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Vaccines. --- Drug development. --- Vaccines industry. --- Vaccine industry --- Pharmaceutical industry --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Biologicals --- Development --- Vaccines --- Biotechnology. --- Vaccine biotechnology --- Biotechnology

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This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.

Varicella-zoster virus. --- Chickenpox virus --- Herpes zoster virus --- Human herpesvirus-3 --- Varicella virus --- VZ virus --- Herpesviruses --- Virology. --- Immunology. --- Human physiology. --- Vaccines --- Biomaterials. --- Human Physiology. --- Biomaterials-Vaccines. --- Biotechnology. --- Vaccine biotechnology --- Biotechnology --- Human biology --- Medical sciences --- Physiology --- Human body --- Immunobiology --- Life sciences --- Serology --- Microbiology --- Biomedical materials.

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Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View provides an integrated outlook of the disciplines involved in the development of plant-based vaccines as well as an updated compilation of the successful developments in the field. The volume covers immunological aspects of mucosal vaccine design, molecular approaches to attain high levels of the recombinant antigens, the rationale of using bioreactor to expand plant biomass, and pharmaceutical technology approaches that have been applied to the development of plant-based vaccine formulations. Practical figures and tables are presented to facilitate reading and identification of key points. Perspectives for this field are also discussed. Written by authorities in the field, Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View is a comprehensive resource for researchers and students interested in plant genetics and breeding, immunology, and genetic engineering.

Vaccines --- Transgenic plants --- Plant genetic engineering. --- Biotechnology. --- Therapeutic use. --- Plants --- Genetic engineering --- Plant biotechnology --- GE crops (Genetically engineered crops) --- GE plants (Genetically engineered plants) --- Genetically engineered crops --- Genetically engineered plants --- Genetically modified crops --- Genetically modified plants --- GM crops (Genetically modified crops) --- GM plants (Genetically modified plants) --- Novel crops --- Transgenic crops --- Plants, Cultivated --- Transgenic organisms --- Plant genetic engineering --- Vaccine biotechnology --- Biotechnology --- Plant genetics. --- Plant breeding. --- Botany. --- Plant Genetics and Genomics. --- Plant Breeding/Biotechnology. --- Plant Sciences. --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Biology --- Natural history --- Crops --- Agriculture --- Breeding --- Genetics --- Plant science. --- Floristic botany

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This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.

Medicine—Research. --- Biology—Research. --- Drug delivery systems. --- Vaccines—Biotechnology. --- Biomaterials. --- Immunotherapy. --- Biomedical Research. --- Drug Delivery. --- Biomaterials-Vaccines. --- Therapeutic immunology --- Clinical immunology --- Therapeutics --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Delivery systems --- Drug Delivery Systems. --- Vaccines. --- Spray Drying. --- Drying, Spray --- Spray Dryings --- Immunotherapies --- Combined Antibody Therapeutics --- Immunity, Active --- Immunologic Techniques --- Vaccine --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Dosage Forms --- Spray drying. --- Vaccines --- Biotechnology. --- Vaccine biotechnology --- Biotechnology --- Drying --- Spraying

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This open access book is a collection of research papers on COVID-19 by Germán Velásquez from 2020 and early 2021 that help to answer the question: How can an agency like the World Health Organization (WHO) be given a stronger voice to exercise authority and leadership? The considerable health, economic and social challenges that the world faced at the beginning of 2020 with COVID-19 continued and worsened in many parts of the world in the second-half of 2020 and into 2021. Many of these countries and nations wanted to explore COVID-19 on their own, sometimes without listening to the main international health bodies such as WHO, an agency of the United Nations system with long-standing experience and vast knowledge at the global level and of which all countries in the world are members. In this single volume, the chapters present the progress of thinking and debate — particularly in relation to drugs and vaccines — that would enable a response to the COVID-19 pandemic or to subsequent crises that may arise. Among the topics covered: COVID-19 Vaccines: Between Ethics, Health and Economics Medicines and Intellectual Property: 10 Years of the WHO Global Strategy Re-thinking Global and Local Manufacturing of Medical Products After COVID-19 Rethinking R&D for Pharmaceutical Products After the Novel Coronavirus COVID-19 Shock Intellectual Property and Access to Medicines and Vaccines The World Health Organization Reforms in the Time of COVID-19 Vaccines, Medicines and COVID-19: How Can WHO Be Given a Stronger Voice? is essential reading for negotiators from the 194 member countries of the World Health Organization (WHO); World Trade Organization (WTO) and World Intellectual Property Organization (WIPO) staff participating in these negotiations; academics and students of public health, medicine, health sciences, law, sociology and political science; and intergovernmental organizations and non-governmental organizations that follow the issue of access to treatments and vaccines for COVID-19.

COVID-19 (Disease) --- Medical policy. --- Vaccines. --- Social aspects. --- 2019-nCoV disease --- 2019 novel coronavirus disease --- Coronavirus disease-19 --- Coronavirus disease 2019 --- COVID-19 virus disease --- COVID19 (Disease) --- Novel coronavirus disease, 2019 --- SARS coronavirus 2 disease --- SARS-CoV-2 disease --- Coronavirus infections --- Respiratory infections --- Biologicals --- Health care policy --- Health policy --- Medical care --- Medicine and state --- Policy, Medical --- Public health --- Public health policy --- State and medicine --- Science and state --- Social policy --- Government policy --- COVID-19 Coronavirus pandemic --- access to affordable essential medicines --- Vaccine nationalism and vaccine safety --- World Health Organization reform --- Biosimilars and biotherapeutics --- COVAX Facility --- COVID-19 diagnostics --- Global health preparedness --- Article 19 of the WHO Constitution --- access to COVID-19 tools (ACT) accelerator --- Framework Convention on Tobacco Control (FCTC) --- Inter-Governmental Working Group (IGWG) --- Patentability criteria --- Pharmaceutical sovereignty --- Research and Development (R&D) --- Universal Health Coverage (UHC) --- World Health Assembly (WHA) --- World Trade Organization (WTO) --- non-governmental organization (NGOs) --- Open Access --- Medicine, Preventive. --- Health promotion. --- Vaccines --- Biomaterials. --- Public health. --- Health Promotion and Disease Prevention. --- Health Policy. --- Biomaterials-Vaccines. --- Public Health. --- Biotechnology. --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Vaccine biotechnology --- Biotechnology --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Disease prevention --- Diseases --- Prevention of disease --- Preventive medicine --- Pathology --- Preventive medicine physicians --- Prevention --- COVID-19 Pandemic, 2020 --- -Political aspects.