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Chemistry --- stamcellen
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For the third edition of this work Dr. Rao and his fellow editors have worked diligently with the contributors to revise and expand each chapter. Additional information about our understanding of the differentiation of pluripotent stem cells into the various neural cell types has been included. Particular attention has been focused on the chapters describing retinal epithelium and neuroglial differentiation, as these cells are currently being delivered in early phase clinical trials. Given the recent findings about the importance of cell death in tumorigenesis, the issue of cell death regulation in the nervous system has been further explored. The issue of transdifferentiation has also been discussed and extensively updated given the recent findings on direct differentiation and reprogramming of cells.
Neuropathology --- neurologie --- stamcellen
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For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications. Translational Stem Cell Research is broken into ten sections. It opens with an overview of the latest in stem cell research, focusing on specific diseases and the treatment of burn victims. Part II discusses the issues involved in the many steps from bench to bedside, ranging from first research in vitro to clinical trials. Part III covers scientific, regulatory and ethical challenges to basic research, and Part IV details issues regarding stem cell banks. Part V explores ethical, economic and strategic issues involved in collaboration between universities and industry, and Part VI addresses legal problems raised by patents on human stem-cell based inventions plus the extent to which there can be technological solutions to a moral dilemma. Part VII presents imaginative ways of communicating research to the general public and how to create conditions for a constructive dialogue. Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees. The book closes with a look into the future of translational stem cell research and stem cell-based therapeutic applications.
Histology. Cytology --- stamcellen --- stamceltransplantatie
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There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.
Histology. Cytology --- stamcellen --- stamceltransplantatie
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As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson's disease, Huntington's disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body's own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.
Neuropathology --- neurologie --- stamcellen
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Stomatology --- stamcellen --- stomatologie
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Ophthalmology --- stamcellen --- oftalmologie
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Neuropathology --- neurologie --- stamcellen
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Histology. Cytology --- stamcellen --- stamceltransplantatie
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De natuur heeft talloze manieren ontwikkeld waarop dieren vorst kunnen overleven. Poolvissen hebben speciale eiwitten in hun bloed die ervoor zorgen dat het blijft stromen als het zeewater 2 °C onder nul is. Sommige poolinsecten bestaan voor bijna een kwart uit glycerol, een bekend antivriesmiddel. Canadese kikkers zijn s winters maandenlang bevroren, maar ontwaken in het voorjaar springlevend dankzij bepaalde beschermende suikers. En ook mensen bestrijden ijs op veel verschillende manieren. Strooizout zorgt ervoor dat Nederland in de winter niet stilstaat, en glycol houdt de radiator aan de praat. Spermabanken en stamcelbanken zouden niet bestaan zonder vorstbeschermende stoffen. En om kinderwensen te vervullen zijn wetenschappers steeds op zoek naar nieuwe methoden om eicellen en embryos veilig in te vriezen.
Chemistry --- vorstbeveiligers --- stamcellen --- chemie
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