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Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.

Sjogren's syndrome. --- Sjogren's Syndrome --- Sjogren Syndrome --- Sicca Syndrome --- Sjogrens Syndrome --- Syndrome, Sicca --- Syndrome, Sjogren's --- Gougerot-Sjogren's syndrome --- Sicca syndrome --- Keratoconjunctivitis sicca --- Rheumatoid arthritis --- Salivary glands --- Diseases

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Cerebellar ataxia --- Paralysis, Spastic --- Hereditary Sensory and Motor Neuropathy --- Ataxia --- Heredodegenerative Disorders, Nervous System --- Cerebellar Diseases --- Spinal Cord Diseases --- Neurodegenerative Diseases --- Polyneuropathies --- Central Nervous System Diseases --- Brain Diseases --- Genetic Diseases, Inborn --- Nervous System Malformations --- Dyskinesias --- Peripheral Nervous System Diseases --- Neurologic Manifestations --- Nervous System Diseases --- Congenital Abnormalities --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Diseases --- Signs and Symptoms --- Neuromuscular Diseases --- Pathological Conditions, Signs and Symptoms --- Cerebellar Ataxia --- Spastic Paraplegia, Hereditary --- Spinocerebellar Degenerations --- Medicine --- Health & Biological Sciences --- Neurology --- Early Onset Cerebellar Ataxia --- Familial Spinocerebellar Degenerations --- Garland-Moorhouse Syndrome --- Hereditary Oligophrenic Cerebello-Lental Degeneration --- Hereditary Spinocerebellar Degenerations --- Inherited Spinocerebellar Degenerations --- Late Onset Cerebellar Ataxia --- Marie's Cerebellar Ataxia --- Marinesco-Garland Syndrome --- Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism --- Marinesco-Sjogren Syndrome-Myopathy --- Marinesco-Sjogren-Garland Syndrome --- Marinesco-Sjögren Syndrome --- Spino Cerebellar Degenerations --- Spino-Cerebellar Degenerations --- Spinocerebellar Diseases --- Ataxias, Hereditary --- Cerebellar Ataxia, Early Onset --- Cerebellar Ataxia, Late Onset --- Cerebellar Degenerations, Primary --- Corticostriatal-Spinal Degeneration --- Marie Cerebellar Ataxia --- Marinesco-Sjogren Syndrome --- Spinocerebellar Degeneration --- Ataxia, Hereditary --- Cerebellar Ataxia, Marie --- Cerebellar Ataxia, Marie's --- Cerebellar Degeneration, Primary --- Corticostriatal Spinal Degeneration --- Corticostriatal-Spinal Degenerations --- Degeneration, Corticostriatal-Spinal --- Degeneration, Familial Spinocerebellar --- Degeneration, Hereditary Spinocerebellar --- Degeneration, Inherited Spinocerebellar --- Degeneration, Primary Cerebellar --- Degeneration, Spino Cerebellar --- Degeneration, Spino-Cerebellar --- Degeneration, Spinocerebellar --- Degenerations, Corticostriatal-Spinal --- Degenerations, Familial Spinocerebellar --- Degenerations, Hereditary Spinocerebellar --- Degenerations, Inherited Spinocerebellar --- Degenerations, Primary Cerebellar --- Degenerations, Spino Cerebellar --- Degenerations, Spinocerebellar --- Familial Spinocerebellar Degeneration --- Garland Moorhouse Syndrome --- Hereditary Ataxia --- Hereditary Ataxias --- Hereditary Oligophrenic Cerebello Lental Degeneration --- Hereditary Spinocerebellar Degeneration --- Hypogonadism, Marinesco-Sjogren Syndrome-Hypergonadotrophic --- Inherited Spinocerebellar Degeneration --- Marinesco Garland Syndrome --- Marinesco Sjogren Garland Syndrome --- Marinesco Sjogren Syndrome --- Marinesco Sjogren Syndrome Hypergonadotrophic Hypogonadism --- Marinesco Sjogren Syndrome Myopathy --- Marinesco Sjögren Syndrome --- Primary Cerebellar Degeneration --- Primary Cerebellar Degenerations --- Spino Cerebellar Degeneration --- Spino-Cerebellar Degeneration --- Spinocerebellar Degeneration, Familial --- Spinocerebellar Degeneration, Hereditary --- Spinocerebellar Degeneration, Inherited --- Spinocerebellar