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This dissertation focuses on the assessment of ventricular function using 4D Flow CMR, a magnetic resonance imaging technique that captures three-dimensional, time-resolved velocity data of blood flow. It explores how changes in intracardiac blood flow patterns can indicate cardiac remodeling and dysfunction, particularly in congenital and acquired heart diseases. The research highlights the importance of early detection and treatment of heart conditions to prevent progression to heart failure. The study evaluates blood flow in both left and right ventricles, with significant findings related to turbulent kinetic energy and its impact on ventricular remodeling. The work is supported by various research foundations and aims to provide diagnostic insights for clinicians and researchers in cardiology.

Ventricular remodeling. --- Blood flow. --- Ventricular remodeling --- Blood flow

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Receptors, Adrenergic, beta-3 - therapeutic use --- Ventricular Remodeling

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Renin-Angiotensin System --- Myocardial Infarction --- Ventricular Remodeling --- physiology --- physiopathology

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Myocardial Infarction --- Ventricular Remodeling --- Insulin-Like Growth Factor I --- physiopathology --- physiology --- deficiency

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The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

Cardiology. --- Medicine. --- Ventricular remodeling. --- Ventricular remodeling --- Ventricular Function --- Pathological Conditions, Anatomical --- Cardiovascular Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Diseases --- Cardiovascular Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Ventricular Remodeling --- Medicine --- Health & Biological Sciences --- Pathology --- Cardiovascular Diseases --- Molecular aspects. --- Treatment. --- Cardiac remodeling, Ventricular --- Myocardial remodeling, Ventricular --- Remodeling, Ventricular --- Ventricle remodeling --- Ventricular cardiac remodeling --- Ventricular myocardial remodeling --- Human physiology. --- Molecular biology. --- Medical biochemistry. --- Biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Human Physiology. --- Molecular Medicine. --- Biochemistry, general. --- Myocardial infarction --- Complications --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Heart --- Internal medicine --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Clinical biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research