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v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.
DNA-binding proteins. --- Genetic recombination. --- Genetic recombination --- DNA-binding proteins --- VDJ Recombinases --- Recombination, Genetic --- Recombinant Proteins --- DNA-Binding Proteins --- Nucleotidyltransferases --- Proteins --- Recombinases --- Genetic Processes --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Enzymes --- Phosphotransferases --- Enzymes and Coenzymes --- Transferases --- Chemicals and Drugs --- Phenomena and Processes --- Medical Research --- Genetics --- Medicine --- Biology --- Health & Biological Sciences --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosomes --- Recombinant DNA --- Health Workforce --- Biomedicine, general.
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Cytogenetics --- Cells --- Molecular genetics --- Genes --- Molecular biology --- Cytology --- Biomechanics --- Cell Division --- Gene Expression --- Gene Rearrangement --- Molecular Biology --- Signal Transduction --- Mechanical properties --- Biomechanics. --- Cytogenetics. --- Cytology. --- Genes. --- Molecular biology. --- Molecular genetics. --- Biologie moléculaire. --- Cytologie. --- Signal Transduction. --- Mechanical properties. --- Cell Division. --- Cells. --- Gene Expression. --- Gene Rearrangement. --- Molecular Biology. --- Histology. --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Cistron --- Gene --- Genetic Materials --- Cistrons --- Genetic Material --- Material, Genetic --- Materials, Genetic --- Biological mechanics --- Mechanical properties of biological structures --- DNA Rearrangement --- DNA Rearrangements --- Gene Rearrangements --- Rearrangement, DNA --- Rearrangement, Gene --- Rearrangements, DNA --- Rearrangements, Gene --- Molecular biochemistry --- Molecular biophysics --- Units of heredity --- Units of inheritance --- Cell biology --- Cellular biology --- Cell mechanics --- Cellular mechanics --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Cell --- Cell Division Phase --- Cell Divisions --- M Phase --- Division Phase, Cell --- Division, Cell --- Divisions, Cell --- M Phases --- Phase, Cell Division --- Phase, M --- Phases, M --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Genetic Phenomena --- Genome --- VDJ Recombinases --- Gene Expression Profiling --- Cell Biology --- Cleavage Stage, Ovum --- Biophysics --- Mechanics --- Contractility (Biology) --- Genetics --- Biochemistry --- Biomolecules --- Systems biology --- Heredity --- DNA --- Biology --- Cytologists --- Organisms --- Biologie moléculaire. --- Cell Signaling --- Gene expression. --- Gene rearrangement. --- Cellular signal transduction. --- Cytogénétique --- Cellules --- Génétique moléculaire --- Gènes --- Biologie moléculaire --- Cytologie --- Biomécanique --- Cellules. --- Expression génique. --- Réarrangement des gènes. --- Gènes. --- Transduction du signal cellulaire. --- Propriétés mécaniques --- Genetic regulation --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- DNA rearrangement --- Antibody diversity --- Expression
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