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This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.
Cancer—Animal models. --- Tumors—Classification. --- Tumors—Immunological aspects. --- Cancer Models. --- Cancer Staging. --- Tumour Immunology.
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This book provides insight into the various immunotherapeutic approaches for the treatment of lung cancers. The chapters of the book discuss the detailed mechanisms of checkpoint inhibitors, co-stimulatory molecules, drugs working in the immunosuppressive environment, and various vaccines for lung cancer. A chapter of the book explores the recent applications of the oncolytic virus in lung cancer treatment and discusses the potential and direction of oncolytic virus-based therapeutic vaccines. The chapter also elucidates the current understanding of the role of Toll-Like Receptors (TLRs) in tumor progression, and the recent progress in utilizing TLR agonists as potential therapeutic agents in lung cancer treatment. Towards the end, the book reviews the applications of stereotactic body radiation therapy (SBRT) and immunotherapy for the treatment of lung cancer. This book provides useful information to a range of audiences including clinical researchers working in the field of lung cancer, and undergraduate and postgraduate students from various disciplines such as pharmacy, microbiology, immunology, pharmacology, biotechnology, and health sciences.
Cancer --- Tumors --- Cancer Therapy. --- Tumour Immunology. --- Treatment. --- Immunological aspects. --- Lung Neoplasms --- Immunotherapy. --- therapy.
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Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
Cancer --- Chemokines --- Cytokines Therapeutic use. --- Chemotherapy. --- Therapeutic use. --- Cancer. --- Tumors --- Therapeutics. --- Cancers. --- Tumour Immunology. --- Immunological aspects. --- Neoplasms. --- Chemokines. --- Cytokines.
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Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
Tumors --- Cancer --- Oncology. --- Tumour Immunology. --- Cancer Therapy. --- Immunological aspects. --- Treatment. --- Cèl·lules T --- Anticossos monoclonals --- Oncologia --- Càncer --- Immunoteràpia
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Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
Cancer. --- Cancer --- Oncology. --- Immunotherapy. --- Tumors --- Nanomedicine. --- Cancer Biology. --- Cancer Therapy. --- Tumour Immunology. --- Cancer Nanotechnology. --- Treatment. --- Immunological aspects. --- Gastrointestinal Neoplasms. --- Tumor Microenvironment. --- Gastrointestinal system
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Cancer treatment is a challenging issue, while the treatment modalities have extended from traditional surgery, chemotherapy, and radiation therapy to new therapeutic approaches, including targeted therapy, immunotherapy, stem cell transplantation, and hormone therapy. Therefore, an interdisciplinary approach is needed to find a better therapeutic protocols in order to increase the prognosis and quality of life of patients with cancer. The second volume of the “Interdisciplinary Cancer Research” series, entitled “Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive volumes on different cancer treatment modalities and presents the most updated and peer-reviewed articles on cancer therapy. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers and clinicians who wish to extend their knowledge on cancer treatment.
Cancer --- Cancer. --- Tumors --- Stem cells. --- Oncology. --- Cancer Therapy. --- Cancer Biology. --- Tumour Immunology. --- Cancer Stem Cells. --- Treatment. --- Immunological aspects. --- Neoplasms --- Immunotherapy. --- Stem Cells. --- therapy.
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This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
Cancer. --- Tumors. --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Medicine—Research. --- Biology—Research. --- Tumors—Immunological aspects. --- Biomedical Research. --- Cancer Biology. --- Cancer Microenvironment. --- Tumour Immunology.
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Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
Cancer. --- Cancer --- Tumors --- Immunotherapy. --- Stem cells. --- Cancer Biology. --- Cancer Therapy. --- Tumour Immunology. --- Cancer Genetics and Genomics. --- Cancer Stem Cells. --- Treatment. --- Immunological aspects. --- Genetic aspects. --- Stem Cells. --- Digestive System Diseases. --- Carcinoma, Hepatocellular --- Liver Neoplasms --- Biliary Tract Neoplasms --- therapy. --- therapy --- Liver
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Tumors --- Neoplasms --- Immunotherapy. --- Immunological aspects --- therapy. --- Immunotherapies --- Tumours --- Immunological aspects. --- Pathology --- Cysts (Pathology) --- Oncology --- Tumor immunology --- Immunity, Active --- Immunologic Techniques --- Immunotherapy --- therapy --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- oncology --- immunology --- immunotherapy --- tumour immunology --- Combined Antibody Therapeutics
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Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Cancer research. --- Immunology. --- Cell biology. --- Internal medicine. --- Cancer Research. --- Cell Biology. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Cancer research --- Interleukins. --- Growth factors --- Lymphocytes --- Cancer. --- Tumors—Immunological aspects. --- Cytology. --- Cancer Microenvironment. --- Tumour Immunology. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors
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