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† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18.

Post-translational modification. --- Ubiquitin. --- Ubiquitin --- Post-translational modification --- Metabolic Phenomena --- Protein Processing, Post-Translational --- Proteins --- Ligases --- Protein Modification, Translational --- Enzymes --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Protein Biosynthesis --- Enzymes and Coenzymes --- Biochemical Processes --- Gene Expression Regulation --- Chemicals and Drugs --- Peptide Biosynthesis --- Chemical Processes --- Genetic Processes --- Biochemical Phenomena --- Genetic Phenomena --- Chemical Phenomena --- Ubiquitination --- Ubiquitin-Protein Ligase Complexes --- Metabolism --- Ubiquitins --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biophysics --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- High mobility protein 20 --- HMP-20 --- Life sciences. --- Human physiology. --- Molecular biology. --- Proteins. --- Life Sciences. --- Protein Science. --- Human Physiology. --- Molecular Medicine. --- Genetic translation --- Synthesis --- Biochemistry. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Medicine --- Protein Biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research