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Toxicology --- Toxins --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Natural toxicants --- Toxicants, Natural --- Toxins and antitoxins --- Pharmacogenetics --- Antigens --- Metabolites --- Poisons --- Antitoxins --- Detoxification (Health) --- Toxicology. --- Toxins, Biological. --- Biological Toxins --- Toxoids

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Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at the individual and at the population level. The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness. The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. Topics include household studies, evaluating correlates of immune protection, and applications of casual inference. Material on concepts of infectious disease epidemiology, transmission models, casual inference, and vaccines provides background for the reader. This is the first book to present vaccine evaluation in this comprehensive conceptual framework. This book is intended for colleagues and students in statistics, biostatistics, epidemiology, and infectious diseases. Most essential concepts are described in simple language accessible to epidemiologists, followed by technical material accessible to statisticians. M. Elizabeth Halloran and Ira Longini are professors of biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Claudio Struchiner is professor of epidemiology and biostatistics at the Brazilian School of Public Health of the Oswaldo Cruz Foundation in Rio de Janeiro. The authors are prominent researchers in the area. Halloran and Struchiner developed the study designs for dependent happenings to delineate indirect, total, and overall effects. Halloran has made contributions at the interface of epidemiological methods, causal inference, and transmission dynamics. Longini works in the area of stochastic processes applied to epidemiological infectious disease problems, specializing in the mathematical and statistical theory of epidemics. Struchiner has contributed to understanding the role of transmission in interpreting vaccine effects.

Mathematical statistics --- vaccinatie --- Vaccines --- Epidemiology --- Case-control method --- Epidémiologie --- Research --- Statistical methods --- Recherche --- EPUB-LIV-FT LIVMATHE LIVSTATI SPRINGER-B --- Vaccines - Research --- Vaccines - Statistical methods --- Epidemiology - Research --- statistics and numerical data [Subheading] --- QW 805 Vaccines. Antitoxins. Toxoids --- Epidemiologic Study Characteristics as Topic --- Health care evaluation mechanisms --- Models, statistical --- Research design --- Vaccinations, protocols

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Physiology, Comparative --- Biochemistry --- Pharmacology --- Toxicology --- Pharmaceutical Preparations. --- Poisons. --- Toxicology. --- Pharmacologie --- Toxicologie --- Biochemistry. --- Pharmacology. --- Physiology, Comparative. --- Farmacologie. --- Toxicologie. --- Toxins, Biological. --- Biological Toxins --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Drugs --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Chemicals --- Comparative physiology --- Drug effects --- Medical pharmacology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Composition --- Toxoids --- Drug Dosage Calculations --- Medicine --- Poisoning --- Poisons --- Medicine, Comparative --- Zoology --- Medical sciences --- Chemotherapy --- Pharmacy --- Biology --- Chemistry --- Physiological effect --- Pharmaceuticals --- Poison --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical

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toxicology --- natural toxins --- poisoning --- venom --- antivenom --- Toxins --- Venom --- Venom. --- Toxins. --- Toxicology. --- Toxins, Biological. --- Biological Toxins --- Toxoids --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics --- Natural toxicants --- Toxicants, Natural --- Antigens --- Metabolites --- Poisons --- Antitoxins --- Detoxification (Health) --- Venoms --- Antivenins --- Poisonous animals --- Toxins and antitoxins

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Since the antibiotic inefficiency crisis leads to clinical and economical disabilities, one of the major challenges of scientists is to develop novel methods to handle infections. This book offers a perspective on alternate antimicrobial approaches based on naturally-derived products in order to modulate the virulence of pathogens and more

Anti-Bacterial Agents --- Virulence Factors --- Nanotechnology --- Bacterial Infections --- Natural Science Disciplines --- Toxins, Biological --- Anti-Infective Agents --- Bacterial Infections and Mycoses --- Miniaturization --- Technology --- Diseases --- Disciplines and Occupations --- Biological Factors --- Therapeutic Uses --- Chemicals and Drugs --- Technology, Industry, and Agriculture --- Pharmacologic Actions --- Chemical Actions and Uses --- Technology, Industry, Agriculture --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biological Agents --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Arts, Industrial --- Industrial Arts --- Miniaturisation --- Miniaturisations --- Miniaturizations --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Biological Toxins --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Bacterial Infection --- Infection, Bacterial --- Infections, Bacterial --- Nanotechnologies --- Pathogenicity Factors --- Factors, Pathogenicity --- Factors, Virulence --- Anti-Bacterial Compounds --- Anti-Mycobacterial Agents --- Antibacterial Agents --- Antibiotic --- Antimycobacterial Agents --- Bacteriocidal Agents --- Bacteriocides --- Antibiotics --- Agents, Anti-Bacterial --- Agents, Anti-Mycobacterial --- Agents, Antibacterial --- Agents, Antimycobacterial --- Agents, Bacteriocidal --- Anti Bacterial Agents --- Anti Bacterial Compounds --- Anti Mycobacterial Agents --- Compounds, Anti-Bacterial --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Biological Products --- Cloud Computing --- Microchemistry --- Infection --- Parasites --- Toxoids --- Nanotubes --- Microchip Analytical Procedures --- Nanostructures --- Virulence --- Infections --- Anti-infective agents. --- Biotechnology. --- Microbiology. --- Infectious and parasitic diseases. --- Microbial biology --- Biology --- Microorganisms --- Molecular technology --- Nanoscale technology --- High technology --- Chemical engineering --- Genetic engineering --- Antiinfective agents --- Antimicrobial agents --- Antimicrobial drugs --- Antimicrobials --- Drugs --- antimicrobial therapy, molecular modulation, virulence, drug delivery nanoshuttles.