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A blueprint for the investigation of neurodevelopmental disorders, this book presents the work of a team of scientists using a multidisciplinary, integrated approach to link genes with human behavior. Using Williams syndrome as a model, leading researchers in neuroanatomy, neurocognition, neurophysiology, and molecular genetics have built bridges between disciplines to link higher cognitive functions, their underlying neurobiological bases, and their molecular genetic underpinnings. One of the book's many strengths is that the scientists from each discipline studied the same individuals with Williams syndrome. As the book shows, Williams syndrome is a fascinating disorder because of the "peaks and valleys" among cognitive domains: severe intellectual deficits but remarkably spared and effusive language; specific impairment in spatial construction but great strength in face processing and sociability. By capitalizing on these dissociations in higher cognitive functioning, the book provides a model for the study of brain-behavior relationships as well as for the mapping of brain and behavior phenotypes to the genome and beyond. Contributors Ralph Adolphs, Twyla Alvarez, Lawrence Appelbaum, Ursula Bellugi, Dennis Burian, Xiao-Ning Chen, Michael Chiles, Stephan Eliez, Albert Galaburda, Hanao Hirota, Wendy Jones, Julie Korenberg, Zona Lai, Liz Lichtenberger, Alan Lincoln, Rumiko Matsuoka, Debra Mills, Helen Neville, Judy Reilly, Allan Reiss, Bruce Roe, Marie St. George, J. Eric Schmidtt, Erica Straus.

Cognitive psychology --- Neuropathology --- Williams Syndrome --- Cognition --- Brain Diseases --- Aortic Stenosis, Supravalvular --- Mental Retardation --- Mental Processes --- Central Nervous System Diseases --- Chromosome Disorders --- Psychological Phenomena and Processes --- Congenital Abnormalities --- Genetic Diseases, Inborn --- Aortic Valve Stenosis --- Nervous System Diseases --- Neurobehavioral Manifestations --- Diseases --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Neurologic Manifestations --- Psychiatry and Psychology --- Heart Valve Diseases --- Heart Diseases --- Cardiovascular Diseases --- Pediatrics --- Medicine --- Health & Biological Sciences --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiac Diseases --- Cardiac Disease --- Disease, Cardiac --- Disease, Heart --- Diseases, Cardiac --- Diseases, Heart --- Heart Disease --- Valvular Heart Diseases --- Disease, Heart Valve --- Disease, Valvular Heart --- Diseases, Heart Valve --- Diseases, Valvular Heart --- Heart Disease, Valvular --- Heart Diseases, Valvular --- Heart Valve Disease --- Valve Disease, Heart --- Valve Diseases, Heart --- Valvular Heart Disease --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Cognitive Manifestations --- Neurobehavioral Signs and Symptoms --- Cognitive Symptoms --- Signs and Symptoms, Neurobehavioral --- Cognitive Manifestation --- Cognitive Symptom --- Manifestation, Cognitive --- Manifestation, Neurobehavioral --- Manifestations, Cognitive --- Manifestations, Neurobehavioral --- Neurobehavioral Manifestation --- Symptom, Cognitive --- Symptoms, Cognitive --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Aortic Stenosis --- Aortic Valve Stenoses --- Stenoses, Aortic --- Stenoses, Aortic Valve --- Stenosis, Aortic --- Stenosis, Aortic Valve --- Valve Stenoses, Aortic --- Valve Stenosis, Aortic --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Abnormalities, Congenital --- Defects, Congenital --- Birth Defects --- Congenital Defects --- Deformities --- Abnormality, Congenital --- Birth Defect --- Congenital Abnormality --- Congenital Defect --- Defect, Birth --- Defect, Congenital --- Defects, Birth --- Deformity --- Psychologic Processes and Principles --- Chromosomal Disorders --- Autosomal Chromosome Disorders --- Chromosome Abnormality Disorders --- Autosomal Chromosome Disorder --- Chromosomal Disorder --- Chromosome Abnormality Disorder --- Chromosome Disorder --- Chromosome Disorder, Autosomal --- Chromosome Disorders, Autosomal --- Disorder, Chromosomal --- Disorder, Chromosome --- Disorder, Chromosome Abnormality --- Disorders, Chromosomal --- Disorders, Chromosome --- CNS Diseases --- Central Nervous System Disorders --- CNS Disease --- Human Information Processing --- Information Processing, Human --- Deficiency, Mental --- Intellectual Development Disorder --- Mental Deficiency --- Mental Retardation, Psychosocial --- Disability, Intellectual --- Idiocy --- Retardation, Mental --- Deficiencies, Mental --- Development Disorder, Intellectual --- Development Disorders, Intellectual --- Disabilities, Intellectual --- Disorder, Intellectual Development --- Disorders, Intellectual Development --- Intellectual Development Disorders --- Intellectual Disabilities --- Mental Deficiencies --- Mental Retardations, Psychosocial --- Psychosocial Mental Retardation --- Psychosocial Mental Retardations --- Retardation, Psychosocial Mental --- Retardations, Psychosocial Mental --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Cognitive Function --- Cognitions --- Cognitive Functions --- Function, Cognitive --- Functions, Cognitive --- Beuren Syndrome --- Chromosome 7q11.23 Deletion Syndrome --- Hypercalcemia-Supravalvar Aortic Stenosis --- Supravalvar Aortic Stenosis Syndrome --- Williams Contiguous Gene Syndrome --- Williams-Beuren Syndrome --- Contiguous Gene Syndrome, Williams --- Aortic Stenoses, Hypercalcemia-Supravalvar --- Aortic Stenosis, Hypercalcemia-Supravalvar --- Hypercalcemia Supravalvar Aortic Stenosis --- Hypercalcemia-Supravalvar Aortic Stenoses --- Stenoses, Hypercalcemia-Supravalvar Aortic --- Stenosis, Hypercalcemia-Supravalvar Aortic --- Syndrome, Beuren --- Syndrome, Williams --- Syndrome, Williams-Beuren --- Williams Beuren Syndrome --- Aortic Supravalvular Stenosis --- Stenosis, Aortic Supravalvular --- Stenosis, Supravalvular Aortic --- Supravalvar Aortic Stenosis --- Supravalvular Stenosis, Aortic --- Supravalvular Aortic Stenosis --- Aortic Supravalvular Stenoses --- Stenoses, Aortic Supravalvular --- Supravalvular Stenoses, Aortic --- Williams syndrome --- Cognition disorders in children. --- Brain --- Child psychiatry --- Child psychopathology --- Cognition in children --- Beuren syndrome --- Contiguous gene syndrome --- Elfin facies syndrome --- Fanconi-Schlesinger syndrome --- Idiopathic hypercalcemia-supravalvular aortic stenosis syndrome --- Supravalvar aortic stenosis syndrome --- Williams-Barratt syndrome --- Williams-Beuren syndrome --- Williams contiguous gene syndrome --- Aortic valve stenosis in children --- Intellectual disability --- Syndromes in children --- Pathophysiology. --- Genetic aspects. --- genetics. --- physiology. --- pathology. --- physiopathology. --- psychology. --- NEUROSCIENCE/General