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La problématique du tabac est importante en Belgique. Différents traitements médicamenteux sont sur le marché, mais leur efficacité est loin d’être optimale. La pharmacogénétique aurait un potentiel impact clinique. Des centaines de gènes sont impliqués dans la dépendance au tabac, mais aussi dans la pharmacocinétique et la pharmacodynamique des traitements. De plus en plus, d’études sont réalisées sur ces gènes. Ce mémoire a pour but d’évaluer l’influence du génotype du fumeur dans sa prise en charge. Tobacco smoking remains a major health problem in Belgium. Different drug treatments are available but their efficacy is not optimal, opening perspectives for a new pharmacogenetics approach. A hundred of genes are implicated in the tobacco dependence and in the pharmacokinetics and pharmacodynamics of treatments. These genes are the subject of a growing number of studies. This thesis aims to evaluate the influence of a smoker’s genotype on the treatments.

Genotype --- Tobacco Use Disorder --- Nicotine --- Tobacco Use Cessation Devices

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