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Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodelling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Cytology. --- Medicine. --- Oncology. --- Tumors -- Blood-vessels. --- Tumors --- Angiogenesis Modulating Agents --- Antineoplastic Agents --- Diseases --- Growth Inhibitors --- Blood Circulation --- Metaplasia --- Therapeutic Uses --- Growth Substances --- Pathologic Processes --- Cardiovascular Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Physiological Effects of Drugs --- Cardiovascular Physiological Phenomena --- Pharmacologic Actions --- Circulatory and Respiratory Physiological Phenomena --- Chemical Actions and Uses --- Phenomena and Processes --- Chemicals and Drugs --- Neoplasms --- Microcirculation --- Angiogenesis Inhibitors --- Neovascularization, Pathologic --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Microcirculation. --- Tumors. --- Tumours --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pathology --- Cysts (Pathology) --- Blood --- Circulation --- Oncology  . --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research

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To profoundly understand biology and harness its intricacies for human benefit and the mitigation of human harm requires cross-disciplinary approaches that incorporate sophisticated computational and mathematical modeling techniques. These integrative strategies are essential to achieve rapid and significant progress in issues, in health and disease, which span molecular, cellular and tissue levels. The use of mathematical models to describe various aspects of tumor growth has a very long history, dating back over six decades.  Recently, however, experimental and computational advances have improved our understanding of how processes act at multiple scales to mediate the development of tumor vasculature and drive the advancement of cancer. This book will showcase the development and utilization of new computational and mathematical approaches to address multiscale challenges associated with tumor vascular development.

Tumors. --- Tumors -- Blood-vessels. --- Tumors --- Diseases --- Neoplastic Processes --- Metaplasia --- Angiogenic Proteins --- Angiogenesis Modulating Agents --- Growth Inhibitors --- Antineoplastic Agents --- Models, Theoretical --- Investigative Techniques --- Pathologic Processes --- Intercellular Signaling Peptides and Proteins --- Therapeutic Uses --- Growth Substances --- Physiological Effects of Drugs --- Pharmacologic Actions --- Biological Factors --- Pathological Conditions, Signs and Symptoms --- Peptides --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Chemicals and Drugs --- Vascular Endothelial Growth Factors --- Angiogenesis Inhibitors --- Neoplasms --- Cell Transformation, Neoplastic --- Neovascularization, Pathologic --- Models, Biological --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Cancer cells. --- Blood-vessels. --- Cancer --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Cells --- Pathology, Cellular

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Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients.

Neoplasms --- Angiogenesis Inhibitors --- Neovascularization, Pathologic --- Neovascularization inhibitors --- Tumors --- Neovascularization --- Néovascularisation --- Tumeurs --- drug therapy. --- therapeutic use. --- blood supply. --- Blood-vessels --- Inhibiteurs --- Vaisseaux sanguins --- Cancer -- Treatment. --- Tumors -- Blood-vessels. --- Tumors. --- Angiogenesis Modulating Agents --- Antineoplastic Agents --- Growth Inhibitors --- Diseases --- Metaplasia --- Growth Substances --- Pathologic Processes --- Therapeutic Uses --- Pathological Conditions, Signs and Symptoms --- Physiological Effects of Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Oncology --- Medicine --- Health & Biological Sciences --- Antineoplastic agents. --- Neovascularization inhibitors. --- Neovascularization. --- Blood-vessels. --- Néovascularisation --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B --- Angiogenesis --- Cancer --- Angiogenesis inhibitors --- Tumor angiogenesis inhibitors --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Medicine. --- Cancer research. --- Molecular biology. --- Pharmacology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Molecular Medicine. --- Pharmacology/Toxicology. --- Antineoplastic agents --- Drugs --- Chemotherapy --- Growth --- Oncology  . --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Toxicology --- Health Workforce --- Drug effects --- Medical pharmacology --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Physiological effect