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Genes, tumor suppressor --- Tumor suppressor proteins --- Genes, tumor suppressor --- Tumor suppressor proteins

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Uveal Neoplasms --- Melanoma --- Gene Expression Profiling --- Biomarkers, Tumor --- Tumor Suppressor Proteins --- genetics --- pathology

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Antioncogenes. --- Tumor suppressor proteins. --- Antioncoproteins --- Growth suppressor proteins --- Metastasis suppressor proteins --- Proteins --- Antioncogenes --- Anti-oncogenes --- Cancer suppressor genes --- Emerogenes --- Tumor suppressing genes --- Tumor suppressor genes --- Cancer genes --- Tumor suppressor proteins

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Tumor suppressor genes (TSGs) and their signaling networks are fast growing areas in current biomedical science. These groups of genes, which are not limited to tumor suppression, play critical roles in many cellular activities. This book, "Future Aspects of Tumor Suppressor Genes", contains some fascinating fields, from basic to translational researches, in recent TSG studies. For example, several TSG signaling pathways are addressed in this book, and both mouse and Drosophila models used for the exploration of these genes are described based on the experimental evidence. A detailed review for current knowledge of microRNA studies in the regulation of tumor growth is introduced. Additionally, how natural compounds interfere with the progression of cancer development via TSG pathways is systemically summarized. Recent progresses in cell reprogramming and stemness transition processes regulated by TSG pathways are also included in this book.

Antioncogenes. --- Anti-oncogenes --- Cancer suppressor genes --- Emerogenes --- Tumor suppressing genes --- Tumor suppressor genes --- Cancer genes --- Tumor suppressor proteins --- Molecular biology

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With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of  25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications.

p53 antioncogene. --- p53 protein. --- Protein p53 --- Protein TP53 --- TP53 protein --- p53 gene --- p53 suppressor gene --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- DNA-binding proteins --- Phosphoproteins --- Tumor suppressor proteins --- Antioncogenes