoptosis, each method explicates its successful use, describes its limitations, and shows how it may be applied in large-scale screening operations. Concise and eminently practical, Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification offers pharmacologists, toxicologists, pathologists, and many other biomedical scientists today's gold standard reference source for methods that definitively identify and accurately quantify apoptosis.
Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Apoptosi --- Farmacologia --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Medicaments --- Quimioteràpia --- Mort cel·lular
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This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
Nanoparticles --- Human physiology. --- Nanotechnology. --- Toxicology. --- Molecular technology --- Nanoscale technology --- High technology --- Human biology --- Medical sciences --- Physiology --- Human body --- Nano-particles --- NPs (Nanoparticles) --- Nanoscale particles --- Nanostructured materials --- Particles --- Animal models in research. --- Pharmacology. --- Human Physiology. --- Animal Models. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Physiological effect --- Drosòfila --- Nanopartícules --- Toxicologia --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Materials nanoestructurats --- Partícules (Matèria) --- Nanocristalls --- Drosophila --- Drosofílids --- Drosòfila melanogaster --- Drosòfila subobscura --- Biology --- Experimental Organisms. --- Technique.
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