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An important, open research topic today is to understand the relevance that dark matter halo substructure may have for dark matter searches. In the standard cosmological model, halo substructure or subhalos are predicted to be largely abundant inside larger halos, for example, galaxies such as ours, and are thought to form first and later merge to form larger structures. Dwarf satellite galaxies—the most massive exponents of halo substructure in our own galaxy—are already known to be excellent targets for dark matter searches, and indeed, they are constantly scrutinized by current gamma-ray experiments in the search for dark matter signals. Lighter subhalos not massive enough to have a visible counterpart of stars and gas may be good targets as well, given their typical abundances and distances. In addition, the clumpy distribution of subhalos residing in larger halos may boost the dark matter signals considerably. In an era in which gamma-ray experiments possess, for the first time, the exciting potential to put to test the preferred dark matter particle theories, a profound knowledge of dark matter astrophysical targets and scenarios is mandatory should we aim for accurate predictions of dark matter-induced fluxes for investing significant telescope observing time on selected targets and for deriving robust conclusions from our dark matter search efforts. In this regard, a precise characterization of the statistical and structural properties of subhalos becomes critical. In this Special Issue, we aim to summarize where we stand today on our knowledge of the different aspects of the dark matter halo substructure; to identify what are the remaining big questions, and how we could address these; and, by doing so, to find new avenues for research.
gamma rays --- indirect searches. --- semi-analytic modeling --- cosmological model --- indirect dark matter searches --- particle dark matter --- indirect detection --- gamma-rays and neutrinos --- galactic subhalos --- indirect searches --- statistical data analysis --- subhalo boost --- dark matter halos --- halo substructure --- structure formation --- dark matter annihilation --- dark matter searches --- dwarf spheroidal satellite galaxies --- galactic sub-halos --- subhalos --- dwarf spheroidal galaxies --- gamma-rays --- cosmological N-body simulations --- dark matter
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This book builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions.
DNA fingerprinting --- Moral and ethical aspects. --- DNA fingerprints --- DNA identification --- DNA profiles --- DNA profiling --- Genetic fingerprinting --- Genetic fingerprints --- Forensic genetics --- Identification --- Technique --- Data Interpretation, Statistical --- Forensic Genetics --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- methods --- DNA Fingerprinting --- DNA --- physiology
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Recent years have seen an explosion in new kinds of data on infectious diseases, including data on social contacts, whole genome sequences of pathogens, biomarkers for susceptibility to infection, serological panel data, and surveillance data. The Handbook of Infectious Disease Data Analysis provides an overview of many key statistical methods that have been developed in response to such new data streams and the associated ability to address key scientific and epidemiological questions. A unique feature of the Handbook is the wide range of topics covered. Key features Contributors include many leading researchers in the field Divided into four main sections: Basic concepts, Analysis of Outbreak Data, Analysis of Seroprevalence Data, Analysis of Surveillance Data Numerous case studies and examples throughout Provides both introductory material and key reference material
Biomathematics. Biometry. Biostatistics --- Epidemiology --- Infectious diseases. Communicable diseases --- Communicable diseases --- Communicable Diseases --- Data Analysis --- Data Interpretation, Statistical --- Infectious Diseases --- Communicable Disease --- Disease, Communicable --- Disease, Infectious --- Diseases, Communicable --- Diseases, Infectious --- Infectious Disease --- Disease Outbreaks --- Disease Transmission, Infectious --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Analyses, Data --- Analysis, Data --- Data Analyses
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Epidemiology --- Data Interpretation, Statistical --- Epidemiologic Methods --- Statistical methods --- Data Interpretation, Statistical. --- Epidemiologic Methods. --- 614.4 --- -ABB9205 --- 10.02.a --- Diseases --- Public health --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Sociale hygiëne. Epidemiologie--(volksgezondheid) --- Statistieken ; Algemeen --- methods --- Statistical methods. --- Epidemiology - Statistical methods. --- Epidemiology - Statistical methods
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Medicial statistics --- Statistics --- Data Interpretation, Statistical --- Statistical methods --- methods --- Statistics as Topic --- Data Interpretation, Statistical. --- 519.24 --- -Medicine --- -Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- methods. --- Special statistical applications and models --- -methods. --- 519.24 Special statistical applications and models --- -519.24 Special statistical applications and models --- Clinical sciences --- Medical statistics --- Health --- Health statistics --- Medicine
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Data Interpretation, Statistical. --- Mutagenicity Tests. --- Mutagens --- Mutagenicity testing --- -Mutagen testing --- Mutagenesis --- Chronic toxicity testing --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- toxicity. --- Statistical methods --- Testing --- Statistical methods. --- -toxicity. --- Data Interpretation, Statistical --- Mutagenicity Tests --- Mutagen testing --- toxicity
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Cancer --- Clinical trials --- Clinical Trials as Topic --- Data Collection --- Data Interpretation, Statistical. --- Neoplasms --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Treatment&delete& --- Evaluation&delete& --- Data processing --- methods --- therapy --- Research --- Mathematical statistics --- Data Interpretation, Statistical --- Treatment --- Evaluation
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This essential book details intermediate-level statistical methods and frameworks for the clinician and medical researcher with an elementary grasp of health statistics and focuses on selecting the appropriate statistical method for many scenarios. Detailed evaluation of various methodologies familiarizes readers with the available techniques and equips them with the tools to select the best from a range of options. The inclusion of a hypothetical case study between a clinician and statistician charting the conception of the research idea through to results dissemination enables the reader to understand how to apply the concepts covered into their day-to-day clinical practice. Applied Statistical Considerations for Clinical Researchers focuses on how clinicians can approach statistical issues when confronted with a medical research problem by considering the data structure, how this relates to their study's aims and any potential knock-on effects relating to the evidence required to make correct clinical decisions. It covers the application of intermediate-level techniques in health statistics making it an ideal resource for the clinician seeking an up-to-date resource on the topic.
