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Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and a new bonus Expert Consult Edition website enables you to search the full text, download all of the book’s images for your personal use, and review periodic updates. New to this edition Features numerous descriptions of the latest clinical strategies—helping you to understand and take advantage of today’s state-of-the-art biotechnology advances. By John Mendelsohn, MD, Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas ; Peter M. Howley, MD, Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts ; Mark A. Israel, MD, Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire; Joe W. Gray, PhD, Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California and Craig B. Thompson, MD, President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York Table of Contents: Part I: Carcinogenesis and Cancer Genetics 1. Cancer, A Genetic Disorder 2. Oncogenes and Signal Transduction 3. Tumor Suppressor Genes 4. Genomic Instability and DNA Repair 5. Epigenetics and Cancer 6. Infectious Agents and Cancer 7. Environmental Carcinogenesis 8. Animal Models: Flies, Fish and Yeast 9. Genetic Mouse Models of Cancer Part II: Cancer Biology 10. Cancer Stem Cells 11. Regulation of the Cell Cycle 12. Cell Growth 13. Cancer Cell Metabolism 14. Apoptosis, Autophagy and Necrosis 15. Cell Growth Arrest and Senescence 16. Stromal-Cancer Interactions in the Microenvironment 17. Hypoxia and Angiogenesis 18. Invasion and Metastasis 19. Inflammation and Cancer 20. Molecular Pathways and Systems Biology Part III: Molecular Pathology and Diagnostics 21. Biomarkers Assessing Risk of Cancer 22. Biomarkers for Detecting Cancer: Molecular Screening 23. Biomarkers for Predicting Response to Specific Therapy 24. The Technology of Analyzing Nucleic Acids 25. Imaging Cancer

Neoplasms --- Molecular Targeted Therapy. --- Molecular Biology --- Molecular biology -- Methods. --- Molecular targeted therapy. --- Neoplasms -- Genetics. --- Neoplasms -- Pathology. --- Medicine --- Health & Biological Sciences --- Oncology --- genetics. --- pathology. --- methods. --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapy, Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Molecular Targeted Therapy

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Cellular signal transduction --- Signal Transduction. --- Molecular Targeted Therapy. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapies, Targeted --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapies, Molecular --- Targeted Therapy, Molecular --- Therapies, Molecular Targeted --- Therapies, Targeted Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- molecular biology --- cell biology --- pharmacology --- medicinal chemistry --- computational chemistry --- systems biology --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Immunoconjugates --- Cell Signaling --- Biology --- Human medicine

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Principles of Molecular Diagnostics and Personalized Cancer Medicine The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today's subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention-all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discuss

Tumors --- Oncology --- Molecular diagnosis. --- Diagnosis --- Molecular diagnostics --- Molecular biology --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Diagnosis. --- Treatment. --- Methodology. --- Molecular aspects --- Individualized Medicine --- Medical Oncology --- Molecular Diagnostic Techniques --- Molecular Targeted Therapy --- Cancer --- Personalized medicine. --- diagnosis --- therapy --- methods --- Individualized medicine --- Personalized medicine --- Medical care --- Pharmacogenetics --- Cancer therapy --- Cancer treatment --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapy, Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Molecular Diagnostic Technics --- Molecular Diagnostic Testing --- Molecular Testing --- Diagnostic Technic, Molecular --- Diagnostic Technics, Molecular --- Diagnostic Technique, Molecular --- Diagnostic Techniques, Molecular --- Diagnostic Testing, Molecular --- Molecular Diagnostic Technic --- Molecular Diagnostic Technique --- Technic, Molecular Diagnostic --- Technics, Molecular Diagnostic --- Technique, Molecular Diagnostic --- Techniques, Molecular Diagnostic --- Testing, Molecular --- Testing, Molecular Diagnostic --- Genetic Testing --- Cytogenetic Analysis --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Therapy

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This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Breast -- Cancer -- Adjuvant treatment. --- Breast neoplasms -- Therapy. --- Medicine. --- Breast --- Neoplasms by Site --- Breast Diseases --- Therapeutics --- Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Skin Diseases --- Diseases --- Skin and Connective Tissue Diseases --- Molecular Targeted Therapy --- Breast Neoplasms --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapy, Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Dermatosis --- Dermatoses --- Skin and Subcutaneous Tissue Disorders --- Skin Disease --- Dermatology --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Endocrine Breast Diseases --- Breast Disease --- Breast Disease, Endocrine --- Breast Diseases, Endocrine --- Disease, Breast --- Disease, Endocrine Breast --- Diseases, Breast --- Diseases, Endocrine Breast --- Endocrine Breast Disease --- Neoplasms by Sites --- Site, Neoplasm --- Sites, Neoplasm --- Neoplasm Site --- Neoplasm Sites --- Breasts --- Chest --- Large-breasted women --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Pharmaceutical Preparations --- Pharmacologic Actions --- Breast Carcinoma --- Cancer of the Breast --- Human Mammary Carcinoma --- Malignant Neoplasm of Breast --- Malignant Tumor of Breast --- Mammary Cancer --- Mammary Carcinoma, Human --- Mammary Neoplasm, Human --- Mammary Neoplasms, Human --- Neoplasms, Breast --- Tumors, Breast --- Breast Cancer --- Breast Tumors --- Cancer of Breast --- Breast Carcinomas --- Breast Malignant Neoplasm --- Breast Malignant Neoplasms --- Breast Malignant Tumor --- Breast Malignant Tumors --- Breast Neoplasm --- Breast Tumor --- Cancer, Breast --- Cancer, Mammary --- Cancers, Mammary --- Carcinoma, Breast --- Carcinoma, Human Mammary --- Carcinomas, Breast --- Carcinomas, Human Mammary --- Human Mammary Carcinomas --- Human Mammary Neoplasm --- Human Mammary Neoplasms --- Mammary Cancers --- Mammary Carcinomas, Human --- Neoplasm, Breast --- Neoplasm, Human Mammary --- Neoplasms, Human Mammary --- Tumor, Breast --- Breast Cancer Lymphedema --- therapy --- drug therapy --- therapeutic use

