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gentherapie --- celtherapie --- Frankrijk --- thérapie génique --- thérapie cellulaire --- France
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De nombreuses thérapies peuvent être utilisées pour le traitement symptomatique de l’ostéoarthrose. Cependant, un intérêt majeur émerge pour la recherche d’un traitement afin de ralentir, voire même de lutter contre cette pathologie dégénérative ostéoarticulaire. Dans cette optique, les thérapies régénératives et plus particulièrement l’utilisation de cellules souches mésenchymateuses pourraient être une solution innovante dans le traitement de l’ostéoarthrose. L’utilisation de cellules souches autologues présente un désavantage majeur qu’est le délai entre le prélèvement chez le patient et l’application thérapeutique possible. La thérapie cellulaire allogénique permettrait de lutter contre cette limite avec une disponibilité immédiate. Une question majeure émerge sur la sécurité et l’efficacité des cellules souches allogéniques comparées aux cellules autologues, d’où l’intérêt de ce travail. L’allogreffe semble être sûre et efficace, ce qui en plus du bénéfice lié à son utilisation, en ferait la thérapie idéale contre l’ostéoarthrose chez le cheval. Malgré tout, de nombreuses interrogations doivent trouver leurs réponses avant de pouvoir utiliser convenablement et de manière optimale les cellules souches mésenchymateuses allogéniques comme traitement régénératif de l’ostéoarthrose équine.
cellules souches mésenchymateuses --- autologues et allogéniques --- comparaison --- ostéoarthrose équine --- cheval --- ostéoarthrose --- thérapie cellulaire --- traitement --- Sciences du vivant > Médecine vétérinaire & santé animale
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Cell therapy --- Cell transplantation --- Cells--Therapeutic use --- Cells--Transplantation --- Cellulaire therapie --- Cellulaire transplantatie --- Cellular therapy --- Cellular transplantation --- Cellules--Transplantation --- Celtherapie --- Celtransplantatie --- Therapie [Cellulaire ] --- Therapy [Cellular ] --- Thérapie cellulaire --- Transplantatie [Cel] --- Transplantation cellulaire --- Cloning --- Fetus --- Clonage --- Foetus --- Research --- Therapeutic use --- Recherche --- Emploi en thérapeutique --- therapeutisch kloneren (therapeutisch klonen) --- clonage thérapeutique (clonage humain thérapeutique) --- Thérapie cellulaire --- Emploi en thérapeutique --- Cellules souches embryonnaires --- Transplantation --- Clone cells
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Cell Transplantation --- Cytokines --- Cellular therapy --- Cell transplantation --- Thérapie cellulaire --- Cellules --- Therapeutic use --- Periodicals --- Periodicals. --- Emploi en thérapeutique --- Périodiques --- Greffe --- Health Sciences --- Life Sciences --- Genetics --- Immunology --- Pharmacy and Pharmacology --- Therapeutics --- General and Others --- Thérapie cellulaire --- Emploi en thérapeutique --- Périodiques --- EBSCOASP-E ELSEVIER-E EPUB-ALPHA-C EPUB-PER-FT MDCYTOLO MDTREATM
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Philosophes, journalistes, politiques, théologiens, juristes, médecins, biologistes, psychanalystes, tous parlent de l'embryon... Mais qu'est-ce vraiment que l'embryon ? Rassemblant plus de 70 scientifiques de renommée internationale, spécialistes de la biologie du développement, des biotechnologies humaines et animales, de la physiologie et de l'immunologie de la grossesse, de la génétique et de la médecine de la reproduction, cet ouvrage présente une synthèse des connaissances actuelles sur l'embryon humain et animal. Les thèmes abordés - clonage embryonnaire et somatique, transgenèse, thérapie cellulaire, diagnostic génétique pré-implantatoire, développement et évolution, génétique et épigénétique... - donneront aux lecteurs, dans un langage accessible à tous, des éléments de réponse aux questions que font naître la biologie et la médecine d'aujourd'hui.
