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Abstract: Practical methods for making laboratory measurements of electroacoustic characteristics of analog and digital telephones, handsets, and headsets are presented. The methods may also be applicable to a wide variety of other communications equipment, including cordless, wireless, and mobile communications devices. Measurement results may be used to evaluate these devices on a standardized basis. Application is in the frequency range from 100 Hz to 8500 Hz. Keywords: analog telephones, digital telephones, electroacoustic measurements on telephones, handsets, headsets, IEEE 269, IEEE 269a, telephony, voice transmission performance.

Telephone --- Equipment and supplies. --- Echo suppressors.

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Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor

Research & information: general --- Biology, life sciences --- soy --- isoflavones --- mammary tumor prevention --- rodent models --- chemical carcinogens --- transgenic mice --- Zebrafish --- Drosophila --- rats --- mice --- NPM-1 --- FLT3 ITD --- ETO-1 --- IDH1/2 --- neural stem cells --- brain and nervous system cancers --- neurogenic niches --- radiotherapy --- sparing of neurogenic regions --- carcinoma --- consensus molecular subtypes --- intestine --- oncogenes --- signaling cascades --- tumor suppressors --- tumorigenesis --- MPN (myeloproliferative neoplasms) --- zebrafish --- iPSCs --- JAK2 --- MPL --- CALR --- thrombosis --- ubiquitin–proteasome system --- cancer --- mouse model --- gene inactivation --- colorectal cancer --- mouse models --- microbiota --- antitumor immunity --- melanoma --- mutation --- genetics --- animal model --- swine --- MeLiM --- progression --- spontaneous regression --- devitalization --- metaplasia --- Cdx --- animal models --- epigenetics --- xenotransplantation --- drug screen --- pre-clinical cancer model --- non-mouse models --- gene editing --- stem cells --- solid tumors --- hematologic malignancies

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

Medicine --- Physiology --- peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.

peroxisome-proliferator activated receptors --- tumor angiogenesis --- tumor progression --- metastasis formation --- endothelial cells --- RNA sequencing --- PPARs --- toxicology --- pharmacology --- ligand --- vascular --- coronary artery --- lipidomics --- eicosanoids --- inflammation --- CYP450 --- peroxisome proliferator-activated receptor --- angiogenesis --- proliferation --- metastasis --- immortality --- resistance to cell death --- growth suppressors --- immune system --- cellular metabolism --- PPAR --- nuclear receptors --- addiction --- alcohol --- nicotine --- opioids --- psychostimulants --- animal models --- human studies --- Alzheimer’s --- risk factors --- PPARα --- lipids --- fatty acids --- modulators --- cognition --- sex --- therapy --- hypertrophic adipocytes --- PPARG isoforms --- PPARG splicing --- dominant-negative isoform --- in vitro adipocytes --- adipogenesis --- hypertrophic obesity --- insulin-resistance --- peroxisome proliferator-activated receptors (PPARs) --- synthetic agonists --- non-alcoholic fatty liver disease (NAFLD) --- non-alcoholic steatohepatitis (NASH) --- fibrosis --- Sirtuin1 --- peroxisome proliferator-activated receptor-γ coactivator-1α --- peroxisome proliferator activated receptors --- obesity --- metabolic syndrome --- vitamin B12 --- folate --- fetal programming --- inherited metabolic disorders --- PGC-1α, disease --- kidney --- cancer --- AKI --- CKD --- nephron --- PKD --- cilia --- cystogenesis --- ligands --- Alzheimer’s disease (AD)

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Plant viruses cause many of the most important diseases threatening crops worldwide. Over the last quarter of a century, an increasing number of plant viruses have emerged in various parts of the world, especially in the tropics and subtropics. As is generally observed for plant viruses, most of the emerging viruses are transmitted horizontally by biological vectors, mainly insects. Reverse genetics using infectious clones—available for many plant viruses—has been used for identification of viral determinants involved in virus–host and virus–vector interactions. Although many studies have identified a number of factors involved in disease development and transmission, the precise mechanisms are unknown for most of the virus–plant–vector combinations. In most cases, the diverse outcomes resulting from virus–virus interactions are poorly understood. Although significant advances have been made towards understand the mechanisms involved in plant resistance to viruses, we are far from being able to apply this knowledge to protect cultivated plants from the all viral threats.The aim of this Special Issue was to provide a platform for researchers interested in plant virology to share their recent results. To achieve this, we invited the plant virology community to submit research articles, short communications and reviews related to the various aspects of plant virology: ecology, virus–plant host interactions, virus–vector interactions, virus–virus interactions, and control strategies. This issue contains some of the best current research in plant virology.

Research & information: general --- Biology, life sciences --- whitefly --- begomovirus --- Vta1 --- virus transmission --- coat proteins --- membrane association --- topology --- cilevirus --- movement protein --- p29 capsid protein --- barley yellow dwarf virus --- BYDV --- wheat --- barley --- yield loss --- vectors --- aphids --- persistent virus --- Amalgaviridae --- synergism --- antagonism --- vsiRNAs --- miRNAs --- mixed-infections --- Arabidopsis thaliana --- Cucumber mosaic virus --- genome-wide association studies --- plant–virus interaction --- seed transmission --- virulence --- callose --- coat protein --- plasmodesmata --- triple gene block --- viral suppressor --- virus movement --- virus replication complex --- TYLCD --- TYLCV --- tomato --- Solanum lycopersicum --- disease resistance --- plant breeding --- PAMP-triggered immunity --- effector-triggered immunity --- RNA silencing --- viral suppressors --- NIK1 --- PTI --- ETI --- geminiviruses --- host jumping --- viral evolution --- trade-off --- plant virus --- RNA virus --- potyvirus --- Plum pox virus --- VPg --- eIF4E --- high-throughput sequencing --- bioinformatics --- detection --- discovery --- MinION --- nanopore sequencing --- rolling circle amplification --- viral metagenomics --- CRESS DNA --- capulavirus --- homopolymer --- Begomovirus --- cucumber --- mechanical inoculation --- real-time PCR --- viral load --- QTLs --- resistance --- Geminiviridae --- sweepoviruses --- DNA satellites --- Deltasatellite --- helper virus range --- transreplication --- high-throughput sequencing (HTS) --- virus --- dsRNA --- total RNA --- OLV1 --- LRNV --- ToFBV --- ASGV --- host adaptation --- virus evolution --- n/a --- plant-virus interaction