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Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.

Medicine --- conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia --- conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia

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This Special Issue of Marine Drugs gathers recent investigations on the proteomes, metabolomes, transcriptomes, and the associated microbiomes of marine jellyfish and polyps, including bioactivity studies of their compounds and more generally, on their biotechnological potential, witnessing the increasingly recognized importance of Cnidaria as a largely untapped Blue Growth resource for new drug discovery. These researches evoke the outstanding ecological importance of cnidarians in marine ecosystems worldwide, calling for a global monitoring and conservation of marine biodiversity, so that the biotechnological exploitation of marine living resources will be carried out to conserve and sustainably use the natural capital of the oceans.

Technology: general issues --- cnidarian --- sea anemone --- proteins --- toxins --- two-dimensional gel electrophoresis --- MALDI-TOF/TOF --- shotgun proteomic --- Zoanthidea --- holo-transcriptome --- cnidarian transcriptome --- marine enzyme --- marine biocatalyst --- marine biotechnology --- pharmaceutical biotechnology --- anthozoa --- microbial communities --- cnidarian holobiont --- zooxanthellae --- bleaching --- antibacterial activity --- jellyfish --- Aurelia coerulea --- mucus --- proteomics --- metabolomics --- cnidarians --- gelatinous zooplankton --- bioprospecting --- novel foods --- transcriptomics --- bio-prospecting --- computational biology --- neurotoxins --- NMR spectroscopy --- biochemical characterization --- jellyfish blooms --- Cnidaria --- Ctenophora --- biodiversity --- bioactive compounds --- blue biotechnology --- invertebrate proteins --- biological activity --- antioxidants --- collagen --- pepsin hydrolysis --- collagenase hydrolysis --- oxidative stress --- keratinocytes --- cytotoxicity --- Easter Island --- Actinobacteria --- anthraquinones --- symbionts --- marine invertebrates --- spectroscopy --- chromatography --- Pelagia noctiluca --- Mediterranean jellyfish --- chemical characterization --- aquafeed and food supplements --- sustainable fishing

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This Special Issue of Marine Drugs gathers recent investigations on the proteomes, metabolomes, transcriptomes, and the associated microbiomes of marine jellyfish and polyps, including bioactivity studies of their compounds and more generally, on their biotechnological potential, witnessing the increasingly recognized importance of Cnidaria as a largely untapped Blue Growth resource for new drug discovery. These researches evoke the outstanding ecological importance of cnidarians in marine ecosystems worldwide, calling for a global monitoring and conservation of marine biodiversity, so that the biotechnological exploitation of marine living resources will be carried out to conserve and sustainably use the natural capital of the oceans.

Technology: general issues --- cnidarian --- sea anemone --- proteins --- toxins --- two-dimensional gel electrophoresis --- MALDI-TOF/TOF --- shotgun proteomic --- Zoanthidea --- holo-transcriptome --- cnidarian transcriptome --- marine enzyme --- marine biocatalyst --- marine biotechnology --- pharmaceutical biotechnology --- anthozoa --- microbial communities --- cnidarian holobiont --- zooxanthellae --- bleaching --- antibacterial activity --- jellyfish --- Aurelia coerulea --- mucus --- proteomics --- metabolomics --- cnidarians --- gelatinous zooplankton --- bioprospecting --- novel foods --- transcriptomics --- bio-prospecting --- computational biology --- neurotoxins --- NMR spectroscopy --- biochemical characterization --- jellyfish blooms --- Cnidaria --- Ctenophora --- biodiversity --- bioactive compounds --- blue biotechnology --- invertebrate proteins --- biological activity --- antioxidants --- collagen --- pepsin hydrolysis --- collagenase hydrolysis --- oxidative stress --- keratinocytes --- cytotoxicity --- Easter Island --- Actinobacteria --- anthraquinones --- symbionts --- marine invertebrates --- spectroscopy --- chromatography --- Pelagia noctiluca --- Mediterranean jellyfish --- chemical characterization --- aquafeed and food supplements --- sustainable fishing --- cnidarian --- sea anemone --- proteins --- toxins --- two-dimensional gel electrophoresis --- MALDI-TOF/TOF --- shotgun proteomic --- Zoanthidea --- holo-transcriptome --- cnidarian transcriptome --- marine enzyme --- marine biocatalyst --- marine biotechnology --- pharmaceutical biotechnology --- anthozoa --- microbial communities --- cnidarian holobiont --- zooxanthellae --- bleaching --- antibacterial activity --- jellyfish --- Aurelia coerulea --- mucus --- proteomics --- metabolomics --- cnidarians --- gelatinous zooplankton --- bioprospecting --- novel foods --- transcriptomics --- bio-prospecting --- computational biology --- neurotoxins --- NMR spectroscopy --- biochemical characterization --- jellyfish blooms --- Cnidaria --- Ctenophora --- biodiversity --- bioactive compounds --- blue biotechnology --- invertebrate proteins --- biological activity --- antioxidants --- collagen --- pepsin hydrolysis --- collagenase hydrolysis --- oxidative stress --- keratinocytes --- cytotoxicity --- Easter Island --- Actinobacteria --- anthraquinones --- symbionts --- marine invertebrates --- spectroscopy --- chromatography --- Pelagia noctiluca --- Mediterranean jellyfish --- chemical characterization --- aquafeed and food supplements --- sustainable fishing

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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

Research & information: general --- polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC–DAD–MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity --- n/a --- HPLC-DAD-MS

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The aim of the present Special Issue is to address the state-of-art of mitochondrial genomics and phylogenomics. Mitochondrial markers are widespread in phylogenetics; however, it is becoming increasingly clear that (i) many discordance issues arise with respect to nuclear markers and (ii) many features that are normally considered 'typical' for the mitochondrial genome are indeed highly unstable and unconserved.

Acari Actinotrichida --- COI --- cytochrome B --- genetic identification --- Hydrachnidia --- Culicidae --- reverse taxonomy --- species identification --- Unio crassus --- freshwater mussels --- population genetics --- genetic diversity --- mtDNA --- ITS --- codon degeneration --- phylogenetic conflict --- deep phylogeny --- ratite --- Theileria parva --- mitogenomes --- haplotypes --- SNPs --- live vaccine --- fig wasps --- classification --- phylogeny --- mitochondrial gene --- transcriptome --- divergence --- Diptera --- saturation --- rates --- banana --- diversification times --- mitochondrial genome --- Mycosphaerellaceae --- plant pathogens --- Pseudocercospora --- sigatoka disease --- wild sheep --- bighorn --- taxonomy --- cytochrome b --- Yakut snow sheep --- Ovis nivicola lydekkeri --- Actiniaria --- group I intron --- mitogenome --- rearrangement --- sea anemone --- 2D RNA-Barcoding --- molecular morphology --- Nudibranchia --- Dondice --- heteroplasmy --- paternal leakage --- NUMTs --- selection --- mtDNA architecture --- mtDNA structure --- nucleotide composition --- compositional bias --- strand asymmetry --- Eukaryota --- mtDNA expansion --- ICZN --- homonym --- Heterobranchia --- Crassostrea angulata --- Portuguese oyster --- cox1 --- phylogeography --- phylogenetics --- haplotype diversity --- oyster conservation --- n/a