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In this work, a flexible biosensor platform based on impedance spectroscopy and comprising of gold electrodes, polymeric flow cells and a suitable surface modification were developed. Initially, several surface modification techniques described in literature were implemented and optimized for impedimetric biosensors but their individual limitations rendered them unsuitable for this biosensor platform. A novel method based on photobleaching was developed and tested showing satisfactory results.

Mikrofluidik --- electrochemical impedance spectroscopy --- Oberflächenmodifikation --- Biosensor --- surface modification --- photobleaching --- PhotobleichungBiosensor --- microfluidics --- Elektrochemische Impedanzspektroscopie

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Featuring a mild process and high selectivity, enzyme bioelectrocatalysis employing oxidoreductases immobilized on conductive surfaces is playing an increasingly vital role across a wide scope of applications. Enzyme bioelectrocatalysis is key for devices such as biosensors and biofuel cells, which are attracting considerable attention towards sustainable sensing and energy production. A wide range of sophisticated reactions, such as chiral compound synthesis and CO2 and N2 fixation, can be accomplished with enzyme bioelectrocatalysis. Last but not least, redox enzymes are sources of inspiration for new non-noble metal electrocatalysts. The “Enzymatic Bioelectrocatalysis” Special Issue comprises six reviews contributed by research groups from different countries, covering fundamentals and applications, as well as the recent research progress in this field.

Technology: general issues --- Chemical engineering --- bioelectrocatalysts --- oxidoreductases --- biocatalytic reactors --- electrochemical reactors --- bioelectrocatalysis --- nanostructured electrodes --- protein engineering --- bioelectrosynthesis --- photo-bioelectrocatalysis --- membrane protein --- electrode modification --- biofuel cells --- photosynthesis --- liposomes --- hybrid vesicles --- microbial electrosynthesis --- direct electron transfer --- orientation --- carbon nanomaterials --- surface modification --- self-assembled molecular monolayers --- electron transfer --- oxidoreductase --- gold electrode --- metallic nanostructures --- enzyme --- metalloenzyme --- catalysis --- stability --- electrochemistry --- bioelectrochemistry --- bioelectrocatalysts --- oxidoreductases --- biocatalytic reactors --- electrochemical reactors --- bioelectrocatalysis --- nanostructured electrodes --- protein engineering --- bioelectrosynthesis --- photo-bioelectrocatalysis --- membrane protein --- electrode modification --- biofuel cells --- photosynthesis --- liposomes --- hybrid vesicles --- microbial electrosynthesis --- direct electron transfer --- orientation --- carbon nanomaterials --- surface modification --- self-assembled molecular monolayers --- electron transfer --- oxidoreductase --- gold electrode --- metallic nanostructures --- enzyme --- metalloenzyme --- catalysis --- stability --- electrochemistry --- bioelectrochemistry

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Acceptance or rejection of implanted biomaterials is strongly dependent on an appropriate bio-interface between the biomaterial and its surrounding tissue. Given the fact that most bulk materials only provide mechanical stability for the implant and may not interact with tissues and fluids in vivo, surface modification and engineering of biomaterials plays a significant role towards addressing major clinical unmet challenges. Increasing data showed that altering surface properties including physiochemical, topographical, and mechanical characteristics, is a promising approach to tackle these problems. Surface engineering of biomaterials could influence the subsequent tissue and cellular events such as protein adsorption, cellular recolonization, adhesion, proliferation, migration, and the inflammatory response. Moreover, it could be based on mimicking the complex cell structure and environment or hierarchical nature of the bone. In this case, the design of nano/micrometer patterns and morphologies with control over their properties has been receiving the attention of biomaterial scientists due to the promising results for the relevant biomedical applications. This Special Issue presents original research papers that report on the current state-of-the-art in surface engineering of biomaterials, particularly implants and biomedical devices.

