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This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

Molecular biology. --- Posttranslational modification. --- Cell biology. --- Molecular Medicine. --- Posttranslational Modification. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Genetic translation --- Proteins --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Synthesis --- Ligases. --- Synthetases --- Enzymes --- Ubiquitin-Protein Ligase Complexes. --- Ubiquitination. --- Ubiquitylation --- Ubiquitinated Proteins --- Endoplasmic Reticulum-Associated Degradation --- Complexes, Ubiquitin-Protein Ligase --- Ligase Complexes, Ubiquitin-Protein --- Ubiquitin Protein Ligase Complexes --- Proteasome Endopeptidase Complex --- Synthetase

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† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18.

Post-translational modification. --- Ubiquitin. --- Ubiquitin --- Post-translational modification --- Metabolic Phenomena --- Protein Processing, Post-Translational --- Proteins --- Ligases --- Protein Modification, Translational --- Enzymes --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Protein Biosynthesis --- Enzymes and Coenzymes --- Biochemical Processes --- Gene Expression Regulation --- Chemicals and Drugs --- Peptide Biosynthesis --- Chemical Processes --- Genetic Processes --- Biochemical Phenomena --- Genetic Phenomena --- Chemical Phenomena --- Ubiquitination --- Ubiquitin-Protein Ligase Complexes --- Metabolism --- Ubiquitins --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Biophysics --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- High mobility protein 20 --- HMP-20 --- Life sciences. --- Human physiology. --- Molecular biology. --- Proteins. --- Life Sciences. --- Protein Science. --- Human Physiology. --- Molecular Medicine. --- Genetic translation --- Synthesis --- Biochemistry. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Physiology --- Human body --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics --- Medicine --- Protein Biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research