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Spondyloarthropathies.

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The first section of the book entitled Clinical and Molecular Advances in Ankylosing Spondylitis is a review of the clinical manifestations of Ankylosing Spondylitis (AS) and Spondyloarthritis (SpA). The book includes chapters on Bone Mineral Density measurements, two chapters on the temporomandibular joints, axial fractures, clinical manifestations, diagnosis, and treatment. Molecular genetics and immune response are analyzed in the second section of the book; information on HLA-B*27, other MHC genes and the immune response of AS patients to bacteria is reviewed and updated. Two chapters are dedicated to recent information on non-MHC genes in AS susceptibility, and to new data on disease pathways generated from gene expression studies on peripheral blood.

Ankylosing spondylitis. --- Bechterew's disease --- Bekhterev's disease --- Marie-Struempell disease --- Marie-Strümpell spondylitis --- Rheumatoid spondylitis --- Spondylarthritis ankylopoietica --- Spondylitis ankylopoietica --- Ankylosis --- Spondylitis --- Spondyloarthropathies --- Immunology

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It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize this growing knowledge and present all the current studies concerning the basic research of SpA. Over the last decade, enormous progress has been made in the understanding of the molecular and cellular processes that lead to disease pathology. Recognition of the pathways involved in the pathogenic mechanisms of disease and the potential to target specific immune effector functions have opened the door to a wide range of innovative treatment opportunities for the SpA. Thus, we believe that the understanding of the specific molecular mechanisms involved would help to design highly specific drugs in the future. The contributors are among the best in their field and reflect the state of the art of research and current opinion of rheumatologists and immunologists.

Spondyloarthropathies --Molecular aspects. --- Spondyloarthropathies --- Spondylarthropathies --- Genetics --- Spondylarthritis --- Biology --- Biological Science Disciplines --- Arthritis --- Spondylitis --- Natural Science Disciplines --- Spinal Diseases --- Joint Diseases --- Musculoskeletal Diseases --- Disciplines and Occupations --- Bone Diseases --- Diseases --- Molecular aspects --- Molecular aspects. --- Spondylarthritides --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Spine --- Health Workforce --- Biomedicine, general.

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Ankylosing spondilitis is a chronic form of arthritis known to affect around 1 in 200 people (over 1 million sufferers in the USA alone). No cure has yet been found for the disease, however, early diagnosis and proper medical management can be important in reducing the risk of disability and deformity. Ankylosing spondilitis: the facts is the first mass market book to be published on this important disease. It provides clear and accessible information on treatment, diagnosis, genetic counselling, and daily life with this illness. Professor Khan is one of the leading experts in the world on AS, while also suffering from it. This combination of scientific knowledge and personal experience of a debilitating disorder results in a unique book which will prove invaluable for sufferers wishing toknow more about their condition, and those that share their lives.

Ankylosing spondylitis --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Bechterew's disease --- Bekhterev's disease --- Marie-Struempell disease --- Marie-Strümpell spondylitis --- Rheumatoid spondylitis --- Spondylarthritis ankylopoietica --- Spondylitis ankylopoietica --- Ankylosis --- Spondylitis --- Spondyloarthropathies

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Ankylosing spondylitis is a chronic form of arthritis known to affect around 1 in 200 people (over 1 million sufferers in the USA alone). No cure has yet been found for the disease, however, early diagnosis and proper medical management can be important in reducing the risk of disability and deformity.   Ankylosing Spondylitis in Clinical Practice is a concise, practical guide on the diagnosis and management of this debilitating condition. The chapters cover all relevant issues including:   Epidemiology of ankylosing spondylitis Genetics of ankylosing spondylitis Clinical manifestations of ankylosing spondylitis Diagnosis of ankylosing spondylitis Imaging in ankylosing spondylitis Management of ankylosing spondylitis including non-drug and drug treatment options Socioeconomic aspects of ankylosing spondylitis   This book is aimed at clinicians who treat ankylosing spondylitis. It provides an authoritative, accessible guide to the diagnosis, management and treatment of ankylosing spondylitis.

Ankylosing spondylitis. --- Spondylitis, Ankylosing. --- Ankylosing spondylitis --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Musculoskeletal System Diseases --- Surgery - General and By Type --- Orthopedics. --- Pain medicine. --- Rheumatology. --- Orthopaedics --- Orthopedia --- Bechterew's disease --- Bekhterev's disease --- Marie-Struempell disease --- Marie-Strümpell spondylitis --- Rheumatoid spondylitis --- Spondylarthritis ankylopoietica --- Spondylitis ankylopoietica --- Medicine. --- Medicine & Public Health. --- Pain Medicine. --- Internal medicine --- Connective tissues --- Joints --- Surgery --- Diseases --- Ankylosis --- Spondylitis --- Spondyloarthropathies --- Algiatry