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Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational” diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book. Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book. Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Prion diseases. --- Encephalopathies, Spongiform --- Prion infections --- Spongiform encephalopathies --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Communicable diseases --- Slow virus diseases --- Proteomics. --- Molecular biology --- Proteins

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The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Prion diseases. --- Encephalopathies, Spongiform --- Prion infections --- Spongiform encephalopathies --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Communicable diseases --- Slow virus diseases --- Infectious & contagious diseases

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Prion diseases --- Prions --- Infectious protein particles --- Prion proteins --- Protein particles, Infectious --- Proteinaceous infection particles --- PrP proteins --- Proteins --- Encephalopathies, Spongiform --- Prion infections --- Spongiform encephalopathies --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Communicable diseases --- Slow virus diseases

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"Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeld-Jakob disease to Parkinson's, Alzheimer's, Lou Gehrig's, and others. As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind's most destructive diseases"--Provided by publisher.

Prions. --- Prion diseases. --- Encephalopathies, Spongiform --- Prion infections --- Spongiform encephalopathies --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Communicable diseases --- Slow virus diseases --- Infectious protein particles --- Prion proteins --- Protein particles, Infectious --- Proteinaceous infection particles --- PrP proteins --- Proteins

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Animaux [Maladies à prions chez les ] --- Dieren [Prionziekten bij de ] --- Encepholopathies [Spongiform ] --- Maladies à prions --- Maladies à prions chez les animaux --- Prion diseases --- Prion diseases in animals --- Prion infections --- Prions [Maladies à ] --- Prionziekten --- Prionziekten bij de dieren --- Spongiform encephalopathies --- Transmissible spongiform encephalopathies --- Unconventional slow virus diseases --- Ziekten [Prion] --- Prion diseases. --- Prion disease in animals.