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Cell Aging --- Aging --- Cells --- Cellules --- physiology --- Periodicals. --- Vieillissement --- Périodiques --- physiology. --- Aging. --- Chemistry --- Health Sciences --- Life Sciences --- Biochemistry --- General and Others --- Biology --- Cellular Senescence --- Aging, Biological --- Biological Aging --- Senescence --- Cellular Aging --- Aging, Cell --- Cell Senescence --- Replicative Senescence --- Senescence, Cellular --- Senescence, Replicative --- Aging, Cellular --- Senescence, Cell --- ageing --- longevity --- lifespan --- apoptosis --- gerontology --- ageing --- Organisms --- Cytology --- Mutation Accumulation --- Cell Ageing --- Cellular Ageing --- Senescence-Associated Secretory Phenotype --- Ageing, Cell --- Ageing, Cellular --- Phenotype, Senescence-Associated Secretory --- Secretory Phenotype, Senescence-Associated --- Senescence Associated Secretory Phenotype --- Geriatrics --- gerontologie

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Cell cycle --- Cell Cycle. --- DNA Damage. --- Cell Aging. --- Cell cycle. --- Celcyclus. --- Mitotic cycle --- Nuclear cycle (Cytology) --- Cellular Aging --- Aging, Cell --- Cell Senescence --- Replicative Senescence --- Senescence, Cellular --- Senescence, Replicative --- Aging, Cellular --- Cellular Senescence --- Senescence, Cell --- Injury, DNA --- DNA Injury --- Genotoxic Stress --- Stress, Genotoxic --- DNA Damages --- DNA Injuries --- Damage, DNA --- Damages, DNA --- Genotoxic Stresses --- Injuries, DNA --- Stresses, Genotoxic --- Cell Division Cycle --- Cell Cycles --- Cell Division Cycles --- Cycle, Cell --- Cycle, Cell Division --- Cycles, Cell --- Cycles, Cell Division --- Division Cycle, Cell --- Division Cycles, Cell --- Biological rhythms --- Cell Ageing --- Cellular Ageing --- Senescence-Associated Secretory Phenotype --- Cell Aging --- Ageing, Cell --- Ageing, Cellular --- Phenotype, Senescence-Associated Secretory --- Secretory Phenotype, Senescence-Associated --- Senescence Associated Secretory Phenotype --- Aging --- Mutation --- Pyrimidine Dimers --- Comet Assay --- DNA Repair Enzymes --- Cell Cycle Proteins --- Genes, cdc --- Cellular Senescence. --- Cell Cycle --- DNA Damage --- Cytologie --- Cellules --- Life Sciences --- Biology --- Cytology, Cell Biology --- DNA damage. --- Cells --- Cytology --- Cycle cellulaire --- Cycle cellulaire. --- ADN --- Aging. --- Lésions. --- Vieillissement. --- Biochemical genetics --- Mutation (Biology) --- Organisms --- Cytology. --- Cells. --- Cell biology --- Cellular biology

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Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

Research & information: general --- Biology, life sciences --- Food & society --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte

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Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

calorie restriction diet --- body mass reduction --- insulin --- IGF-1 --- leptin --- adiponectin --- malnutrition --- heart impairment --- papillary muscle assay --- calcium transient proteins --- SERCA2a --- L-type calcium channel --- aging --- autophagy --- calorie restriction (CR) --- CR mimetic --- calorie restriction --- FoxO transcription factor --- sirtuin --- neuropeptide Y --- pleiotropy of CR genes --- senescence-associated secretory phenotype --- senoinflammation --- mimetics --- intermittent fasting --- fat mass --- insulin secretion --- pancreatic islet --- lifespan --- longevity --- fasting --- skin aging --- photoaging --- skin appendages --- caloric restriction --- fatty acid biosynthesis --- mitochondrial biogenesis --- adipocyte --- n/a

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Oxidative Stress --- Cell aging --- Oxidative stress --- Cells --- Stress oxydatif --- Cellules --- Periodicals --- Aging --- Périodiques --- Vieillissement --- Oxidative Stress. --- Cell Aging. --- Oxidative stress. --- Aging. --- Life Sciences --- Biology --- oxidative stress --- cell aging --- Cell Aging --- Oxidation-reduction reaction --- Stress (Physiology) --- Organisms --- Cytology --- Cell Ageing --- Cellular Ageing --- Cellular Aging --- Senescence-Associated Secretory Phenotype --- Aging, Cell --- Cell Senescence --- Replicative Senescence --- Senescence, Cellular --- Senescence, Replicative --- Ageing, Cell --- Ageing, Cellular --- Aging, Cellular --- Phenotype, Senescence-Associated Secretory --- Secretory Phenotype, Senescence-Associated --- Senescence Associated Secretory Phenotype --- Senescence, Cell --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Cellular Senescence --- Cellular Senescence. --- Periodicals. --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative --- Histology. Cytology