Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Brucellosis is a major zoonotic disease that may cause a serious illness in humans and animals. Global prevalence of human brucellosis remains significant. More than half a million new brucellosis cases from 100 countries are reported annually to the World Health Organization (WHO). The majority of these cases are reported in developing countries.In humans, brucellosis (undulant fever, Malta fever) is characterized by an acute bacteremic phase followed by a chronic stage that may extend over many years and may involve many tissues. It is a systemic disease, and many organ systems (nervous system, heart, skeletal system, bone marrow, etc.) may become involved following hematogenous dissemination. Although eradicated in some countries, it remains one of the most economically important zoonosis worldwide as it is responsible for huge economic losses as well as significant human morbidity in endemic areas. Because of the nonspecific clinical manifestations of human brucellosis and the need for prolonged combination therapy with antibiotics that are not routinely prescribed for other infectious diseases, laboratory confirmation of the diagnosis is of paramount importance for adequate patient management. In addition, evidence of brucellosis has serious public health implications because it discloses exposure to a contaminated source (infected animals or their products, unsafe laboratory practices, or a potential biological warfare attack). This book addresses human brucellosis with stress on symptoms including those related to the less recognized disease localizations, risk of exposure, treatment, and prevention. Light is shed on animal brucellosis as it pertains to human exposure. The book also emphasizes on laboratory procedures in culturing and serologic techniques. Epidemiologic surveillance is among this books subjects as well as veterinary control measures.

Brucellosis. --- Brucelliasis --- Malta fever --- Rock fever --- Undulant fever --- Gram-negative bacterial infections --- Infectious & contagious diseases

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Brucellosis. --- Foodborne diseases. --- Food-borne diseases --- Foodborne illnesses --- Communicable diseases --- Brucelliasis --- Malta fever --- Rock fever --- Undulant fever --- Gram-negative bacterial infections

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

"Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria's virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules"--

Brucella melitensis. --- Brucellosis. --- Brucella Infection --- Brucellosis, Pulmonary --- Cyprus Fever --- Gibraltar Fever --- Rock Fever --- Malta Fever --- Undulant Fever --- Brucella Infections --- Brucelloses --- Brucelloses, Pulmonary --- Fever, Cyprus --- Fever, Gibraltar --- Fever, Malta --- Fever, Rock --- Fever, Undulant --- Infection, Brucella --- Pulmonary Brucelloses --- Pulmonary Brucellosis --- Brucella streptococcus miletensis --- Micrococcus melitensis --- Brucella --- Brucellosis in goats --- Brucellosis in sheep

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book provides an in-depth review of knowledge of neurobrucellosis, which remains common despite significant improvements in preventive measures, neuroradiological techniques, and treatment methods. The chapters are organized into five sections, the first three of which address cranial and intracranial brucellosis, spinal brucellosis, and brucellosis of the peripheral portions of the nervous system. The fourth section focuses on laboratory studies in neurobrucellosis, and the closing section is devoted to therapy, encompassing both medical approaches and the surgical procedures used to treat the complications associated with brucellosis involving the spine, brain, and peripheral nerves. Despite the impressive efforts to eradicate the disease, brucellosis still poses a great threat in the Mediterranean Basin, where it originated, as well as in South and Central America, the Caribbean, and Africa. Written and edited by leading international authorities in the field, this comprehensive book will be an ideal up-to-date reference for neurosurgeons, neurologists, and specialists in infectious disease who are seeking either basic or more advanced information on the disease and its diagnosis and treatment.

Surgery - General and By Type --- Surgery & Anesthesiology --- Health & Biological Sciences --- Brucellosis. --- Brucelliasis --- Malta fever --- Rock fever --- Undulant fever --- Gram-negative bacterial infections --- Neurosurgery. --- Neurology. --- Emerging infectious diseases. --- Radiology, Medical. --- Infectious Diseases. --- Neuroradiology. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Nervous system --- Neuropsychiatry --- Nerves --- Neurosurgery --- Diseases --- Surgery --- Neurology . --- Infectious diseases. --- Neuroradiography --- Neuroradiology --- Infection --- Infectious diseases --- Medical microbiology --- Causes and theories of causation --- Infection. --- Surgery. --- Radiography.