Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Cancer—Animal models. --- Tumors—Classification. --- Tumors—Immunological aspects. --- Cancer Models. --- Cancer Staging. --- Tumour Immunology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.

Cancer --- Chemokines --- Cytokines Therapeutic use. --- Chemotherapy. --- Therapeutic use. --- Cancer. --- Tumors --- Therapeutics. --- Cancers. --- Tumour Immunology. --- Immunological aspects. --- Neoplasms. --- Chemokines. --- Cytokines.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

Cancer. --- Cancer --- Oncology. --- Immunotherapy. --- Tumors --- Nanomedicine. --- Cancer Biology. --- Cancer Therapy. --- Tumour Immunology. --- Cancer Nanotechnology. --- Treatment. --- Immunological aspects. --- Gastrointestinal Neoplasms. --- Tumor Microenvironment. --- Gastrointestinal system

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.

Cancer. --- Tumors. --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Medicine—Research. --- Biology—Research. --- Tumors—Immunological aspects. --- Biomedical Research. --- Cancer Biology. --- Cancer Microenvironment. --- Tumour Immunology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Tumors --- Neoplasms --- Immunotherapy. --- Immunological aspects --- therapy. --- Immunotherapies --- Tumours --- Immunological aspects. --- Pathology --- Cysts (Pathology) --- Oncology --- Tumor immunology --- Immunity, Active --- Immunologic Techniques --- Immunotherapy --- therapy --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- oncology --- immunology --- immunotherapy --- tumour immunology --- Combined Antibody Therapeutics