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RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2. For years vaccines have had an enormous impact on overcoming the global burden of diseases. Nowadays, a vast number of different approaches, from purified inactivated and live attenuated viruses, nucleic acid (DNA or RNA) based candidates, virus-like particles, subunit elements, and recombinant viruses are been employed to combat viruses. However, for many of them efficient vaccines are not yet available. This will probably change dramatically with the current Covid-19 pandemic, as a vast variety of vaccinology approaches are being tested against it, with hundreds of candidates under development, dozens of them already in clinical trials, a fact that is breaking records in vaccine development and implementation. This is becoming possible thanks to the enormous work carried out during years to have the bases for a quick response, even against unknown pathogens, in an impressive short time. Here, results obtained with different vaccine´s methodological approaches against human (HIV, HCV, HRV) animal (PRRSV, PEDV, FMDV, VHSV) and zoonotic (RVF, WNV), RNA viruses are presented by field experts.

Medicine --- artificial protein --- polyepitope B- and T-cell HIV-1 immunogen --- epitopes of broadly neutralizing HIV-1 antibodies --- peptide mimic of discontinuous epitope --- immunogenicity --- birds --- vaccines --- West Nile virus --- flavivirus --- herd immunity --- porcine epidemic diarrhea virus --- RNA interference --- processivity factor --- intestine epithelial cells --- N gene --- rotavirus nanoparticle vaccine --- gnotobiotic pigs --- FMDV --- peptide vaccine --- single dose --- amount --- pig --- VHSV --- non-virion (NV) --- transcriptome profiling --- rainbow trout --- immune pathways --- Rift Valley fever virus (RVFV) --- modified vaccinia Ankara (MVA) --- cellular response --- neutralizing antibodies --- Gn Gc glycoproteins --- passive serum:virus transfer --- hepatitis C virus --- neutralising antibodies --- animal models --- immune responses --- PRRSV Mosaic T-cell DNA vaccine VACV --- PRRS --- cross protection --- heterologous virus challenge --- artificial protein --- polyepitope B- and T-cell HIV-1 immunogen --- epitopes of broadly neutralizing HIV-1 antibodies --- peptide mimic of discontinuous epitope --- immunogenicity --- birds --- vaccines --- West Nile virus --- flavivirus --- herd immunity --- porcine epidemic diarrhea virus --- RNA interference --- processivity factor --- intestine epithelial cells --- N gene --- rotavirus nanoparticle vaccine --- gnotobiotic pigs --- FMDV --- peptide vaccine --- single dose --- amount --- pig --- VHSV --- non-virion (NV) --- transcriptome profiling --- rainbow trout --- immune pathways --- Rift Valley fever virus (RVFV) --- modified vaccinia Ankara (MVA) --- cellular response --- neutralizing antibodies --- Gn Gc glycoproteins --- passive serum:virus transfer --- hepatitis C virus --- neutralising antibodies --- animal models --- immune responses --- PRRSV Mosaic T-cell DNA vaccine VACV --- PRRS --- cross protection --- heterologous virus challenge

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"Computational Intelligence in Cancer Diagnosis: Progress and Challenges provides insights into the current strength and weaknesses of different applications and research findings on computational intelligence in cancer research. The book improves the exchange of ideas and coherence among various computational intelligence methods and enhances the relevance and exploitation of application areas for both experienced and novice end-users. Topics discussed include neural networks, fuzzy logic, connectionist systems, genetic algorithms, evolutionary computation, cellular automata, self-organizing systems, soft computing, fuzzy systems, and hybrid intelligent systems.The book's chapters are written by international experts from both cancer research, oncology and computational sides to cover different aspects and make it comprehensible for readers with no background on informatics. Key Features: Contains updated information about advanced computational intelligence, spanning the areas of neural networks, fuzzy logic, connectionist systems, genetic algorithms, evolutionary computation, cellular automata, self-organizing systems, soft computing, fuzzy systems, and hybrid intelligent systems in diagnosing cancer diseases. Discusses several cancer types, including their detection, treatment and prevention. Presents case studies that illustrate the applications of intelligent computing in data analysis to help readers to analyze and advance their research in cancer"--Provided by publisher.

