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Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-renewal potential is inversely related to the stratified differentiation program. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on significant variations of squamous cell carcinoma, including squamous cell carcinoma of the vagina, bladder, head and neck.

Squamous cell carcinoma.

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Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-renewal potential is inversely related to the stratified differentiation program. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on significant variations of squamous cell carcinoma, including squamous cell carcinoma of the vagina, bladder, head and neck.

Squamous cell carcinoma.

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This dissertation explores the impact of proteins Survivin and WRAP53β, along with hypoxia, on the treatment response in head and neck squamous cell carcinoma (HNSCC). It aims to identify potential biomarkers that can predict treatment outcomes, facilitating personalized treatment plans. The research highlights the correlation between high expression of Survivin and nuclear WRAP53β with improved responses to radiotherapy and overall survival. Additionally, the study examines the effects of hypoxia on treatment response and the induction of cancer stem cells, suggesting that hypoxia may have varying impacts depending on the tumor's characteristics. This work is intended for oncologists and clinical researchers focused on cancer treatment and biomarker development.

Squamous cell carcinoma. --- Radiotherapy.

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This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC.

Squamous cell carcinoma. --- SCC (Oncology) --- Squamous cell cancer --- Cancer --- Oncology

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Carcinoma, Squamous Cell --- Penile Neoplasms --- therapy --- therapy