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This book presents a comprehensive overview of sickle cell anemia, with chapters addressing diagnosis and clinical, psychosocial, and pharmacological management of patients with this disease. It is a vital resource for biomedical science and medical students, interns, pediatricians, general physicians, and other healthcare professionals involved in offering care and support to patients with sickle cell disease.

Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia

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Sickle cell anemia. --- Hemolytic anemia. --- Anemia --- Hemolysis and hemolysins --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia

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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.

glucose-6-phosphate dehydrogenase --- hydroxyurea/hydroxycarbamide --- n/a --- cord blood --- screening --- hemoglobin pattern --- capillary electrophoresis --- sickle cell disease --- (recommended) screening panel --- vaso-occlusive crisis --- Guthrie spots --- newborn screening) --- foetal haemoglobin --- harmonisation --- review --- birth prevalence --- G6PD deficiency --- prevention --- end-organ damage --- thalassemia --- MALDI-TOF --- IEF --- acute chest syndrome --- India --- sickle cell and thalassaemia screening programme --- ‘Getting to Outcomes’ --- newborn screening --- hemoglobinopathy --- service users --- public health engagement --- automated HPLC --- Kaduna State --- gene therapy for haemoglobinopathies --- ?-globin gene --- methods --- neonatal screening program --- malaria --- Plasmodium vivax --- sub-Saharan Africa --- patient organisations --- health policy --- pathophysiology --- Sickle Cell Disease --- mass spectrometry --- sickle cell disorder --- neonatal screening --- non-tribal --- Nigeria --- point-of-care --- HPLC --- laboratory methods --- registry --- patient advocacy --- bone marrow transplant --- anaemia --- hemoglobinopathies --- tribal --- newborn --- burden of disease --- patient representatives --- diagnostics --- policy making --- haemolysis --- Caribbean --- high performance liquid chromatography (HPLC) --- sickle cell disease (SCD) --- implementation science --- 'Getting to Outcomes'

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Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

Pathology --- Medicine --- Health & Biological Sciences --- Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Hematology. --- Internal medicine. --- Biochemistry. --- Medicine. --- Internal Medicine. --- Medical Biochemistry. --- Medicine/Public Health, general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medicine, Internal --- Haematology --- Internal medicine --- Blood --- Composition --- Diseases --- Health Workforce --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry

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The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary ‘bioeconomies’; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs – and is shaped by – developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Presenting cutting edge research from leading social science scholars, the Handbook provides a unique and important contribution to the field. It brings a rich and varied cross disciplinary social science perspective that engages with both the history and contemporary context of genomics and ‘post-genomics’, and considers the now global and transnational terrain in which these developments are unfolding.

Sociology --- Social policy --- Genetics --- Social medicine --- E-books --- Medical care --- Medical sociology --- Medicine --- Medicine, Social --- National planning --- State planning --- Social theory --- Social aspects --- Public health --- Public welfare --- Medical ethics --- Medical sociologists --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Economic policy --- Family policy --- Social history --- Social sciences --- Society & social sciences --- Medical genetics --- Genomics --- Genome research --- Genomes --- Molecular genetics --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Research --- Genetic aspects --- genomics --- developing economies --- Africa --- Brazil --- Haplotype --- Senegal --- Sickle cell disease --- Genomics. --- Genetics, Medical. --- Genetic Testing. --- Bioethical Issues. --- Génomique --- Génétique médicale --- Société. --- Medical genetics.