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The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Bioinformatics. --- Computational biology. --- Sequence alignment (Bioinformatics) --- Alignment, Sequence (Bioinformatics) --- Determination, Sequence homology (Bioinformatics) --- Homology determination, Sequence (Bioinformatics) --- Sequence homology determination (Bioinformatics) --- Bio-informatics --- Biological informatics --- Genetics --- Amino acid sequence --- Nucleotide sequence --- Biology --- Bioinformatics --- Information science --- Computational biology --- Systems biology --- Technique --- Data processing

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The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.

Sequence alignment (Bioinformatics) --- Nucleotide sequence --- Molecular biology --- Methodology. --- Data processing. --- Biological models. --- Human genetics. --- Bioinformatics. --- Systems Biology. --- Human Genetics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Models, Biological --- Data processing --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Nucleic acids --- Nucleotides --- Alignment, Sequence (Bioinformatics) --- Determination, Sequence homology (Bioinformatics) --- Homology determination, Sequence (Bioinformatics) --- Sequence homology determination (Bioinformatics) --- Amino acid sequence --- Analysis --- Technique --- Systems biology. --- Bioinformatics --- Biological systems

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From basic performing of sequence alignment through a proficiency at understanding how most industry-standard alignment algorithms achieve their results, Multiple Sequence Alignment Methods describes numerous algorithms and their nuances in chapters written by the experts who developed these algorithms.  The various multiple sequence alignment algorithms presented in this handbook give a flavor of the broad range of choices available for multiple sequence alignment generation, and their diversity is a clear reflection of the complexity of the multiple sequence alignment problem and the amount of information that can be obtained from multiple sequence alignments.  Each of these chapters not only describes the algorithm it covers but also presents instructions and tips on using their implementation, as is fitting with its inclusion in the highly successful Methods in Molecular Biology series.   Authoritative and practical, Multiple Sequence Alignment Methods provides a readily available resource which will allow practitioners to experiment with different algorithms and find the particular algorithm that is of most use in their application.

Sequence alignment (Bioinformatics) --- Computational biology --- Publication Formats --- Genetic Techniques --- Biology --- Databases, Genetic --- Investigative Techniques --- Databases, Factual --- Biological Science Disciplines --- Publication Characteristics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Databases as Topic --- Natural Science Disciplines --- Information Systems --- Disciplines and Occupations --- Information Storage and Retrieval --- Medical Informatics Applications --- Information Science --- Medical Informatics --- Sequence Alignment --- Databases, Protein --- Methods --- Computational Biology --- Handbooks --- Health & Biological Sciences --- Biology - General --- Computational biology. --- methods --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Protein Structure Databases --- SwissProt --- Amino Acid Sequence Databases --- Databases, 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Information Technology, Health --- Medical Computer Sciences --- Medical Information Sciences --- Science, Medical Computer --- Technologies, Health Information --- Technology, Health Information --- Information Sciences --- Science, Information --- Sciences, Information --- Application, Medical Informatics --- Applications, Medical Informatics --- Informatics Applications, Medical --- Informatics Application, Medical --- Medical Informatics Application --- Data Files --- Data Linkage --- Data Retrieval --- Data Sources --- Data Storage --- Data Storage and Retrieval --- Information Extraction --- Information Storage --- Machine-Readable Data Files --- Information Retrieval --- Data File --- Data File, Machine-Readable --- Data Files, Machine-Readable --- Data Source --- Extraction, Information --- Files, Machine-Readable Data --- Information Extractions --- Machine Readable Data Files --- Machine-Readable Data File --- Retrieval, Data --- Storage, Data --- Ancillary Information Systems --- Data Systems --- Emergency Care Information Systems --- Information Retrieval Systems --- Ancillary Information System --- Data System --- Information Retrieval System --- Information System --- Information System, Ancillary --- Information Systems, Ancillary --- System, Ancillary Information --- System, Data --- System, Information --- System, Information Retrieval --- Systems, Ancillary Information --- Systems, Data --- Systems, Information --- Systems, Information Retrieval --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Data Banks as Topic --- Data Bases as Topic --- Databanks as Topic --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Data Banks, Factual --- Data Bases, Factual --- Databanks, Factual --- Data Bank, Factual --- Data Base, Factual --- Databank, Factual --- Database, Factual --- Factual Data Bank --- Factual Data Banks --- Factual Data Base --- Factual Data Bases --- Factual Databank --- Factual Databanks --- Factual Database --- Factual Databases --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Genetic Data Banks --- Genetic Data Bases --- Genetic Databanks --- Genetic Information Databases --- Genetic Databases --- Genetic Sequence Databases --- OMIM --- Online Mendelian Inheritance In Man --- Bank, Genetic Data --- Banks, Genetic Data --- Data Bank, Genetic --- Data Banks, Genetic --- Data Base, Genetic --- Data Bases, Genetic --- Databank, Genetic --- Databanks, Genetic --- Database, Genetic --- Database, Genetic Information --- Database, Genetic Sequence --- Databases, Genetic Information --- Databases, Genetic Sequence --- Genetic Data Bank --- Genetic Data Base --- Genetic Databank --- Genetic Database --- Genetic Information Database --- Genetic Sequence Database --- Information Database, Genetic --- Information Databases, Genetic --- Sequence Database, Genetic --- Sequence Databases, Genetic --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- Alignment, Sequence (Bioinformatics) --- Determination, Sequence homology (Bioinformatics) --- Homology determination, Sequence (Bioinformatics) --- Sequence homology determination (Bioinformatics) --- Bio-Informatics --- Biology, Computational --- Computational Molecular Biology --- Bioinformatics --- Molecular Biology, Computational --- Bio Informatics --- Bio-Informatic --- Bioinformatic --- Biologies, Computational Molecular --- Biology, Computational Molecular --- Computational Molecular Biologies --- Molecular Biologies, Computational --- Life sciences. --- Bioinformatics. --- Life Sciences. --- Bio-informatics --- Biological informatics --- Information science --- Systems biology --- Biosciences --- Science --- Data processing