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"Small-angle scattering (SAS) is a scattering technique based on deflection of collimated radiation away from the straight trajectory after it interacts with structures that are much larger than the wavelength of the radiation. The most important feature of the SAS method is its potential for analyzing the inner structure of disordered systems, and frequently the application of this method is a unique way to obtain direct structural information on systems with random arrangement of density inhomogeneities in such large-scale. The SAS technique, with its well-developed experimental and theoretical procedures and wide range of studied objects, is a self-contained branch of the structural analysis of matter."--

Small-angle scattering.

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Enzymology.. --- Molecular structure. --- Small-angle scattering.

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This dissertation by Francesca Caporaletti explores the interactions of the proteins MYC and MexR with DNA using Small Angle Scattering (SAS) techniques. The study focuses on understanding the regulatory mechanisms of these protein-DNA complexes, which play crucial roles in biological processes such as antibiotic resistance in Pseudomonas aeruginosa and the regulation of cell growth in cancer. By utilizing Small Angle X-Ray Scattering (SAXS) and Small Angle Neutron Scattering (SANS), the research provides insights into the structural dynamics of these complexes in their native states. The work aims to advance knowledge in the field of protein-DNA interactions, with implications for health and disease.

DNA-protein interactions. --- Small-angle scattering. --- DNA-protein interactions --- Small-angle scattering

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Describing all aspects of the technique of small-angle scattering of X-rays and neutrons, this book covers topics including instrumentation, sample requirements, data interpretation and modelling methods. Examining each in a comprehensive way, the text also gives examples of applications in various fields of biophysics and biochemistry.

X-rays --- Small-angle x-ray scattering. --- Scattering, Small-angle x-ray --- X-ray small-angle scattering --- Small-angle scattering --- X-ray scattering --- Scattering (Physics) --- Scattering. --- Scattering --- Macromolecules --- Neutrons --- Structure. --- Measurement.

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This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for exploring the diversity of solution SAS methods and applications. Chapter 3 of this book is available open access under a CC BY 4.0 license at link.springer.com.

Life sciences. --- Molecular biology. --- Biotechnology. --- Proteins. --- Life Sciences. --- Protein Structure. --- Molecular Medicine. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Chemical engineering --- Genetic engineering --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology --- Biosciences --- Sciences, Life --- Science --- Small-angle scattering. --- Small-angle x-ray scattering. --- Scattering, Small-angle x-ray --- X-ray small-angle scattering --- Small-angle scattering --- X-rays --- Low-angle scattering --- Scattering, Low-angle --- Scattering, Small-angle --- Scattering (Physics) --- Scattering --- Biochemistry. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Health Workforce --- Proteins .