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This is the first book to focus on the latest developments in hyphenated techniques using supercritical fluids. The advantages of SFC in hyphenation with various detection modes, such as FTIR, MS, MPD and ICP and others are clearly featured throughout the book. Special attention is paid to coupling of SFE with GC or SFC. In this edited volume, chapters are written by leading experts in the field. The book will be of interest to professionals in academia, as well as to those researchers working in an industrial environment, such as analytical instrumentation, pharmaceuticals, agricult
Supercritical fluid chromatography. --- Supercritical fluid extraction. --- Supercritical fluid chromatography --- Supercritical fluid extraction --- Chromatographie en phase supercritique --- Extraction par fluides supercritiques --- SFE (Chemical extraction) --- Extraction (Chemistry) --- SFC (Chromatography) --- Supercritical gas chromatography --- Gas chromatography
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Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable "go-to" reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a 'green' way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing.
Drugs --- Pharmacy --- Supercritical fluid chromatography. --- Research --- Methodology. --- SFC (Chromatography) --- Supercritical gas chromatography --- Gas chromatography --- Chemistry --- Medicine --- Materia medica --- Pharmacology --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Chromatography, Supercritical Fluid --- Drug Development --- Pharmaceutical Research --- methods
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Because of their unique properties and relatively low environmental impact, supercritical fluids have proven highly useful in the extraction and separation of organic compounds, in particle production, as reaction media, and for the destruction of toxic waste. In Supercritical Fluid Methods and Protocols, experienced practitioners present detailed accounts of a wide variety of techniques using supercritical fluids. These range from the supercritical fluid extraction methods for numerous compounds to the ninhydrin staining of fingerprints on checks and banknotes, and from the detection of impurities in pharmaceuticals to a wide variety of applications throughout environmental and food science, and across analytical, clinical, and medicinal chemistry. Detailed step-by-step instructions enable users to apply these essential techniques successfully the first time, and include modifications that permit their effective adaptation to novel experimental or process conditions. For each application, additional discussions provide needed background information, lists of materials and apparatus, and advice about common pitfalls and how to avoid them. Versatile and comprehensive, Supercritical Methods and Protocols offers both novice and experienced investigators and laboratory analysts powerful tools that will enable successful biological and bioprocess analyses and optimizations today.
Biomolecules -- Separation -- Laboratory manuals. --- Electronic books. -- local. --- Supercritical fluid chromatography -- Laboratory manuals. --- Supercritical fluid extraction -- Laboratory manuals. --- Supercritical fluid extraction --- Supercritical fluid chromatography --- Biomolecules --- Biotechnology --- Chromatography, Supercritical Fluid --- Biological Science Disciplines --- Technology --- Chromatography --- Technology, Industry, and Agriculture --- Natural Science Disciplines --- Chemistry Techniques, Analytical --- Investigative Techniques --- Disciplines and Occupations --- Technology, Industry, Agriculture --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Separation --- Biological molecules --- Molecules --- Molecular biology --- SFC (Chromatography) --- Supercritical gas chromatography --- Gas chromatography --- SFE (Chemical extraction) --- Extraction (Chemistry) --- Analytical biochemistry. --- Analytical Chemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry
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