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The somatotrophic axis in brain function
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ISBN: 9780120884841 0120884844 9780080498164 0080498167 9786611010799 1281010790 Year: 2006 Publisher: Amsterdam ; Boston : Elsevier Academic Press,

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Abstract

The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being red

Growth hormone secretagogues : basic findings and clinical implications
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ISBN: 0444829334 9780444829337 1283272741 9781283272742 9780080532691 0080532691 9786613272744 Year: 1999 Publisher: Amsterdam ; New York : Elsevier,

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Abstract

Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities. There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field o

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