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Post-weaning social isolation of rats produces psychological and physiological changes that are relevant to schizophrenia. Here, we report that long-term potentiation (LTP) in the CA1 to subiculum pathway is lower by 34%, (P<0.0001) in brain slices from isolates compared with those from socially housed rats. We also report that LTP in this pathway is NMDA receptor-dependent. (C) 2003 Elsevier B.V. All rights reserved

Abnormalities. --- Acoustic startle. --- Brain. --- Ca1. --- Cognitive impairment. --- Expression. --- Hippocampal-formation. --- Isolation. --- Long-term potentiation. --- Long-term. --- Ltp. --- Nmda receptor. --- Nucleus-accumbens. --- Physiological. --- Post weaning. --- Potentiation. --- Prepulse inhibition. --- Projections. --- Rat. --- Rats. --- Schizophrenia. --- Slices. --- Social isolation. --- Social-isolation. --- Social. --- Subfields. --- Subiculum. --- Time.