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Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis.
Tuberculosis. --- Antigens --- Tuberculosis --- bacterial --- MHC restriction --- TB diagnosis --- T-lymphocyte --- vaccine adjuvant --- Epitopes
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The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burdens of catastrophic expenses on families due to TB. Eliminating TB in the Asia-Pacific region, which has 62% of all estimated TB patients globally, will require innovation, rigorous research, and sustained investment. This special issue connects original research and viewpoints on pertinent approaches for improving TB care and prevention in the Asia-Pacific region.
Humanities --- Social interaction --- pediatric TB --- verbal screening --- contact tracing --- resources --- sputum --- health promotion --- operational research --- indigenous population --- multidrug-resistant tuberculosis --- household contact --- screening --- TB diagnosis --- yield --- operations research --- contacts --- contact investigation --- MDR-TB --- public–private mix model --- public–private partnership --- missing cases --- SORT IT --- TB diagnostics --- laboratory methods --- case detection --- Xpert Ultra --- STR --- Bangladesh regimen --- tuberculosis --- post-tuberculosis morbidity and mortality --- TB preventive therapy --- latent TB infection --- Asia Pacific --- rifapentine-isoniazid --- incidence --- household contacts tracing --- End TB --- sustainable development goals --- South-East Asia --- Western Pacific Region --- national TB program --- socio-economic determinants --- diabetes mellitus --- TB-DM --- adverse drug reactions --- unfavourable outcome --- lymph node TB --- bone TB --- TB elimination --- extrapulmonary tuberculosis --- private sector --- intermediary agency --- referral --- notification --- Viet Nam --- active case finding --- community outreach --- Indonesia --- key population --- innovation --- TB REACH --- community health workers --- mobile X-ray screening --- TB --- chest X-ray --- active TB case-finding --- diagnostic algorithm --- n/a --- public-private mix model --- public-private partnership
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The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burdens of catastrophic expenses on families due to TB. Eliminating TB in the Asia-Pacific region, which has 62% of all estimated TB patients globally, will require innovation, rigorous research, and sustained investment. This special issue connects original research and viewpoints on pertinent approaches for improving TB care and prevention in the Asia-Pacific region.
pediatric TB --- verbal screening --- contact tracing --- resources --- sputum --- health promotion --- operational research --- indigenous population --- multidrug-resistant tuberculosis --- household contact --- screening --- TB diagnosis --- yield --- operations research --- contacts --- contact investigation --- MDR-TB --- public–private mix model --- public–private partnership --- missing cases --- SORT IT --- TB diagnostics --- laboratory methods --- case detection --- Xpert Ultra --- STR --- Bangladesh regimen --- tuberculosis --- post-tuberculosis morbidity and mortality --- TB preventive therapy --- latent TB infection --- Asia Pacific --- rifapentine-isoniazid --- incidence --- household contacts tracing --- End TB --- sustainable development goals --- South-East Asia --- Western Pacific Region --- national TB program --- socio-economic determinants --- diabetes mellitus --- TB-DM --- adverse drug reactions --- unfavourable outcome --- lymph node TB --- bone TB --- TB elimination --- extrapulmonary tuberculosis --- private sector --- intermediary agency --- referral --- notification --- Viet Nam --- active case finding --- community outreach --- Indonesia --- key population --- innovation --- TB REACH --- community health workers --- mobile X-ray screening --- TB --- chest X-ray --- active TB case-finding --- diagnostic algorithm --- n/a --- public-private mix model --- public-private partnership
Choose an application
The World Health Organization’s (WHO) END-TB strategy has set the world on course to climb the highest of medical mountains by 2035, with a targeted peak of reductions in TB deaths by 95%, TB cases by 90%, and no burdens of catastrophic expenses on families due to TB. Eliminating TB in the Asia-Pacific region, which has 62% of all estimated TB patients globally, will require innovation, rigorous research, and sustained investment. This special issue connects original research and viewpoints on pertinent approaches for improving TB care and prevention in the Asia-Pacific region.
Humanities --- Social interaction --- pediatric TB --- verbal screening --- contact tracing --- resources --- sputum --- health promotion --- operational research --- indigenous population --- multidrug-resistant tuberculosis --- household contact --- screening --- TB diagnosis --- yield --- operations research --- contacts --- contact investigation --- MDR-TB --- public-private mix model --- public-private partnership --- missing cases --- SORT IT --- TB diagnostics --- laboratory methods --- case detection --- Xpert Ultra --- STR --- Bangladesh regimen --- tuberculosis --- post-tuberculosis morbidity and mortality --- TB preventive therapy --- latent TB infection --- Asia Pacific --- rifapentine-isoniazid --- incidence --- household contacts tracing --- End TB --- sustainable development goals --- South-East Asia --- Western Pacific Region --- national TB program --- socio-economic determinants --- diabetes mellitus --- TB-DM --- adverse drug reactions --- unfavourable outcome --- lymph node TB --- bone TB --- TB elimination --- extrapulmonary tuberculosis --- private sector --- intermediary agency --- referral --- notification --- Viet Nam --- active case finding --- community outreach --- Indonesia --- key population --- innovation --- TB REACH --- community health workers --- mobile X-ray screening --- TB --- chest X-ray --- active TB case-finding --- diagnostic algorithm --- pediatric TB --- verbal screening --- contact tracing --- resources --- sputum --- health promotion --- operational research --- indigenous population --- multidrug-resistant tuberculosis --- household contact --- screening --- TB diagnosis --- yield --- operations research --- contacts --- contact investigation --- MDR-TB --- public-private mix model --- public-private partnership --- missing cases --- SORT IT --- TB diagnostics --- laboratory methods --- case detection --- Xpert Ultra --- STR --- Bangladesh regimen --- tuberculosis --- post-tuberculosis morbidity and mortality --- TB preventive therapy --- latent TB infection --- Asia Pacific --- rifapentine-isoniazid --- incidence --- household contacts tracing --- End TB --- sustainable development goals --- South-East Asia --- Western Pacific Region --- national TB program --- socio-economic determinants --- diabetes mellitus --- TB-DM --- adverse drug reactions --- unfavourable outcome --- lymph node TB --- bone TB --- TB elimination --- extrapulmonary tuberculosis --- private sector --- intermediary agency --- referral --- notification --- Viet Nam --- active case finding --- community outreach --- Indonesia --- key population --- innovation --- TB REACH --- community health workers --- mobile X-ray screening --- TB --- chest X-ray --- active TB case-finding --- diagnostic algorithm
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