Research & information: general --- surface modification --- micro-powder blasting --- aluminum anodization --- micro/nano-structure --- cell culture --- electrophoretic deposition --- enamel remineralization --- bioactive glass --- spectrophotometry --- nanoindentation --- rhBMP-2 --- rhPDGF-BB --- heparin --- implant surface --- osseointegration --- bone regeneration --- beagle dog --- diamond-like carbon --- frictional property --- hydrogen content --- sp2/sp3 ratio --- hydroxyapatite --- titanium implants --- mineralizing solution --- solution plasma treatment

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Featuring a mild process and high selectivity, enzyme bioelectrocatalysis employing oxidoreductases immobilized on conductive surfaces is playing an increasingly vital role across a wide scope of applications. Enzyme bioelectrocatalysis is key for devices such as biosensors and biofuel cells, which are attracting considerable attention towards sustainable sensing and energy production. A wide range of sophisticated reactions, such as chiral compound synthesis and CO2 and N2 fixation, can be accomplished with enzyme bioelectrocatalysis. Last but not least, redox enzymes are sources of inspiration for new non-noble metal electrocatalysts. The “Enzymatic Bioelectrocatalysis” Special Issue comprises six reviews contributed by research groups from different countries, covering fundamentals and applications, as well as the recent research progress in this field.

bioelectrocatalysts --- oxidoreductases --- biocatalytic reactors --- electrochemical reactors --- bioelectrocatalysis --- nanostructured electrodes --- protein engineering --- bioelectrosynthesis --- photo-bioelectrocatalysis --- membrane protein --- electrode modification --- biofuel cells --- photosynthesis --- liposomes --- hybrid vesicles --- microbial electrosynthesis --- direct electron transfer --- orientation --- carbon nanomaterials --- surface modification --- self-assembled molecular monolayers --- electron transfer --- oxidoreductase --- gold electrode --- metallic nanostructures --- enzyme --- metalloenzyme --- catalysis --- stability --- electrochemistry --- bioelectrochemistry --- n/a

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Nano-engineering offers unique solutions for biomedical implants to meet compromised patient conditions via enhanced bioactivity and local drug release. This book presents the cutting-edge nano-engineered dental implant solutions that has the potential to ensure long-term success of dental implants while maintaining clinical translatability. From surface modification of titanium/zirconium dental implants to advanced therapeutic enhancements to treat infection and poor integration, this book advances the field of dental implant nano-engineering, showcasing current trends and future directions.

Technology: general issues --- History of engineering & technology --- endocytosis --- ipriflavone --- mesoporous nanospheres --- nanoparticles --- oxidative stress --- pre-osteoblasts --- implant --- nano-scaled surface --- blood clot --- LncRNA --- osseointegration --- bone regeneration --- zirconium --- zirconia --- dental implants --- nanopores --- electrochemical anodization --- extracellular vesicles --- exosomes --- nanomedicine --- regeneration --- cell-free therapy --- decontamination --- antibacterial agents --- nano-modified dental implant --- nanostructured titanium --- dental implant --- TiO2 nanotubes --- surface modification --- antibacterial --- titanium --- laser therapy --- peri-implantitis --- debridement --- implants --- nanostructure --- gingival fibroblasts --- biofilm --- soft-tissue integration --- endocytosis --- ipriflavone --- mesoporous nanospheres --- nanoparticles --- oxidative stress --- pre-osteoblasts --- implant --- nano-scaled surface --- blood clot --- LncRNA --- osseointegration --- bone regeneration --- zirconium --- zirconia --- dental implants --- nanopores --- electrochemical anodization --- extracellular vesicles --- exosomes --- nanomedicine --- regeneration --- cell-free therapy --- decontamination --- antibacterial agents --- nano-modified dental implant --- nanostructured titanium --- dental implant --- TiO2 nanotubes --- surface modification --- antibacterial --- titanium --- laser therapy --- peri-implantitis --- debridement --- implants --- nanostructure --- gingival fibroblasts --- biofilm --- soft-tissue integration