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Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

Enzymology --- Pharmacosynthesis. Pharmacochemistry --- CD26 antigen --- Aminopeptidases --- Congresses. --- Aminopeptidases -- Congresses. --- CD26 antigen -- Congresses. --- Antigens, Differentiation, T-Lymphocyte --- Antigens, CD --- Serine Proteases --- Exopeptidases --- Antigens, Differentiation --- Peptide Hydrolases --- Biological Markers --- Hydrolases --- Antigens, Surface --- Antigens --- Biological Factors --- Enzymes --- Chemicals and Drugs --- Enzymes and Coenzymes --- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases --- Dipeptidyl Peptidase 4 --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Immunology. --- Pharmacy. --- Internal medicine. --- Biochemistry. --- Internal Medicine. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Medicine, Internal --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Immunobiology --- Life sciences --- Serology --- Composition --- Dipeptidyl Peptidase 4. --- metabolism.

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As Editor-in-Chief of the journal Diabetology, I am pleased to announce the Special Issue “Diabetology: Feature Papers 2021” is now published in book format. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aim to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This book covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.

carpal tunnel syndrome --- ultrasound --- power doppler signal --- diabetes --- FINDRISC --- prediabetes --- metabolic syndrome --- young-adults --- N-acetyl-β-d-glucosaminidase (NAG) --- diabetic nephropathy --- chronic kidney disease (CKD) --- meta-analysis --- systematic review --- focus groups --- self-management of type 2 diabetes --- patients’ experiences --- healthcare professionals --- middle-aged population --- type 1 diabetes --- autoimmune diseases --- pancreatic β-cells --- tolerance --- regulatory T cells --- immunotherapy --- insulin --- banting --- best --- MacLeod --- collip --- limited-resource countries (LRC) --- insulin pumps --- blood glucose monitoring --- continuous blood glucose sensors --- COVID-19 --- SARS-CoV-2 --- ACE2 --- TMPRSS2 --- mucormycosis --- COVID-associated mucormycosis (CAM) --- mucins --- Diabetic Keto Acidosis (DKA) --- Metabolic-Stress-Associated Interactome (MSAI) --- olfactory neurovascular niche --- serine proteases --- ferroptosis --- redox-iron stress --- n/a --- patients' experiences

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Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases.In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Medicine --- Oncology --- colorectal cancer --- advanced adenoma --- screening --- stool --- mRNA --- cancer screening --- cirrhosis --- AFP --- machine learning --- MALDI-TOF --- proteomics --- CXCR4 --- prognosis --- overall survival --- rectal cancer --- neoadjuvant chemoradiation --- mouse model --- biomarkers --- urokinase plasminogen activator (uPA) --- urokinase plasminogen activator receptor (uPAR) --- plasminogen activator inhibitor type 1 (PAI-1) --- circulating tumour cell (CTC) --- gastric cancer --- oesophageal cancer --- serine proteases --- tumour microenvironment --- serpins --- biomarker --- chemoresistance --- liquid biopsy --- microRNA --- long non-coding RNA --- colorectal neoplasms --- cancer screening tests --- early detection of cancer --- precision medicine --- unfolded protein --- hepatocellular cancer --- GSVA --- unfolded protein score --- epigenetic regulation genes --- somatic mutations --- molecular genetic markers --- extracellular vesicles --- microbiome --- 16S rRNA amplicon --- metagenomics --- liver fibrosis --- hepatocellular carcinoma --- recurrence --- SHG/TPEF microscopy --- artificial intelligence --- advanced gastric cancer --- targeted therapy --- urinary miRNA --- miR-129-1-3p --- miR-566 --- colorectal cancer --- advanced adenoma --- screening --- stool --- mRNA --- cancer screening --- cirrhosis --- AFP --- machine learning --- MALDI-TOF --- proteomics --- CXCR4 --- prognosis --- overall survival --- rectal cancer --- neoadjuvant chemoradiation --- mouse model --- biomarkers --- urokinase plasminogen activator (uPA) --- urokinase plasminogen activator receptor (uPAR) --- plasminogen activator inhibitor type 1 (PAI-1) --- circulating tumour cell (CTC) --- gastric cancer --- oesophageal cancer --- serine proteases --- tumour microenvironment --- serpins --- biomarker --- chemoresistance --- liquid biopsy --- microRNA --- long non-coding RNA --- colorectal neoplasms --- cancer screening tests --- early detection of cancer --- precision medicine --- unfolded protein --- hepatocellular cancer --- GSVA --- unfolded protein score --- epigenetic regulation genes --- somatic mutations --- molecular genetic markers --- extracellular vesicles --- microbiome --- 16S rRNA amplicon --- metagenomics --- liver fibrosis --- hepatocellular carcinoma --- recurrence --- SHG/TPEF microscopy --- artificial intelligence --- advanced gastric cancer --- targeted therapy --- urinary miRNA --- miR-129-1-3p --- miR-566

