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The aim of this work is to evaluate the sensitizer potential to antitumoral treatments of a new compound: S-nitrosocaptopril. This molecule possesses a NO moeity and an ACE inhibitor ability. Based on previous studies, we have hypothesized that S-nitrosocaptopril can increase the sensibilisation of tumor by increasing the 02 availability and decreasing the cellular respiration rate. We have investigated this effect by RPE spectryoscopy and MRI. We first evaluated the effect of tumor oxygenation by RPE L-band and have confirmed these results by 19F-MRI. The S-nitrosocaptopril has led to an increase of p02 after thirty minutes and the pression pressure was maintained during thirty more minutes. We have then searched the mechanism by investigating the tumor perfusion by patent blue staining. There was no difference between captopril and S­ nitrosocaptopril , perhaps because the captopril has elevated too much the blood flow to see any variation. After that, we have tested the ability of S-nitrosocaptopril to inhibit the oxygen consumption in vitro by EPR X-band spectrometer. There was a significant difference between the both treatments and the S-nitrosocaptopril consumes less oxygen than the captopril. We wanted to highlight the presence of NO by spin-trapping but this experiment failed. However, we have found that theS-nitrosocaptopril is superior to the captopril in their effect to increase the p02 in the tumor. It comes from decreasing the consumption of oxygen. The radio- and chemo sensitizer effect of S-nitrosocaptopril need still to be evaluated by assaying tumor regrowth delay assay.

Captopril --- S-nitrosocaptopril --- Tumor Microenvironment

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

tumor microenvironment --- monocyte --- macrophage --- neutrophil --- immunosuppression --- immunotherapy

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- tumor microenvironment --- monocyte --- macrophage --- neutrophil --- immunosuppression --- immunotherapy

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This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

Oncology. --- Pediatrics. --- Neurology. --- Neuroblastoma. --- Precision Medicine. --- Tumor Microenvironment.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- tumor microenvironment --- monocyte --- macrophage --- neutrophil --- immunosuppression --- immunotherapy