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Tissue Therapy, Historical

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Cardiac cell repair therapy is an innovative approach for the treatment of heart failure, a severe pathology in which the heart becomes unable to perform its vital functions. Stem cells taken from the patient are injected into the injured myocardium after differentiation in vitro into pre-cardiac stem cells. A high number of studies evaluated the ideal cell type, the feasibility and the safety of stem cell therapy. However, the results are still modest showing a slight improvement in heart function. These results are however promising and further studies are necessary to go deeper into several critical parameters like the delivery system or the administration timing Depuis quelques années, la thérapie cellulaire cardiaque apparaît comme une approche innovante dans le traitement de l’insuffisance cardiaque, une pathologie grave dans laquelle le cœur devient incapable d’assurer ses fonctions vitales. Cette thérapie, qui a pour objectif d’améliorer la fonction cardiaque, est basée sur les capacités des cellules souches mésenchymateuses, prélevées à partir de la moelle osseuse du patient, à se différencier en cardiomyocytes après réimplantation dans l’environnement myocardique natif. Les études préalablement réalisées ont permis de déterminer le type cellulaire idéal, la faisabilité et la sécurité des thérapies cellulaires. Cependant, les résultats parfois encore mitigés, ne montrent qu’une faible mais non négligeable amélioration de la fonction ventriculaire gauche. Ces résultats sont très prometteurs car il n’existe, à ce jour, aucune autre thérapie curative de l’insuffisance cardiaque. D’autre part, de nombreuses études sont encore nécessaires afin d’approfondir plusieurs paramètres cruciaux comme, par exemple, la méthode d’injection ou encore le timing d’administration

Tissue Therapy --- Heart Failure --- Myocardium

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Cell Biology --- Tissue Therapy, Historical

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Tissue Therapy --- Hematopoietic Stem Cell Transplantation --- Hematopoietic Stem Cells --- Health Sciences --- General and Others --- Hematology

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Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells.   However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.  This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of  mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.   .

Adult stem cells -- Cytology. --- Biology. --- Stem cells. --- Mesenchymal stem cells --- Stem Cell Transplantation --- Cell Transplantation --- Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Mesenchymal Stem Cell Transplantation --- Biology --- Health & Biological Sciences --- Cytology --- Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Life sciences. --- Biotechnology. --- Cell biology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Multipotent stem cells --- Cytology. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Mesenchymal Stem Cells --- Cell- and Tissue-Based Therapy. --- Mesenchymal Stem Cell Transplantation. --- physiology. --- Transplantation, Mesenchymal Stem Cell --- Stem Cell Transplantation, Mesenchymal --- Therapy, Cell --- Therapy, Tissue --- Cell Therapy --- Tissue Therapy --- Cell and Tissue Based Therapy --- Tissue Therapy, Historical --- transplantation