Computational intelligence. --- Artificial Intelligence. --- Neoplasms --- Gene Expression Profiling. --- diagnosis. --- Intelligence, Computational --- Artificial intelligence --- Soft computing --- Gene Expression Monitoring --- Transcriptome Analysis --- Gene Expression Analysis --- Gene Expression Pattern Analysis --- Transcript Expression Analysis --- Transcriptome Profiling --- Transcriptomics --- mRNA Differential Display --- Analyses, Gene Expression --- Analyses, Transcript Expression --- Analyses, Transcriptome --- Analysis, Gene Expression --- Analysis, Transcript Expression --- Analysis, Transcriptome --- Differential Display, mRNA --- Differential Displays, mRNA --- Expression Analyses, Gene --- Expression Analysis, Gene --- Gene Expression Analyses --- Gene Expression Monitorings --- Gene Expression Profilings --- Monitoring, Gene Expression --- Monitorings, Gene Expression --- Profiling, Gene Expression --- Profiling, Transcriptome --- Profilings, Gene Expression --- Profilings, Transcriptome --- Transcript Expression Analyses --- Transcriptome Analyses --- Transcriptome Profilings --- mRNA Differential Displays --- Gene Expression --- Oligonucleotide Array Sequence Analysis --- Transcriptome --- Subtractive Hybridization Techniques --- Computational Intelligence --- AI (Artificial Intelligence) --- Computer Reasoning --- Computer Vision Systems --- Knowledge Acquisition (Computer) --- Knowledge Representation (Computer) --- Machine Intelligence --- Acquisition, Knowledge (Computer) --- Computer Vision System --- Intelligence, Artificial --- Intelligence, Machine --- Knowledge Representations (Computer) --- Reasoning, Computer --- Representation, Knowledge (Computer) --- System, Computer Vision --- Systems, Computer Vision --- Vision System, Computer --- Vision Systems, Computer --- Heuristics --- Cancer --- Artificial Intelligence --- Diagnosis --- Data processing. --- diagnosis

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Presenting an area of research that intersects with and integrates diverse disciplines, including genomics, epigenetics, proteomics, and cellular biology, among others, Formalin-Fixed Paraffin-Embedded Tissues: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Compiled in order to provide researchers with up-to-date methodological information pertaining to the utilization of genomic, transcriptomic, and proteomic data in diagnosis, prognosis, and tailored therapy, the ultimate aim of this volume is to decipher diseases at a molecular level. Divided into multiple convenient chapters, this detailed book covers various techniques to construct and utilize tissue arrays, it also provides detailed protocols in immunohistochemistry, immunofluorescence, fluorescent and chromogenic in situ hybridization, and ultimately introduces protocols for FFPET microdissection and nucleic acids extraction for their utilization in advanced techniques such as microarray CGH, DNA methylation and pyrosequencing. The volume also discusses FFPET research from an ethical standpoint and concludes with a chapter on novel tissue fixative. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Formalin-Fixed Paraffin-Embedded Tissues: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this vital field of research.

Human histology. Human cytology --- Chemical laboratory practice --- Tissues --- Tissue culture --- Diagnostic immunohistochemistry --- Tissue Embedding --- Genetic Techniques --- Microarray Analysis --- Culture Techniques --- Publication Formats --- Investigative Techniques --- Clinical Laboratory Techniques --- Histocytological Preparation Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Publication Characteristics --- Microchip Analytical Procedures --- Cytological Techniques --- Chemistry Techniques, Analytical --- Histological Techniques --- Gene Expression Profiling --- Laboratory Manuals --- Paraffin Embedding --- Tissue Array Analysis --- Methods --- Tissue Culture Techniques --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Physiology --- Biophysics --- Analysis --- Embedding, Paraffin --- Gene Expression Monitoring --- Transcriptome Analysis --- Gene Expression Pattern Analysis --- Transcript Expression Analysis --- Transcriptome Profiling --- mRNA Differential Display --- Analyses, Transcript Expression --- Analyses, Transcriptome --- Analysis, Transcript Expression --- Analysis, Transcriptome --- Differential Display, mRNA --- Differential Displays, mRNA --- Display, mRNA Differential --- Displays, mRNA Differential --- Gene Expression Monitorings --- Gene Expression Profilings --- Monitoring, Gene Expression --- Monitorings, Gene Expression --- Profiling, Gene Expression --- Profiling, Transcriptome --- Profilings, Gene Expression --- Profilings, Transcriptome --- Transcript Expression Analyses --- Transcriptome Analyses --- Transcriptome Profilings --- mRNA Differential Displays --- Histologic Technic --- Histologic