Animal --- animals --- men --- Transfert embryonnaire --- Embryo transfer --- Reproduction sexuée --- Sexual reproduction --- Fertilité --- Fertility --- Trouble de la reproduction --- Reproductive disorders --- Génie génétique --- genetic engineering --- Hérédité --- genetic inheritance --- Maladie de l'homme --- Human diseases --- Thérapeutique --- therapy --- Développement embryonnaire --- Embryonic development --- Immunologie --- Immunology --- Activité enzymatique --- Enzyme activity --- Hormone --- Hormones --- Clonage --- cloning --- Ethics --- embryo --- ontwikkelingsbiologie --- embryonale stamcel (menselijke embryonale stamcel, totipotent, pluripotent) --- kloneren (klonen, therapeutisch kloneren) --- celtherapie --- zwangerschap --- fysiologie (fysiologische benadering) --- in-vitrofertilisatie (bevruchting in vitro, proefbuisbaby's) --- pre-implantatie genetische diagnose (PGD) --- embryon --- biologie du développement --- cellule souche embryonnaire (cellule souche embryonnaire humaine) --- clonage (clonage thérapeutique) --- thérapie cellulaire --- grossesse --- physiologie (approche physiologique --- fécondation in vitro (fertilisation in vitro, FIV, fécondation in vitro et embryo transfert, FIVETE) --- diagnostique génétique pré-implantatoire (DPI, diagnostic préimplantatoire) --- Enbryon animal --- Therapie cellulaire
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Molecular genetics --- Cellular therapy --- Génétique moléculaire --- Thérapie cellulaire --- Periodicals. --- Periodicals --- Périodiques --- Biochemical Phenomena. --- Biological Therapy. --- Molecular genetics. --- Biologic Therapy --- Biotherapy --- Therapy, Biological --- Biologic Therapies --- Biological Therapies --- Biotherapies --- Therapies, Biologic --- Therapies, Biological --- Therapy, Biologic --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Processes --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- molecular therapy --- gene therapy --- cell-based therapy --- technology development --- drug development --- Genetics --- Molecular biology --- Molecular Biology
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Medical genetics --- Genes --- Génétique médicale --- Gènes --- Periodicals. --- Périodiques --- Genetic transformation --- Gene therapy --- Cellular therapy --- Gene Transfer. --- Genetic Therapy. --- Thérapie génique --- Thérapie cellulaire --- Cellular therapy. --- Gene therapy. --- Genetic transformation. --- Gene Transfer Techniques. --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Genetic Therapy --- Transgenes --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Gene --- Therapy, Somatic Gene --- Gene Therapy --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Periodicals --- Chemistry --- Toxicology
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Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features * Comprehensive review by leading researchers * Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules * Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy * Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues.
Hematopoietic Stem Cell Transplantation. --- Gene therapy. --- Immunotherapy. --- Cellular therapy. --- Hematopoietic stem cells --- Thérapie cellulaire --- Cellules souches hématopoïétiques --- Transplantation. --- Transplantation --- Stem Cell Transplantation --- Hematopoietic Stem Cell Transplantation --- Cell Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- General Surgery --- Transplantations --- Transplantation Immunology --- Transplantation Conditioning --- Transplantation, Cell --- Cells --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- Transplantation, Stem Cell --- Stem Cell Transplantations --- Transplantations, Stem Cell --- Stem Cells --- transplantation --- Surgical Procedures --- Procedure, Surgical --- Procedures, Surgical --- Surgical Procedure
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Genetic transformation --- Gene therapy --- Cellular therapy --- Gene Transfer Techniques. --- Genetic Therapy. --- Thérapie génique --- Thérapie cellulaire --- Cellular therapy. --- Gene therapy. --- Genetic transformation. --- Gene Transfer --- Gene Therapy --- Therapy, Gene --- Gene transfer --- Transformation (Genetics) --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Somatic Gene --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Cell therapy --- Cells --- Therapy, Cellular --- Therapeutic use --- Genetic engineering --- Therapeutics --- Genetic recombination --- Microbial genetics --- Nucleic acids --- Transfection --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Gene Transfer. --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Genetic Therapy --- Transgenes --- Genetics --- Gene Therapy. --- Gene Therap. --- Gene Transfer, Horizontal --- Genetic Structures --- Genetic Phenomena --- Recombination, Interspecific --- Gene Transfer, Lateral --- Horizontal Gene Transfer --- Lateral Gene Transfer --- Recombination, Interspecies --- Gene Transfers, Lateral --- Interspecies Recombination --- Interspecific Recombination --- Lateral Gene Transfers --- Thérapie génique. --- Transformation, Genetic. --- Genetic Transformation --- Genetic Transformations --- Transformations, Genetic --- Crosses, Genetic --- Transduction, Genetic --- Immunotherapy, Adoptive --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer
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