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This publication by the World Health Organization provides regulatory guidance for the assessment and management of applications for marketing authorization of oxytocin products. It addresses issues related to the quality of oxytocin, particularly in low and middle-income countries, where inferior quality products can lead to serious medical consequences, such as postpartum hemorrhage. The document outlines the technical information, stability, degradation, and production factors impacting oxytocin manufacturing. It is intended for healthcare authorities and stakeholders involved in pharmaceutical regulation, offering insights into ensuring the availability of high-quality oxytocin as a critical medication for maternal health.

Oxytocin. --- Uterine hemorrhage.

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Delivery (Obstetrics). --- Delivery, Obstetric. --- Délivrance (Obstétrique). --- Uterine Hemorrhage. --- Uterine hemorrhage. --- Utérus --- Hémorragie.

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Although disorders of the coagulation system are uncommon in pregnancy, the two main hazards - haemorrhage and thromboembolism - are leading causes of direct maternal death in the UK and worldwide. Gynaecologists may encounter abnormal haemostasis as a cause of intractable menorrhagia or perioperative haemorrhage, and thromboembolism is a significant risk for women undergoing major gynaecological surgery. This book brings together various aspects of haemostasis in relation to obstetrics and gynaecology to provide practical guidance to clinicians, who may only occasionally encounter these problems. Emphasis is placed on the need for good working relationships and close liaison between obstetricians and gynaecologists, anaesthetists, haematologists and blood transfusion services. The book is primarily designed to provide a comprehensive summary for candidates preparing for the Part 2 MRCOG examination, and as such covers the RCOG curriculum for haemorrhage and thrombosis. It is also a valuable guide for all healthcare professionals working in the field.

Blood coagulation disorders in pregnancy. --- Uterine hemorrhage. --- Thromboembolism.

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Menorrhagia --- Hypermenorrhea --- Uterine Hemorrhage --- Conferences - Meetings --- Uterine hemorrhage --- Hemorrhage, Uterine --- Uterus --- Hemorrhage --- Labor (Obstetrics) --- Chemotherapy --- Complications --- Diseases --- Heavy Menstrual Bleeding --- Heavy Periods --- Heavy Period --- Menstrual Bleeding, Heavy

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Uterus --- Intrauterine Devices --- Physical Examination --- Contrast Media --- Uterine Hemorrhage --- Sodium Chloride --- ultrasonography --- standards --- ultrasonography --- diagnostic use