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Ubiquitins --- Protein Binding --- Proteins --- physiology --- metabolism

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Amino Acids, Peptides, and Proteins. --- Chemical Phenomena. --- Proteins. --- Ubiquitins.

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The targeted addition of ubiquitin to proteins is now known to regulate many cellular events, with the enzymes involved in protein ubiquitination linked to a variety of clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome Protocols, hands-on leaders in the field, many of whom originally developed the methods they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome- dependent functions. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Electronic books. -- local. --- Proteolytic enzymes -- Laboratory manuals. --- Ubiquitin -- Laboratory manuals. --- Multienzyme Complexes --- Ubiquitin --- Cysteine Endopeptidases --- Multiprotein Complexes --- Enzymes --- Cysteine Proteases --- Ubiquitins --- Endopeptidases --- Peptide Hydrolases --- Macromolecular Substances --- Proteins --- Enzymes and Coenzymes --- Hydrolases --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Proteolytic enzymes --- Cysteine Endopeptidases. --- Multienzyme Complexes. --- Ubiquitine --- Enzymes protéolytiques --- metabolism. --- Laboratory manuals --- Manuels de laboratoire --- EPUB-LIV-FT SPRINGER-B LIVBIOLO --- Peptide hydrolases --- Proteases --- High mobility protein 20 --- HMP-20 --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Laboratory manuals.

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The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.

Ubiquitin. --- Ubiquitin --- Proteasome Endopeptidase Complex --- Ubiquitins --- Peptide Hydrolases --- Multienzyme Complexes --- Proteins --- Enzymes --- Hydrolases --- Multiprotein Complexes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Macromolecular Substances --- Enzymes and Coenzymes --- Animal Biochemistry --- Pathology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- High mobility protein 20 --- HMP-20 --- Medicine. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Biomedicine general. --- Medicine/Public Health, general. --- Biochemistry. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Health Workforce --- Biomedicine, general. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Clinical biochemistry.

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Proteomics --- Proteins --- Biochemistry --- Proteome. --- Protéines --- Biochimie --- Biochemistry. --- Proteomics. --- Research --- genetics. --- Recherche --- Research. --- Protein research --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Proteomes --- Proteids --- Composition --- Protéines --- Molecular biology --- Biology --- Chemistry --- Medical sciences --- Biomolecules --- Polypeptides --- Health Sciences --- Physiology --- Proteome --- proteome. --- proteins. --- genetics --- Biological Sciences --- animal genetics --- cytogenetics --- gender --- genetic equilibrium --- genetic factors --- genetic relationships --- genetic selection --- genetic stability --- genetic structure --- genetic traits --- genetic vectors --- genomics --- human genetics --- immunogenetics --- inheritance (genetics) --- landscape genetics --- maternal effect --- metabolomics --- microbial genetics --- molecular genetics --- nutrigenomics --- paternal effect --- phenomics --- phenotype --- plant genetics --- population genetics --- proteomics --- quantitative genetics --- reproductive fitness --- sex determination --- transcriptomics --- biotechnology --- breeding --- genetic models --- genetic resources --- geneticists --- amino acids, peptides and proteins --- advanced glycation end products --- advanced oxidation protein products --- agglutinins --- algal proteins --- angiogenic proteins --- animal proteins --- antifreeze proteins --- antimicrobial proteins --- apoproteins --- binding proteins --- BTB-Kelch proteins --- chloroplast proteins --- conjugated proteins --- contractile proteins --- CRISPR-associated proteins --- crystal proteins --- crystallins --- cytoskeletal proteins --- gelatin --- GTPase-activating proteins --- helminth proteins --- heme proteins --- insecticidal proteins --- kinesin --- lectins --- luminescent proteins --- membrane proteins --- microbial proteins --- mitochondrial proteins --- molecular chaperones --- molecular motor proteins --- multiprotein complexes --- neoplasm proteins --- nuclear-encoded proteins --- nuclear proteins --- nucleoproteins --- peptones --- phosphoproteins --- phytohemagglutinin --- plant proteins --- polyproteins --- prions --- protein aggregates --- protein corona --- protein products --- protozoan proteins --- pulmonary surfactant associated proteins --- receptors --- recombinant proteins --- regulatory proteins --- ribonucleoproteins --- ribosomal proteins --- scaffolding proteins --- scleroproteins --- selenoproteins --- seminal plasma proteins --- silver proteins --- simple proteins --- storage proteins --- structural proteins --- sulfur proteins --- surface proteins --- thermostable proteins --- transcobalamins --- transcription factors --- tubulin --- ubiquitins --- viral proteins --- protein sweeteners --- proteinuria --- proteolytic bacteria --- proteome --- phosphoproteome --- metabolome --- proteins --- sialome --- biochemistry --- molecular biology --- proteomics --- protein science --- systems biology --- bioinformatics --- Protéomique --- Protéomes.