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Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases.In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Medicine --- Oncology --- colorectal cancer --- advanced adenoma --- screening --- stool --- mRNA --- n/a --- cancer screening --- cirrhosis --- AFP --- machine learning --- MALDI-TOF --- proteomics --- CXCR4 --- prognosis --- overall survival --- rectal cancer --- neoadjuvant chemoradiation --- mouse model --- biomarkers --- urokinase plasminogen activator (uPA) --- urokinase plasminogen activator receptor (uPAR) --- plasminogen activator inhibitor type 1 (PAI-1) --- circulating tumour cell (CTC) --- gastric cancer --- oesophageal cancer --- serine proteases --- tumour microenvironment --- serpins --- biomarker --- chemoresistance --- liquid biopsy --- microRNA --- long non-coding RNA --- colorectal neoplasms --- cancer screening tests --- early detection of cancer --- precision medicine --- unfolded protein --- hepatocellular cancer --- GSVA --- unfolded protein score --- epigenetic regulation genes --- somatic mutations --- molecular genetic markers --- extracellular vesicles --- microbiome --- 16S rRNA amplicon --- metagenomics --- liver fibrosis --- hepatocellular carcinoma --- recurrence --- SHG/TPEF microscopy --- artificial intelligence --- advanced gastric cancer --- targeted therapy --- urinary miRNA --- miR-129-1-3p --- miR-566

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Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.

Research & information: general --- Biology, life sciences --- Aeromonas hydrophila --- LysR-family --- ΔlahS --- global regulator --- virulence --- Sclerotinia sclerotiorum --- SsNsd1 --- compound appressorium --- two-dimensional electrophoresis --- proteomics analysis --- differential expression proteins --- cystic fibrosis --- Pseudomonas aeruginosa --- Burkholderia cepacia complex --- small noncoding regulatory RNAs --- pathogenicity --- usg --- truA --- Salmonella enterica serovar Typhimurium --- oxidative stress --- intracellular survival --- pathogenomics --- coagulase-negative staphylococci --- virulence factors --- whole genome sequencing --- autotransporter --- covalent labeling --- bacterial surface protein --- SpyCatcher --- topology mapping --- virulence factor --- Candida --- host-pathogen interaction --- biofilm formation --- morphology --- immune evasion --- Trueperella pyogenes --- pyolysin --- infection --- immune response --- Actinomycetales --- Bordetella pertussis --- Hfq --- omics analysis --- T3SS --- serum resistance --- solute-binding proteins --- phytoplasma --- effector protein --- apple --- apple proliferation --- bacteria --- blood–brain barrier --- blood–cerebrospinal fluid barrier --- meningitis --- outer membrane vesicles (OMVs) --- Candida albicans --- antimicrobial peptides --- complement --- interspecies interactions --- inter-kingdom protection --- fungicidal activity --- fluconazole --- hyphae --- antimicrobial peptide --- EDTA --- primary ciliary dyskinesia --- anti-virulence --- sputum --- chronic infection --- Enterobacterales --- Klebsiella --- Enterobacter --- Citrobacter --- antibiotic resistance --- biofilm --- SPATEs --- UTIs --- cytotoxicity --- serine proteases --- 5637 bladder cells --- mucin --- gelatin --- actin --- protease Lon --- Dickeya solani --- plant pathogen --- motility --- type III secretion system --- resistance to stress --- lon expression --- pectinolytic enzymes --- gene expression --- manipulation --- inflammation --- persistence --- replicative niche --- actin proteolysis --- metalloproteinases --- protease ECP 32 --- grimelysin --- protealysin --- bacterial invasion --- microbial virulence factors --- bacterial pathogens --- fungal pathogens --- Aeromonas hydrophila --- LysR-family --- ΔlahS --- global regulator --- virulence --- Sclerotinia sclerotiorum --- SsNsd1 --- compound appressorium --- two-dimensional electrophoresis --- proteomics analysis --- differential expression proteins --- cystic fibrosis --- Pseudomonas aeruginosa --- Burkholderia cepacia complex --- small noncoding regulatory RNAs --- pathogenicity --- usg --- truA --- Salmonella enterica serovar Typhimurium --- oxidative stress --- intracellular survival --- pathogenomics --- coagulase-negative staphylococci --- virulence factors --- whole genome sequencing --- autotransporter --- covalent labeling --- bacterial surface protein --- SpyCatcher --- topology mapping --- virulence factor --- Candida --- host-pathogen interaction --- biofilm formation --- morphology --- immune evasion --- Trueperella pyogenes --- pyolysin --- infection --- immune response --- Actinomycetales --- Bordetella pertussis --- Hfq --- omics analysis --- T3SS --- serum resistance --- solute-binding proteins --- phytoplasma --- effector protein --- apple --- apple proliferation --- bacteria --- blood–brain barrier --- blood–cerebrospinal fluid barrier --- meningitis --- outer membrane vesicles (OMVs) --- Candida albicans --- antimicrobial peptides --- complement --- interspecies interactions --- inter-kingdom protection --- fungicidal activity --- fluconazole --- hyphae --- antimicrobial peptide --- EDTA --- primary ciliary dyskinesia --- anti-virulence --- sputum --- chronic infection --- Enterobacterales --- Klebsiella --- Enterobacter --- Citrobacter --- antibiotic resistance --- biofilm --- SPATEs --- UTIs --- cytotoxicity --- serine proteases --- 5637 bladder cells --- mucin --- gelatin --- actin --- protease Lon --- Dickeya solani --- plant pathogen --- motility --- type III secretion system --- resistance to stress --- lon expression --- pectinolytic enzymes --- gene expression --- manipulation --- inflammation --- persistence --- replicative niche --- actin proteolysis --- metalloproteinases --- protease ECP 32 --- grimelysin --- protealysin --- bacterial invasion --- microbial virulence factors --- bacterial pathogens --- fungal pathogens