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This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis.

Thrombolytic therapy. --- Fibrinolytic therapy --- Thrombolysis --- Thrombosis --- Chemotherapy --- Fibrinolysis --- Haematology

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Brain --- Blood flow --- Cerebrovascular Circulation. --- Thrombolytic Therapy. --- Mechanical Thrombolysis. --- Blood flow. --- Blood-vessels --- Blood-vessels. --- Therapeutic Thrombolysis --- Therapy, Fibrinolytic --- Therapy, Thrombolytic --- Fibrinolytic Therapy --- Thrombolysis, Therapeutic --- Fibrinolytic Therapies --- Therapeutic Thrombolyses --- Therapies, Fibrinolytic --- Therapies, Thrombolytic --- Thrombolyses, Therapeutic --- Thrombolytic Therapies --- Cerebral Blood Flow --- Cerebral Circulation --- Cerebral Perfusion Pressure --- Circulation, Cerebrovascular --- Blood Flow, Cerebral --- Blood Flows, Cerebral --- Cerebral Blood Flows --- Cerebral Circulations --- Cerebral Perfusion Pressures --- Circulation, Cerebral --- Circulations, Cerebral --- Flow, Cerebral Blood --- Flows, Cerebral Blood --- Perfusion Pressure, Cerebral --- Perfusion Pressures, Cerebral --- Pressure, Cerebral Perfusion --- Pressures, Cerebral Perfusion --- Blood --- Cerebrum --- Mind --- Flow --- Mechanical Clot Disruption --- Clot Disruption, Mechanical --- Clot Disruptions, Mechanical --- Disruption, Mechanical Clot --- Disruptions, Mechanical Clot --- Mechanical Clot Disruptions --- Thrombolysis, Mechanical --- neuroimaging --- rehabilitation therapy --- neurology --- neurosurgery --- neuroscience --- thrombolysis --- Cerebral circulation --- Body fluid flow --- Hemodynamics --- Thrombolytic Therapy --- Thrombectomy --- Mechanical Thrombolysis --- Central nervous system --- Head --- Circulation --- Physiology --- Brain Blood Flow --- Regional Cerebral Blood Flow --- Blood Flow, Brain --- Brain Blood Flows --- Flow, Brain Blood

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Thrombotic disorders of the circulatory system represent the leading cause of morbidity, mortality, and health care expenditure in the United States. The Second Edition of Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the managment of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on management guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders.

Thrombolytic therapy. --- Fibrinolytic agents. --- Thrombosis --- Blood --- Cardiovascular system --- Protein C deficiency --- Protein S deficiency --- Antithrombotic agents --- Antithrombotics --- Fibrinolytic enzymes --- Fibrinolytics --- Thrombolytic agents --- Thrombolytics --- Enzymes --- Hematologic agents --- Fibrinolytic therapy --- Thrombolysis --- Chemotherapy --- Fibrinolysis --- Treatment. --- Coagulation --- Diseases

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Plasminogen Activator, Tissue-Type --- Thrombosis --- Thrombolytic therapy. --- Tissue plasminogen activator --- Thrombolyse --- therapeutic use. --- drug therapy. --- Therapeutic use. --- Tissue Plasminogen Activator --- Thrombolytic therapy --- -Activator, Tissue plasminogen --- Plasminogen activator, Tissue-type --- Tissue-type plasminogen activator --- TPA (Biochemistry) --- Circulating anticoagulants --- Endothelium --- Plasminogen activators --- Fibrinolytic therapy --- Thrombolysis --- Chemotherapy --- Fibrinolysis --- Therapeutic use --- -therapeutic use. --- Activator, Tissue plasminogen --- drug therapy --- therapeutic use

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Fibrinolysis --- Thrombosis --- Thrombolytic therapy --- Thrombose --- Thrombolyse --- Fibrinolyse --- Periodicals --- Périodiques --- Thrombosis. --- Fibrinolysis. --- Vascular Diseases. --- Thrombolytic therapy. --- Fibrinolyses --- Fibrin Clot Lysis Time --- Thrombus --- Thromboses --- Thrombotic Microangiopathies --- Health Sciences --- Cardiology --- Clinical Medicine --- Diabetes and Hypertension --- Hematology --- Pathology --- Blood Clot --- Blood Clots --- Clot, Blood --- Clots, Blood --- Blood Coagulation --- Ischemic Stroke --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Blood --- Cardiovascular system --- Protein C deficiency --- Protein S deficiency --- Fibrinolytic therapy --- Thrombolysis --- Chemotherapy --- Coagulation --- Diseases