Degenerations, Familial --- Spinocerebellar Degenerations, Hereditary --- Spinocerebellar Degenerations, Inherited --- Spinocerebellar Disease --- Syndrome, Garland-Moorhouse --- Syndrome, Marinesco-Garland --- Syndrome, Marinesco-Sjogren --- Syndrome, Marinesco-Sjogren-Garland --- Syndrome, Marinesco-Sjögren --- Syndrome-Hypergonadotrophic Hypogonadism, Marinesco-Sjogren --- Syndrome-Myopathy, Marinesco-Sjogren --- Autosomal Dominant Hereditary Spastic Paraplegia --- Autosomal Dominant Spastic Paraplegia Hereditary --- Autosomal Recessive Hereditary Spastic Paraplegia --- Autosomal Recessive Spastic Paraplegia, Hereditary --- CMT with Pyramidal Features --- Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant --- HMSN 5 --- HMSN Type V --- HMSN V --- HMSN V (Hereditary Motor and Sensory Neuropathy Type V) --- Hereditary Autosomal Dominant Spastic Paraplegia --- Hereditary Autosomal Recessive Spastic Paraplegia --- Hereditary Motor And Sensory Neuropathy V --- Hereditary Motor and Sensory Neuropathy 5 --- Hereditary Motor-Sensory Neuropathy with Pyramidal Signs --- Hereditary Spastic Paraplegia, Autosomal Recessive --- Hereditary X-Linked Recessive Spastic Paraplegia --- Hereditary, Spastic Paraplegia, Autosomal Dominant --- Hereditary, Spastic Paraplegia, X-Linked Recessive --- Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia --- Paraplegia, Spastic, Hereditary --- Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant --- Spastic Paraplegia 2 --- Spastic Paraplegia Type 2 --- Spastic Paraplegia, Autosomal Dominant, Hereditary --- Spastic Paraplegia, Autosomal Recessive, Hereditary --- Spastic Paraplegia, Hereditary, Autosomal Dominant --- Spastic Paraplegia, Hereditary, Autosomal Recessive --- Spastic Paraplegia, Hereditary, X-Linked Recessive --- Spastic Paraplegia, X-Linked Recessive, Hereditary --- Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy --- Type V Hereditary Motor and Sensory Neuropathy --- X Linked Recessive Hereditary Spastic Paraplegia --- X-linked Recessive Hereditary Spastic Paraplegia --- Hereditary Spastic Paraplegia --- X-Linked, Spastic Paraplegia, Hereditary --- Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant --- Hereditary Motor Sensory Neuropathy with Pyramidal Signs --- Hereditary Spastic Paraplegias --- Hereditary X Linked Recessive Spastic Paraplegia --- Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia --- Paraplegia, Hereditary Spastic --- Paraplegias, Hereditary Spastic --- Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy --- Spastic Paraplegias, Hereditary --- Type V, HMSN --- Cerebellar Hemiataxia --- Cerebellar Incoordination --- Hypermetria --- Adiadochokinesis --- Ataxia, Cerebellar --- Cerebellar Dysmetria --- Dysmetria --- Adiadochokineses --- Ataxias, Cerebellar --- Cerebellar Ataxias --- Cerebellar Dysmetrias --- Cerebellar Hemiataxias --- Cerebellar Incoordinations --- Dysmetria, Cerebellar --- Dysmetrias --- Dysmetrias, Cerebellar --- Hemiataxia, Cerebellar --- Hemiataxias, Cerebellar --- Hypermetrias --- Incoordination, Cerebellar --- Incoordinations, Cerebellar --- Symptoms and General Pathology --- Cramp-Fasciculation Syndrome --- Fasciculation-Cramp Syndrome, Benign --- Foley-Denny-Brown Syndrome --- Oppenheim's Disease --- Amyotonia Congenita --- Oppenheim Disease --- Benign Fasciculation-Cramp Syndrome --- Benign Fasciculation-Cramp Syndromes --- Cramp Fasciculation Syndrome --- Cramp-Fasciculation Syndromes --- Fasciculation Cramp Syndrome, Benign --- Fasciculation-Cramp Syndromes, Benign --- Foley Denny Brown Syndrome --- Neuromuscular Disease --- Oppenheims Disease --- Syndrome, Cramp-Fasciculation --- Syndrome, Foley-Denny-Brown --- Syndromes, Cramp-Fasciculation --- Symptoms and Signs --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Abnormalities, Congenital --- Defects, Congenital --- Birth Defects --- Congenital Defects --- Deformities --- Abnormality, Congenital --- Birth Defect --- Congenital Abnormality --- Congenital Defect --- Defect, Birth --- Defect, Congenital --- Defects, Birth --- Deformity --- Fetal Diseases --- Infant, Newborn, Diseases --- Teratogenesis --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Nervous System --- PNS (Peripheral Nervous System) Diseases --- PNS Diseases --- Peripheral Nervous System Disease --- Peripheral Nervous System Disorders --- Peripheral Nerve Diseases --- Peripheral Neuropathies --- Nerve Disease, Peripheral --- Nerve Diseases, Peripheral --- Neuropathy, Peripheral --- PNS Disease --- Peripheral Nerve Disease --- Peripheral Neuropathy --- Abnormal Movements --- Hemiballism --- Linguofacial Dyskinesia --- Oral Dyskinesia --- Oral-Facial Dyskinesia --- Tardive Oral Dyskinesia --- Asterixis --- Ballismus --- Hemiballismus --- Involuntary Movements --- Lingual-Facial-Buccal Dyskinesia --- Orofacial Dyskinesia --- Abnormal Movement --- Dyskinesia --- Dyskinesia, Lingual-Facial-Buccal --- Dyskinesia, Linguofacial --- Dyskinesia, Oral --- Dyskinesia, Oral-Facial --- Dyskinesia, Orofacial --- Dyskinesias, Lingual-Facial-Buccal --- Dyskinesias, Linguofacial --- Dyskinesias, Oral --- Dyskinesias, Oral-Facial --- Dyskinesias, Orofacial --- Involuntary Movement --- Lingual Facial Buccal Dyskinesia --- Lingual-Facial-Buccal Dyskinesias --- Linguofacial Dyskinesias --- Movement, Abnormal --- Movement, Involuntary --- Movements, Abnormal --- Movements, Involuntary --- Oral Dyskinesias --- Oral Facial Dyskinesia --- Oral-Facial Dyskinesias --- Orofacial Dyskinesias --- Tardive Oral Dyskinesias --- Movement Disorders --- Abnormalities, Congenital, Nervous System --- Abnormalities, Nervous System --- Anomalies, Nervous System --- Congenital Abnormalities, Nervous System --- Congenital Anomalies, Nervous System --- Congenital Malformations, Nervous System --- Cranioschisis --- Malformations, Nervous System, Congenital --- Nervous System Anomalies --- Nervous System Congenital Abnormalities --- Nervous System Congenital Malformations --- Nervous System Malformations, Congenital --- Nervous System Abnormalities --- Abnormality, Nervous System --- Anomaly, Nervous System --- Cranioschises --- Malformation, Nervous System --- Malformations, Nervous System --- Nervous System Abnormality --- Nervous System Anomaly --- Nervous System Malformation --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Genetics, Medical --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- CNS Diseases --- Central Nervous System Disorders --- CNS Disease --- Polyneuropathy, Critical Illness --- Polyneuropathy, Familial --- Polyneuropathy, Inherited --- Polyneuropathy, Motor --- Polyneuropathy, Acquired --- Acquired Polyneuropathies --- Acquired Polyneuropathy --- Critical Illness Polyneuropathies --- Critical Illness Polyneuropathy --- Familial Polyneuropathies --- Familial Polyneuropathy --- Inherited Polyneuropathies --- Inherited Polyneuropathy --- Motor Polyneuropathies --- Motor Polyneuropathy --- Polyneuropathies, Acquired --- Polyneuropathies, Critical Illness --- Polyneuropathies, Familial --- Polyneuropathies, Inherited --- Polyneuropathies, Motor --- Polyneuropathy --- Degenerative Diseases, Central Nervous System --- Degenerative Diseases, Neurologic --- Degenerative Diseases, Spinal Cord --- Degenerative Neurologic Diseases --- Degenerative Neurologic Disorders --- Nervous System Degenerative Diseases --- Neurodegenerative Disorders --- Neurologic Degenerative Conditions --- Neurologic Degenerative Diseases --- Neurologic Diseases, Degenerative --- Degenerative Diseases, Nervous System --- Degenerative Condition, Neurologic --- Degenerative