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HLA-DQ Antigens --- HLA-DR Antigens --- Hematopoietic Stem Cell Transplantation. --- Histocompatibility Testing --- T-Lymphocytes, Cytotoxic --- Isoantibodies --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- immunology. --- methods. --- biosynthesis. --- transplantation --- Theses --- Hematopoietic Stem Cell Transplantation --- immunology --- methods --- biosynthesis

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Hematopoietic Stem Cell Transplantation. --- Transplantation Immunology. --- Hematopoietic stem cells --- Cellules souches hématopoïétiques --- Transplantation. --- Transplantation --- Hematopoietic Stem Cell Transplantation --- Transplantation Immunology --- Immunology, Transplantation --- Organ Transplantation --- Tissue Transplantation --- Cell Transplantation --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- transplantation

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Bone marrow --- Hematopoietic stem cells --- Moelle osseuse --- Cellules souches hématopoïétiques --- Sang. --- Moelle osseuse. --- Greffe (Chirurgie) --- Bone Marrow Transplantation. --- Hematopoietic Stem Cell Transplantation. --- Transplantation --- Greffe --- Transplantation. --- Bone Marrow Transplantation --- Hematopoietic Stem Cell Transplantation --- HSCs (Hematopoietic stem cells) --- Marrow --- Medulla ossium --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Cell Transplantation --- Grafting, Bone Marrow --- Transplantation, Bone Marrow --- Transplantation, Bone Marrow Cell --- Bone Marrow Grafting --- Bone Marrow --- Bone Marrow Cells --- transplantation --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells --- Immune system --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization

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Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features * Comprehensive review by leading researchers * Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules * Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy * Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues.

Hematopoietic Stem Cell Transplantation. --- Gene therapy. --- Immunotherapy. --- Cellular therapy. --- Hematopoietic stem cells --- Thérapie cellulaire --- Cellules souches hématopoïétiques --- Transplantation. --- Transplantation --- Stem Cell Transplantation --- Hematopoietic Stem Cell Transplantation --- Cell Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- General Surgery --- Transplantations --- Transplantation Immunology --- Transplantation Conditioning --- Transplantation, Cell --- Cells --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- Transplantation, Stem Cell --- Stem Cell Transplantations --- Transplantations, Stem Cell --- Stem Cells --- transplantation --- Surgical Procedures --- Procedure, Surgical --- Procedures, Surgical --- Surgical Procedure

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This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations. The book covers a wide range of practical implementation tools including HSCT program team structure, building inpatient and outpatient HSCT units, requisite laboratory support for transplantation program, practical aspects of stem cell collection and processing, HSCT program quality management, education and training, and data management. The book also addresses cost effectiveness and recommendations for establishing transplantation program in countries with limited resources.  Written by group of internationally established experts in their corresponding hematopoietic stem cell transplantation fields, with contributions from many leaders of hematopoietic stem cell transplantation organizations, Establishing a Hematopoietic Stem Cell Transplantation Unit: A Practical Guide is an essential, practical resource for all members of the multidisciplinary hematopoietic stem cell transplantation team.

Medicine. --- Blood transfusion. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Blood Transfusion Medicine. --- Hematopoietic stem cells --- Transplantation. --- Oncology  . --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Tumors --- Haematology --- Internal medicine --- Blood --- Transfusion committees --- Diseases --- Hematopoietic Stem Cell Transplantation/ --- Health Facilities. --- Health Facility Planning. --- Health Facility Conversion --- Planning, Health Facility --- Conversion, Health Facility --- Conversions, Health Facility --- Facility Conversion, Health --- Facility Conversions, Health --- Facility Planning, Health --- Facility Plannings, Health --- Health Facility Conversions --- Health Facility Plannings --- Plannings, Health Facility --- Facilities, Health --- Facility, Health --- Health Facility --- Transplantation, Hematopoietic Stem Cell --- Stem Cell Transplantation, Hematopoietic --- Hematopoietic Stem Cells --- Bone Marrow Transplantation --- Bone Marrow Purging --- Hematopoietic Stem Cell Mobilization --- transplantation --- Transfusion.