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Platelet function, or clot formation, is difficult to assess, but extremely important because inadvertent or excessive platelet activation underlies many common cardiovascular disorders, such as myocardial infarction, unstable angina, and stroke. In Platelet Function: Assessment, Diagnosis, and Treatment, a panel of leading researchers and clinicians review the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed. Comprehensive and state of the art, Platelet Function: Assessment, Diagnosis, and Treatment offers vascular researchers and clinicians a sound foundation for understanding platelet biology, assessing thrombotic risk in patients, and determining the rational dosing of antiplatelet agents.

Blood platelet disorders --- Blood platelets --- Diagnosis. --- Examination. --- Thrombocytopathy --- Blood --- Diseases --- Cardiology. --- Heart --- Internal medicine

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Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function. Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource.

Blood platelets. --- Blood Platelets. --- Blood Platelet Disorders. --- Thrombocytopathy --- Blood Platelet Disorder --- Disorder, Blood Platelet --- Disorders, Blood Platelet --- Platelet Disorder, Blood --- Platelet Disorders, Blood --- Thrombocytopathies --- Platelets --- Thrombocytes --- Blood Platelet --- Platelet --- Platelet, Blood --- Platelets, Blood --- Thrombocyte --- Blood cells --- Megakaryocytes

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Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.

Blood platelet disorders. --- Blood platelets --- Blood platelet receptors --- Platelet membrane receptors --- Platelet receptors --- Cell receptors --- Thrombocytopathy --- Blood --- Adhesiveness, Blood platelet --- Aggregation, Blood platelet --- Blood platelet aggregation --- Platelet adhesiveness --- Platelet aggregation --- Cell aggregation --- Receptors. --- Aggregation. --- Diseases --- Blood platelet disorders --- Blood Platelet Disorders --- Blood Platelets --- Platelet Aggregation Inhibitors --- Aggregation --- Receptors --- physiopathology --- drug effects --- pathology --- physiology --- therapeutic use

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PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Blood platelet disorders. --- Blood platelets. --- Blood platelets --- Blood platelet disorders --- Blood Platelets --- Blood Platelet Disorders --- Hematologic Diseases --- Blood Cells --- Cells --- Hemic and Lymphatic Diseases --- Blood --- Hemic and Immune Systems --- Anatomy --- Diseases --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Anatomies --- Hemic System --- System, Hemic --- Water --- Cell --- Blood Corpuscles --- Blood Cell --- Blood Corpuscle --- Cell, Blood --- Cells, Blood --- Corpuscle, Blood --- Corpuscles, Blood --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Thrombocytopathy --- Blood Platelet Disorder --- Disorder, Blood Platelet --- Disorders, Blood Platelet --- Platelet Disorder, Blood --- Platelet Disorders, Blood --- Thrombocytopathies --- Platelets --- Thrombocytes --- Blood Platelet --- Platelet --- Platelet, Blood --- Platelets, Blood --- Thrombocyte --- blood --- cytology --- Cell Biology --- Hematology --- Blood cells --- Megakaryocytes --- Blood Platlets. --- Blood Platelet Disorders.