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"Interest in status epilepticus--the most extreme form of epilepsy, involving continuous seizures--has surged in the last 20 years. Since 1979 there have been over 4,000 publications on the subject, including more than 1,700 in the last five years. No other text provides such a comprehensive review of the recent advances in the field of status epilepticus. The book focuses on the two areas in which progress has been most rapid: basic mechanisms and treatment. There is now a greater understanding of the mechanisms and complications of status epilepticus at the molecular level, which should eventually lead to improved therapy, and treatment strategies today have a greater sense of urgency because of the realization that neuronal apoptosis and necrosis can be triggered very quickly. After an overview of history, classification, and epidemiology, the contributors consider clinical phenomenology, biological markers, pathophysiology, brain damage, epileptogenesis, therapeutic principles, pharmacology, and therapeutic management. Their contributions are equally divided between studies of basic mechanisms in animal models and clinical studies, so that the reader can turn easily from the reductionist experiment that isolates a small component of status to the complex clinical situation in which these principles can translate into therapeutic action. The goal is to provide a scientific rationale for clinical decisions while developing therapeutic attitudes that are firmly grounded in pathophysiology"--MIT CogNet.

Epilepsy --- Convulsions --- Status Epilepticus --- Brain Diseases --- Central Nervous System Diseases --- Nervous System Diseases --- Diseases --- Neurology --- Medicine --- Health & Biological Sciences --- Treatment --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- CNS Diseases --- Central Nervous System Disorders --- CNS Disease --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Epilepsy, Cryptogenic --- Seizures, Epileptic --- Single Seizure --- Aura --- Awakening Epilepsy --- Epileptic Seizures --- Seizure Disorder --- Auras --- Cryptogenic Epilepsies --- Cryptogenic Epilepsy --- Epilepsies --- Epilepsies, Cryptogenic --- Epilepsy, Awakening --- Epileptic Seizure --- Seizure Disorders --- Seizure, Epileptic --- Seizure, Single --- Seizures, Single --- Single Seizures --- Grand Mal Status Epilepticus --- Status Epilepticus, Complex Partial --- Status Epilepticus, Electrographic --- Status Epilepticus, Generalized --- Status Epilepticus, Generalized Convulsive --- Status Epilepticus, Grand Mal --- Status Epilepticus, Non-Convulsive --- Status Epilepticus, Simple Partial --- Status Epilepticus, Subclinical --- Absence Status --- Complex Partial Status Epilepticus --- Generalized Convulsive Status Epilepticus --- Non-Convulsive Status Epilepticus --- Petit Mal Status --- Simple Partial Status Epilepticus --- Electrographic Status Epilepticus --- Generalized Status Epilepticus --- Non Convulsive Status Epilepticus --- Status Epilepticus, Non Convulsive --- Status, Absence --- Status, Petit Mal --- Subclinical Status Epilepticus --- Convulsive disorders --- Convulsive seizures --- Seizures, Convulsive --- Seizures --- Nervous system --- Spasms --- Brain --- Developmental disabilities --- Epilepsy. --- Convulsions. --- Treatment. --- NEUROSCIENCE/General