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Sickle cell anemia --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Treatment.
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This book presents a comprehensive overview of sickle cell anemia, with chapters addressing diagnosis and clinical, psychosocial, and pharmacological management of patients with this disease. It is a vital resource for biomedical science and medical students, interns, pediatricians, general physicians, and other healthcare professionals involved in offering care and support to patients with sickle cell disease.
Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia
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This book addresses a wide range of clinically relevant topics and issues in sickle cell disease. This is written by experts in their own field offering a robust, engaging discussion about the presentations and mechanisms of actions in the multiple complications associated with sickle cell disease. This first of the series addresses pain, which is considered the hallmark of sickle cell presentation. It looks at the basic mechanism of pain in sickle cell disease. A more detailed review of precision medicine gives a clear well laid out presentation that is incisive and yet gives in-depth detail relevant to both the clinician and the researcher in the basic laboratory. The same pattern is shown in the discussion on respiratory, cardiac and neurological complications. The 14 chapters also include an overview of sickle cell disease especially in the paediatric age. The content is organized into well-designed broad sections on overview regarding diagnosis including point of care and the role of digital apps in patient management. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in sickle cell disease. The readership would find that it provides a well-described, concise and immediate applicable answers to complex questions. This is highly recommended for scientists and clinicians alike.
Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Medicine --- Hematology --- Hematopathology --- Health Sciences
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Sickle cell anemia. --- Hemolytic anemia. --- Anemia --- Hemolysis and hemolysins --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia
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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts. .
Medicine. --- Hematology. --- Medicine & Public Health. --- Haematology --- Clinical sciences --- Medical profession --- Sickle cell anemia --- Hematopoietic stem cells --- Treatment. --- Transplantation. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Internal medicine --- Blood --- Diseases
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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
glucose-6-phosphate dehydrogenase --- hydroxyurea/hydroxycarbamide --- n/a --- cord blood --- screening --- hemoglobin pattern --- capillary electrophoresis --- sickle cell disease --- (recommended) screening panel --- vaso-occlusive crisis --- Guthrie spots --- newborn screening) --- foetal haemoglobin --- harmonisation --- review --- birth prevalence --- G6PD deficiency --- prevention --- end-organ damage --- thalassemia --- MALDI-TOF --- IEF --- acute chest syndrome --- India --- sickle cell and thalassaemia screening programme --- ‘Getting to Outcomes’ --- newborn screening --- hemoglobinopathy --- service users --- public health engagement --- automated HPLC --- Kaduna State --- gene therapy for haemoglobinopathies --- ?-globin gene --- methods --- neonatal screening program --- malaria --- Plasmodium vivax --- sub-Saharan Africa --- patient organisations --- health policy --- pathophysiology --- Sickle Cell Disease --- mass spectrometry --- sickle cell disorder --- neonatal screening --- non-tribal --- Nigeria --- point-of-care --- HPLC --- laboratory methods --- registry --- patient advocacy --- bone marrow transplant --- anaemia --- hemoglobinopathies --- tribal --- newborn --- burden of disease --- patient representatives --- diagnostics --- policy making --- haemolysis --- Caribbean --- high performance liquid chromatography (HPLC) --- sickle cell disease (SCD) --- implementation science --- 'Getting to Outcomes'
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This practical clinical handbook reveals that sickle cell disease (SCD) is an increasingly common condition to manage in Europe and North America. SCD demands clinical expertise and experience as well as sensitivity to its social and cultural context. This book is designed to broaden readers’ knowledge in this challenging condition by describing the acute and long-term complications unique to SCD and that affect nearly every system of the body. Critically, it also details the significant recent advances in understanding the pathophysiology of SCD that are leading to novel treatment modalities. Sickle Cell Disease in Clinical Practice promotes higher quality care by outlining the clinical problems as they arise, and covering essential background information, including up-to-date research, and useful points to guide management. As such, the intended target audience is broad and includes general physicians, general practitioners, hematologists, pediatricians, emergency medicine physicians, surgeons, medical students, nurse specialists and commissioners.
Medicine & Public Health. --- Hematology. --- Pathology. --- Blood Transfusion Medicine. --- Medicine. --- Blood transfusion. --- Médecine --- Hématologie --- Pathologie --- Medicine --- Health & Biological Sciences --- Pathology --- Sickle cell anemia. --- Clinical medicine. --- Medicine, Clinical --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Haematology --- Internal medicine --- Blood --- Transfusion committees
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Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
Pathology --- Medicine --- Health & Biological Sciences --- Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Hematology. --- Internal medicine. --- Biochemistry. --- Medicine. --- Internal Medicine. --- Medical Biochemistry. --- Medicine/Public Health, general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medicine, Internal --- Haematology --- Internal medicine --- Blood --- Composition --- Diseases --- Health Workforce --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry
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This book is a wide-ranging guide to the diagnosis and management of the numerous medical and surgical complications that may arise in patients with sickle cell anemia. After introductory chapters on the genetics, pathophysiology, clinical features, and variants of sickle cell anemia, the complications observed in different parts of the body are addressed in a series of well-illustrated chapters. The coverage includes splenic, hepatobiliary, musculoskeletal, gastrointestinal, ophthalmological, cardio- and cerebrovascular, and renal complications, as well as acute chest syndrome, leg ulcers, hand and foot syndrome, acute appendicitis, and priapism. Treatment-oriented chapters consider perioperative management, blood transfusion therapy, hydroxyurea treatment, hematopoietic stem cell transplantation, and emerging strategies. The book is clearly written in a distinctive bullet point format for ease of reference and emphasizes especially aspects of practical significance. It will be of value for hematologists, general surgeons, internists, pediatricians, pediatric surgeons, fellows, residents, medical students, and nurses.
Anemia, Sickle Cell --- History, 20th Century --- Anemia, Hemolytic, Congenital --- History, Modern 1601 --- -Hemoglobinopathies --- Genetic Diseases, Inborn --- History --- Hematologic Diseases --- Anemia, Hemolytic --- Anemia --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Hemic and Lymphatic Diseases --- Humanities --- Diseases --- Pathology --- Medicine --- Health & Biological Sciences --- Sickle cell anemia --- Complications. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Hematology. --- Surgery. --- Biochemistry. --- Pediatric Surgery. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Surgery, Primitive --- Haematology --- Internal medicine --- Blood --- Composition --- Pediatric surgery. --- Medical biochemistry. --- Pediatric surgery --- Surgery, Pediatric --- Children --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Treatment
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"The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary bioeconomies; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs and is shaped by developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Presenting cutting edge research from leading social science scholars, the Handbook provides a unique and important contribution to the field. It brings a rich and varied cross disciplinary social science perspective that engages with both the history and contemporary context of genomics and post-genomics, and considers the now global and transnational terrain in which these developments are unfolding."--Provided by publisher.
Sociology --- Social policy --- Genetics --- Social medicine --- E-books --- Medical care --- Medical sociology --- Medicine --- Medicine, Social --- National planning --- State planning --- Social theory --- Social aspects --- Public health --- Public welfare --- Medical ethics --- Medical sociologists --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Economic policy --- Family policy --- Social history --- Social sciences --- Society & social sciences --- Medical genetics --- Genomics --- Genome research --- Genomes --- Molecular genetics --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Research --- Genetic aspects --- genomics --- developing economies --- Africa --- Brazil --- Haplotype --- Senegal --- Sickle cell disease --- Genomics. --- Genetics, Medical. --- Genetic Testing. --- Bioethical Issues. --- Génomique --- Génétique médicale --- Société. --- Medical genetics.
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