Technics --- Histologic Technique --- Histologic Techniques --- Histological Technics --- Technic, Histologic --- Technics, Histologic --- Technique, Histologic --- Techniques, Histologic --- Histological Technic --- Histological Technique --- Technic, Histological --- Technics, Histological --- Technique, Histological --- Techniques, Histological --- Histology --- Analytical Chemistry Methods --- Analytical Chemistry Techniques --- Analytical Chemistry Method --- Analytical Chemistry Technique --- Chemistry Method, Analytical --- Chemistry Methods, Analytical --- Chemistry Technique, Analytical --- Method, Analytical Chemistry --- Methods, Analytical Chemistry --- Technique, Analytical Chemistry --- Techniques, Analytical Chemistry --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- Microchip Analysis --- Analyses, Microchip --- Analysis, Microchip --- Analytical Procedure, Microchip --- Analytical Procedures, Microchip --- Microchip Analytical Procedure --- Procedure, Microchip Analytical --- Procedures, Microchip Analytical --- Cytohistologic Preparation Technics --- Cytohistologic Preparation Technique --- Cytohistologic Preparation Techniques --- Cytohistological Preparation Technic --- Cytohistological Preparation Technics --- Cytohistological Preparation Technique --- Histocytologic Preparation Technic --- Histocytologic Preparation Technics --- Histocytologic Preparation Technique --- Histocytologic Preparation Techniques --- Histocytological Preparation Technic --- Histocytological Preparation Technics --- Histocytological Preparation Technique --- Preparation Technic, Cytohistologic --- Preparation Technic, Cytohistological --- Preparation Technic, Histocytologic --- Preparation Technic, Histocytological --- Preparation Technics, Cytohistologic --- Preparation Technics, Cytohistological --- Preparation Technics, Histocytologic --- Preparation Technics, Histocytological --- Preparation Technique, Cytohistologic --- Preparation Technique, Cytohistological --- Preparation Technique, Histocytologic --- Preparation Technique, Histocytological --- Preparation Techniques, Cytohistologic --- Preparation Techniques, Cytohistological --- Preparation Techniques, Histocytologic --- Preparation Techniques, Histocytological --- Technic, Cytohistologic Preparation --- Technic, Cytohistological Preparation --- Technic, Histocytologic Preparation --- Technic, Histocytological Preparation --- Technics, Cytohistologic Preparation --- Technics, Cytohistological Preparation --- Technics, Histocytologic Preparation --- Technics, Histocytological Preparation --- Technique, Cytohistologic Preparation --- Technique, Cytohistological Preparation --- Technique, Histocytologic Preparation --- Technique, Histocytological Preparation --- Techniques, Cytohistologic Preparation --- Techniques, Cytohistological Preparation --- Techniques, Histocytologic Preparation --- Techniques, Histocytological Preparation --- Cytohistological Preparation Techniques --- Cytohistologic Preparation Technic --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Diagnoses, Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Technique, Clinical Laboratory --- Techniques, Clinical Laboratory --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Culture Technique --- Technique, Culture --- Techniques, Culture --- Microarray Analytical Devices --- Microarray Microchips --- Nanoarray Analytical Devices --- Analysis, Microarray --- Analytical Device, Microarray --- Analytical Device, Nanoarray --- Analytical Devices, Microarray --- Analytical Devices, Nanoarray --- Device, Microarray Analytical --- Device, Nanoarray Analytical --- Devices, Microarray Analytical --- Devices, Nanoarray Analytical --- Microarray Analytical Device --- Microarray Microchip --- Microchip, Microarray --- Microchips, Microarray --- Nanoarray Analytical Device --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Diagnostic immunohistology --- Culture Technique, Tissue --- Culture Techniques, Tissue --- Tissue Culture Technique --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- methods --- Cultures and culture media --- Cell Array Analysis --- Cell Microarray Analysis --- Tissue Microarray Analysis --- Analyses, Cell Array --- Analyses, Cell Microarray --- Analyses, Tissue Array --- Analyses, Tissue Microarray --- Analysis, Cell Array --- Analysis, Cell Microarray --- Analysis, Tissue Array --- Analysis, Tissue Microarray --- Array Analyses, Cell --- Array Analyses, Tissue --- Array Analysis, Cell --- Array Analysis, Tissue --- Cell Array Analyses --- Cell Microarray Analyses --- Microarray Analyses, Cell --- Microarray Analyses, Tissue --- Microarray Analysis, Cell --- Microarray Analysis, Tissue --- Tissue Array Analyses --- Tissue Microarray Analyses --- Embedding, Tissue --- Medicine. --- Pathology. --- Molecular Medicine. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Health Workforce