Medicine --- Medical statistics --- Research --- Statistical methods. --- Research Personnel. --- Data Interpretation, Statistical. --- Health --- Health statistics --- Statistics --- Health Workforce --- Statistical methods --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Investigator, Clinical --- Investigators --- Investigators, Clinical --- Survey Personnel --- Clinical Investigator --- Clinical Investigators --- Researchers --- Investigator --- Personnel, Research --- Personnel, Survey --- Researcher --- Medical informatics. --- Biometry. --- Bioinformatics. --- Biology --- Health Informatics. --- Biostatistics. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Biological statistics --- Biometrics (Biology) --- Biostatistics --- Biomathematics --- Clinical informatics --- Health informatics --- Medical information science --- Data processing
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Mathematical statistics --- Data Interpretation, Statistical --- Models, Statistical --- Probabilities --- Statistique mathématique --- Probabilités --- Periodicals --- Périodiques --- Mathematical statistics. --- Mathematical Sciences --- Applied Mathematics --- General and Others --- Numerical Analysis --- Statistics --- gegevensanalyse --- Mathematics --- Statistical inference --- Statistics, Mathematical --- Sampling (Statistics) --- Statistical methods --- Model, Statistical --- Models, Binomial --- Models, Polynomial --- Statistical Model --- Probabilistic Models --- Statistical Models --- Two-Parameter Models --- Binomial Model --- Binomial Models --- Model, Binomial --- Model, Polynomial --- Model, Probabilistic --- Model, Two-Parameter --- Models, Probabilistic --- Models, Two-Parameter --- Polynomial Model --- Polynomial Models --- Probabilistic Model --- Two Parameter Models --- Two-Parameter Model --- Statistics as Topic --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Data Interpretation, Statistical. --- Models, Statistical.
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"Very little in our human experience is truly comparable to the immensely crowded and bustling interior of a cell. Biological numeracy provides a new kind of understanding of the cellular world. This book brings together up-to-date quantitative data from the vast biological literature and uses the powerful tool of "back of the envelope" estimates to reveal fresh perspectives and insights from numbers commonly encountered in cell biology. Readers gain a feeling for the sizes, concentrations, energies, and rates that characterize the lives of cells - thereby shedding new light on the microscopic realm."--Publisher's description.
Biomathematics. Biometry. Biostatistics --- Histology. Cytology --- Cells --- Cellular Structures. --- Data Interpretation, Statistical. --- Basic Sciences. Biology --- ultrastructure. --- Cellular Biology --- Cellular Biology. --- Ultrastructure. --- Cytology --- Cell physiology --- Cellular Structures --- Data Interpretation, Statistical --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Data Interpretations, Statistical --- Interpretation, Statistical Data --- Statistical Data Analysis --- Statistical Data Interpretation --- Data Analysis, Statistical --- Analyses, Statistical Data --- Analysis, Statistical Data --- Data Analyses, Statistical --- Interpretations, Statistical Data --- Statistical Data Analyses --- Statistical Data Interpretations --- Cell Components --- Cell Component --- Cellular Structure --- Component, Cell --- Components, Cell --- Structure, Cellular --- Structures, Cellular --- Cell function --- Physiology --- Data processing --- ultrastructure --- 576.32/.36 --- 576.32/.36 Cell physiology. Cell biochemistry. Cell biophysics. Molecular biology of the cell --- Cell physiology. Cell biochemistry. Cell biophysics. Molecular biology of the cell
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