Conditions, Neurologic --- Degenerative Neurologic Disease --- Degenerative Neurologic Disorder --- Neurodegenerative Disease --- Neurodegenerative Disorder --- Neurologic Degenerative Condition --- Neurologic Degenerative Disease --- Neurologic Disease, Degenerative --- Neurologic Disorder, Degenerative --- Neurologic Disorders, Degenerative --- Spinal Cord Disorders --- Myelopathy --- Myelopathies --- Spinal Cord Disease --- Spinal Cord Disorder --- Cerebellar Disorders --- Cerebellar Syndromes --- Cerebellar Dysfunction --- Cerebellum Diseases --- Cerebellar Disease --- Cerebellar Disorder --- Cerebellar Dysfunctions --- Cerebellar Syndrome --- Cerebellum Disease --- Disease, Cerebellar --- Disease, Cerebellum --- Disorder, Cerebellar --- Dysfunction, Cerebellar --- Syndrome, Cerebellar --- Degenerative Hereditary Diseases, Nervous System --- Hereditary Neurodegenerative Diseases --- Hereditary-Degenerative Disorders, Nervous System --- Nervous System Degenerative Hereditary Diseases --- Nervous System Hereditary Degenerative Diseases --- Degenerative Disease, Nervous System, Hereditary --- Degenerative Hereditary Disorders, Nervous System --- Hereditary Diseases, Neurodegenerative --- Nervous System Diseases, Degenerative, Hereditary --- Neurodegenerative Diseases, Hereditary --- Disease, Hereditary Neurodegenerative --- Disease, Neurodegenerative Hereditary --- Diseases, Hereditary Neurodegenerative --- Diseases, Neurodegenerative Hereditary --- Hereditary Degenerative Disorders, Nervous System --- Hereditary Disease, Neurodegenerative --- Hereditary Neurodegenerative Disease --- Neurodegenerative Disease, Hereditary --- Neurodegenerative Hereditary Disease --- Neurodegenerative Hereditary Diseases --- Ataxia, Appendicular --- Ataxia, Limb --- Ataxia, Motor --- Ataxia, Sensory --- Ataxia, Truncal --- Ataxy --- Dyscoordination --- Lack of Coordination --- Tremor, Rubral --- Coordination Impairment --- Dyssynergia --- Incoordination --- Appendicular Ataxia --- Appendicular Ataxias --- Ataxias --- Ataxias, Appendicular --- Ataxias, Limb --- Ataxias, Motor --- Ataxias, Sensory --- Ataxias, Truncal --- Coordination Impairments --- Coordination Lack --- Impairment, Coordination --- Impairments, Coordination --- Incoordinations --- Limb Ataxia --- Limb Ataxias --- Motor Ataxia --- Motor Ataxias --- Rubral Tremor --- Rubral Tremors --- Sensory Ataxia --- Sensory Ataxias --- Tremors, Rubral --- Truncal Ataxia --- Truncal Ataxias --- CMT4f --- Charcot-Marie-Tooth Disease, Demyelinating, Type 4f --- Charcot-Marie-Tooth Disease, Type 3 --- Dejerine-Sottas Neuropathy --- Dejerine-Sottas Syndrome --- HMSN3 --- Herditary Sensory and Motor Neuropathy --- Hereditary Motor and Sensory Neuropathy --- Hereditary Motor and Sensory Neuropathy 3 --- Hereditary Motor and Sensory Neuropathy Type III --- Hypertrophic Neuropathy of Dejerine-Sottas --- Dejerine-Sottas Disease --- HMSN --- HMSN Type III --- HMSN Type VII --- Hereditary Motor and Sensory Neuropathies --- Hereditary, Type III, Motor and Sensory Neuropathy --- Hereditary, Type VII, Motor and Sensory Neuropathy --- Neuropathies, Hereditary Motor and Sensory --- Charcot Marie Tooth Disease, Type 3 --- Dejerine Sottas Disease --- Dejerine Sottas Neuropathy --- Dejerine Sottas Syndrome --- Dejerine-Sottas Hypertrophic Neuropathy --- Disease, Dejerine-Sottas --- HMSN Type IIIs --- HMSN Type VIIs --- Hypertrophic Neuropathy of Dejerine Sottas --- Neuropathy, Dejerine-Sottas --- Syndrome, Dejerine-Sottas --- Type VII, HMSN --- Spastic paralysis --- Neuromuscular diseases --- Spasticity --- Cerebellum --- abnormalities --- Fetal Anomalies --- Fetal Malformations --- Anomaly, Fetal --- Fetal Anomaly --- Fetal Malformation --- Malformation, Fetal --- Central Nervous System Disease --- Central Nervous System Disorder