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Gene Expression Profiling --- Nervous System Diseases --- Oligonucleotide Array Sequence Analysis --- Nervous System Physiological Phenomena --- Microarray Analysis --- Sequence Analysis --- Molecular Probe Techniques --- Genetic Techniques --- Nucleic Acid Hybridization --- Musculoskeletal and Neural Physiological Phenomena --- Diseases --- Microchip Analytical Procedures --- Investigative Techniques --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry Techniques, Analytical --- Analytical Chemistry Methods --- Analytical Chemistry Techniques --- Analytical Chemistry Method --- Analytical Chemistry Technique --- Chemistry Method, Analytical --- Chemistry Methods, Analytical --- Chemistry Technique, Analytical --- Method, Analytical Chemistry --- Methods, Analytical Chemistry --- Technique, Analytical Chemistry --- Techniques, Analytical Chemistry --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Microchip Analysis --- Analyses, Microchip --- Analysis, Microchip --- Analytical Procedure, Microchip --- Analytical Procedures, Microchip --- Microchip Analytical Procedure --- Procedure, Microchip Analytical --- Procedures, Microchip Analytical --- Micromanipulation --- Nanotechnology --- Lab-On-A-Chip Devices --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Genomic Hybridization --- Acid Hybridization, Nucleic --- Acid Hybridizations, Nucleic --- Genomic Hybridizations --- Hybridization, Genomic --- Hybridization, Nucleic Acid --- Hybridizations, Genomic --- Hybridizations, Nucleic Acid --- Nucleic Acid Hybridizations --- DNA --- Nucleic Acid Probes --- Oligonucleotide Probes --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Genetic Counseling --- Genetic Phenomena --- Molecular Probe Technic --- Molecular Probe Technics --- Molecular Probe Technique --- Technic, Molecular Probe --- Technics, Molecular Probe --- Technique, Molecular Probe --- Techniques, Molecular Probe --- Probe Technic, Molecular --- Probe Technics, Molecular --- Probe Technique, Molecular --- Probe Techniques, Molecular --- Analysis, Sequence --- Determination, Sequence --- Determinations, Sequence --- Sequence Determinations --- Sequence Determination --- Analyses, Sequence --- Sequence Analyses --- Microarray Analytical Devices --- Microarray Microchips --- Nanoarray Analytical Devices --- Analysis, Microarray --- Analytical Device, Microarray --- Analytical Device, Nanoarray --- Analytical Devices, Microarray --- Analytical Devices, Nanoarray --- Device, Microarray Analytical --- Device, Nanoarray Analytical --- Devices, Microarray Analytical --- Devices, Nanoarray Analytical --- Microarray Analytical Device --- Microarray Microchip --- Microchip, Microarray --- Microchips, Microarray --- Nanoarray Analytical Device --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiological Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- DNA Arrays --- DNA Chips --- DNA Microchips --- Gene Chips --- Oligodeoxyribonucleotide Array Sequence Analysis --- Oligonucleotide Microarrays --- Sequence Analysis, Oligonucleotide Array --- cDNA Arrays --- DNA Microarrays --- Oligonucleotide Arrays --- cDNA Microarrays --- Array, DNA --- Array, Oligonucleotide --- Array, cDNA --- Arrays, DNA --- Arrays, Oligonucleotide --- Arrays, cDNA --- Chip, DNA --- Chip, Gene --- Chips, DNA --- Chips, Gene --- DNA Array --- DNA Chip --- DNA Microarray --- DNA Microchip --- Gene Chip --- Microarray, DNA --- Microarray, Oligonucleotide --- Microarray, cDNA --- Microarrays, DNA --- Microarrays, Oligonucleotide --- Microarrays, cDNA --- Microchip, DNA --- Microchips, DNA --- Oligonucleotide Array --- Oligonucleotide Microarray --- cDNA Array --- cDNA Microarray --- Combinatorial Chemistry Techniques --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Gene Expression Monitoring --- Transcriptome Analysis --- Gene Expression Pattern Analysis --- Transcript Expression Analysis --- Transcriptome Profiling --- mRNA Differential Display --- Analyses, Transcript Expression --- Analyses, Transcriptome --- Analysis, Transcript Expression --- Analysis, Transcriptome --- Differential Display, mRNA --- Differential Displays, mRNA --- Display, mRNA Differential --- Displays, mRNA Differential --- Gene Expression Monitorings --- Gene Expression Profilings --- Monitoring, Gene Expression --- Monitorings, Gene Expression --- Profiling, Gene Expression --- Profiling, Transcriptome --- Profilings, Gene Expression --- Profilings, Transcriptome --- Transcript Expression Analyses --- Transcriptome Analyses --- Transcriptome Profilings --- mRNA Differential Displays --- Gene Expression --- Transcriptome --- Subtractive Hybridization Techniques --- methods --- physiology --- Gene Expression Microarray Analysis --- Gene Expression Analysis --- Transcriptomics --- Analyses, Gene Expression --- Analysis, Gene Expression --- Expression Analyses, Gene --- Expression Analysis, Gene --- Gene Expression Analyses