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Ataxia Telangiectasia

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Ataxia Telangiectasia --- Cell Fusion --- DNA Replication --- genetics --- radiation effects

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Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.

Research & information: general --- hereditary hemorrhagic telangiectasia --- rare diseases --- telangiectasis --- transforming growth factor-beta (TGF-β) --- Smad pathway --- gastrointestinal bleeding --- epistaxis --- nosebleeds --- tacrolimus --- nasal ointment --- genetic disease --- rare disease --- hereditary hemorrhagic telangiectasia (HHT) --- telangiectases --- mechanical damage --- sun-induced trauma --- vascular malformations --- Endoglin --- activin-receptor-like kinase 1 --- Hereditary Hemorrhagic Telangiectasia --- antithrombotic therapy --- anticoagulants --- antiplatelets --- bleeding --- safety --- HHT --- ALK1 --- endoglin --- raloxifene --- bazedoxifene --- tranexamic acid --- propranolol --- FK506 --- etamsylate --- N-acetylcysteine --- pulmonary arteriovenous malformations --- transcatheter embolotherapy --- screening --- guidelines --- Hereditary hemorrhagic telangiectasia --- pediatrics --- genotype–phenotype correlation --- arteriovenous malformation --- ENG --- ACVRL1 --- SMAD4 --- microRNA --- biomarker --- plasma --- arteriovenous malformations (AVMs) --- angiogenesis --- activin receptor-like kinase 1 (ALK1) --- transforming growth factor beta (TGF-β) --- bone morphogenetic protein (BMP) --- propranolol gel --- epistaxis severity score --- nasal endoscopy --- antiangiogenic properties --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- biomarkers --- endothelial cells --- hereditary hemorrhagic telangiectasia (HHT), second-hit --- arteriovenous malformation (AVM) --- Smad4 --- inflammation --- shear stress --- vascular injury --- somatic mutation --- cell adhesion --- vascular endothelial growth factor (VEGF) --- telangiectasia --- hereditary hemorrhagic --- survival --- life expectancy --- pulmonary arteriovenous malformation --- contrast enhanced magnetic resonance angiography --- liver --- MRI --- ultrasound --- AVM --- bevacizumab --- Osler–Weber–Rendu --- hereditary hemorrhagic telangiectasia/HHT/osler’s disease --- cerebral ischemic lesions --- catheter based embolization therapy

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Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.

Research & information: general --- hereditary hemorrhagic telangiectasia --- rare diseases --- telangiectasis --- transforming growth factor-beta (TGF-β) --- Smad pathway --- gastrointestinal bleeding --- epistaxis --- nosebleeds --- tacrolimus --- nasal ointment --- genetic disease --- rare disease --- hereditary hemorrhagic telangiectasia (HHT) --- telangiectases --- mechanical damage --- sun-induced trauma --- vascular malformations --- Endoglin --- activin-receptor-like kinase 1 --- Hereditary Hemorrhagic Telangiectasia --- antithrombotic therapy --- anticoagulants --- antiplatelets --- bleeding --- safety --- HHT --- ALK1 --- endoglin --- raloxifene --- bazedoxifene --- tranexamic acid --- propranolol --- FK506 --- etamsylate --- N-acetylcysteine --- pulmonary arteriovenous malformations --- transcatheter embolotherapy --- screening --- guidelines --- Hereditary hemorrhagic telangiectasia --- pediatrics --- genotype–phenotype correlation --- arteriovenous malformation --- ENG --- ACVRL1 --- SMAD4 --- microRNA --- biomarker --- plasma --- arteriovenous malformations (AVMs) --- angiogenesis --- activin receptor-like kinase 1 (ALK1) --- transforming growth factor beta (TGF-β) --- bone morphogenetic protein (BMP) --- propranolol gel --- epistaxis severity score --- nasal endoscopy --- antiangiogenic properties --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- biomarkers --- endothelial cells --- hereditary hemorrhagic telangiectasia (HHT), second-hit --- arteriovenous malformation (AVM) --- Smad4 --- inflammation --- shear stress --- vascular injury --- somatic mutation --- cell adhesion --- vascular endothelial growth factor (VEGF) --- telangiectasia --- hereditary hemorrhagic --- survival --- life expectancy --- pulmonary arteriovenous malformation --- contrast enhanced magnetic resonance angiography --- liver --- MRI --- ultrasound --- AVM --- bevacizumab --- Osler–Weber–Rendu --- hereditary hemorrhagic telangiectasia/HHT/osler’s disease --- cerebral ischemic lesions --- catheter based embolization therapy

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The book contains nine articles on the subject of diagnosis and treatment of macular edema due to different causes. It presents both reviews of current recommendations of macular edema treatment as well as original research on specific forms of that entity.

angiogenesis --- angiopoietin-1 --- central serous chorioretinopathy --- proangiogenic factors --- combined treatment --- subthreshold diode micropulse --- anti-VEGF treatment --- diabetic macular edema --- retinal vein occlusion --- Coats disease --- peripheral retinal telangiectasia --- laser photocoagulation --- hypotony maculopathy --- complications of antiglaucoma surgery --- bleb compressive sutures --- age-related macular degeneration --- AMD --- proteomics --- tear film --- tear film proteome --- protein clearance --- neovascularization --- neovascular AMD --- macular edema --- uveitis --- uveitic complications --- non-steroidal anti-inflammatory drugs --- steroids --- biologic treatment --- Irvine–Gass syndrome --- cystoid macular edema --- pseudophakic cystoid macular edema --- NSAIDs corticosteroids --- anti-VEGF --- intravitreal injections --- intravitreal agents --- best corrected visual acuity --- central retinal thickness --- adverse drug reactions --- intravitreal drug expenses