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This monograph provides the first in-depth study of how mathematical and computational approaches can be used to advance our understanding of cancer therapies and to improve treatment design and outcome. Over the past century, the search for a cancer cure has been a primary occupation of medical researchers. So far, it has led to a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, and most recently, small molecule inhibitors and oncolytic viruses. Each treatment tends to have a certain effectiveness in a specific class of patients, but it is often unclear what exactly causes it to succeed or fail. Recent technological advances have given rise to an ever increasing pool of data and information that highlight the complexity underlying the cancers and their response to treatment. Next to experimental and clinical research, mathematical and computational approaches are becoming an indispensible tool to understand this complexity. Targeted Cancer Treatment in Silico is organized into two parts, corresponding to two types of targeted cancer treatment: small molecule inhibitors and oncolytic viruses. In each part, the authors provide a brief overview of the treatment’s biological basis and present the mathematical methods most suitable for modeling it. Additionally, they discuss how these methods can be applied to answer relevant questions about treatment mechanisms and propose modifications to treatment approaches that may potentially increase success rates. The book is intended for both the applied mathematics and experimental oncology communities, as mathematical models are becoming an increasingly important supplement to laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, it will be a valuable resource for scientists and graduate students alike, and can also serve as an upper-division undergraduate or graduate textbook.

Oncology. --- Cancer --- Mathematics. --- Genetics --- Physiology --- Physiological, Cellular and Medical Topics. --- Mathematical and Computational Biology. --- Genetics and Population Dynamics. --- Applications of Mathematics. --- Biological Therapy --- Computing Methodologies --- Investigative Techniques --- Laboratory Chemicals --- Drug Therapy --- Diseases --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Information Science --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Chemicals and Drugs --- Models, Theoretical --- Molecular Targeted Therapy --- Computer Simulation --- Neoplasms --- Oncolytic Virotherapy --- Small Molecule Libraries --- Biology --- Health & Biological Sciences --- Biology - General --- Research. --- Treatment --- Mathematical models --- Computerized Models --- In Silico --- Computer Models --- Models, Computer --- Computer Model --- Computer Simulations --- Computerized Model --- In Silicos --- Model, Computer --- Model, Computerized --- Models, Computerized --- Silico, In --- Silicos, In --- Simulation, Computer --- Simulations, Computer --- Chemical Libraries --- Molecular Libraries, Small --- Libraries, Chemical --- Libraries, Small Molecular --- Libraries, Small Molecule --- Molecule Libraries, Small --- Small Molecular Libraries --- Oncolytic Virus Therapy --- Virotherapy, Oncolytic --- Oncolytic Virotherapies --- Oncolytic Virus Therapies --- Therapies, Oncolytic Virus --- Therapy, Oncolytic Virus --- Virotherapies, Oncolytic --- Virus Therapies, Oncolytic --- Virus Therapy, Oncolytic --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapies, Targeted --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapies, Molecular --- Targeted Therapy, Molecular --- Therapies, Molecular Targeted --- Therapies, Targeted Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Specialty Chemicals and Products --- Information Sciences --- Science, Information --- Sciences, Information --- Therapy --- Therapeutic --- Therapies --- Treatments --- Disease --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Pharmaceutical Preparations --- Chemicals, Laboratory --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- High Performance Computing --- Methodologies, Computing --- Computing Methodology --- Computing, High Performance --- Methodology, Computing --- Performance Computing, High --- Biologic Therapy --- Biotherapy --- Therapy, Biological --- Biologic Therapies --- Biological Therapies --- Biotherapies --- Therapies, Biologic --- Therapies, Biological --- Therapy, Biologic --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Animal physiology --- Animals --- Math --- Cancer research --- therapy --- drug therapy --- therapeutic use --- Cancer research. --- Applied mathematics. --- Engineering mathematics. --- Biomathematics. --- Cancer Research. --- Mathematical models. --- Oncology  . --- Science --- Anatomy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Mathematics --- Engineering --- Engineering analysis --- Mathematical analysis