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547.12 --- Organonitrogen compounds --- Methylenimine --- Schiff bases --- Schiff's bases --- Condensation products (Chemistry) --- Nitrogen organic compounds --- Nitrogen compounds --- Organic compounds --- Carbon bonds. Arrangement of carbon atoms in the molecule --- Methylenimine. --- Organonitrogen compounds. --- Schiff bases. --- Basic Sciences. Chemistry --- Chemistry (General) --- Chemistry (General). --- 547.12 Carbon bonds. Arrangement of carbon atoms in the molecule

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This book describes unconventional noncovalent interactions and analyzes their importance for crystal growth in organic and hybrid organic–inorganic systems. Several examples illustrate how the combination of theory and experiment allows rationalizing the strength and directionality of noncovalent interactions. This book elegantly describes the results of a survey of X-ray structures of main group element compounds (M = Sn, Pb As, Sb, Bi, and Te) exhibiting intermolecular M•••Se noncovalent interactions in one of its chapters. Moreover, it provides a consistent description of noncovalent interactions, covering most groups of the periodic table. The interactions are described and discussed using their trivial names. That is, a comprehensive and accurate description is provided for alkali, alkaline earth, regium, spodium, triel, tetrel, pnictogen, chalcogen, halogen, and aerogen bonding interactions. No other book is available covering such an extensive number of interactions and examples where these interactions are relevant. relevant.

Research & information: general --- Biology, life sciences --- non-covalent interactions --- regium bonds --- silver(I) --- coinage metals --- pyrazolates --- phosphines --- halogen bonding --- hydrogen bonding sigma-hole interactions --- theoretical studies --- characterizations --- noncovalent interactions --- Lewis acids --- Lewis bases --- spodium bonds --- σ/π-hole interactions --- EDTA --- 2,6-diaminopurine --- cadmium --- co-crystal --- H-bonding --- π–π stacking --- triazinane --- 1,3,5-Triazacyclohexane --- Hirshfeld surface analysis --- DFT study --- C–H···π interaction --- hybridization of a nitrogen atom in sulfonamides --- molecular cocrystal --- sandwiched-layer structure --- C–I···F halogen bonds --- π···π stacking interactions --- PBE0-D3(BJ) calculations --- secondary bonding --- supramolecular --- crystal engineering --- tetrel bonding --- pnictogen bonding --- chalcogen bonding --- selenium --- structural chemistry --- main group elements --- π–hole interaction --- substituent effects --- vibrational spectroscopy --- local vibrational mode theory --- direct measure for π–hole interaction strength --- noncovalent interaction --- hydrogen bonding --- nickel --- Schiff bases --- crystallography --- σ-hole --- π-hole --- crystal growth --- supramolecular chemistry --- σ-hole interactions --- self-assembly --- scanning tunneling microscopy

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This book describes unconventional noncovalent interactions and analyzes their importance for crystal growth in organic and hybrid organic–inorganic systems. Several examples illustrate how the combination of theory and experiment allows rationalizing the strength and directionality of noncovalent interactions. This book elegantly describes the results of a survey of X-ray structures of main group element compounds (M = Sn, Pb As, Sb, Bi, and Te) exhibiting intermolecular M•••Se noncovalent interactions in one of its chapters. Moreover, it provides a consistent description of noncovalent interactions, covering most groups of the periodic table. The interactions are described and discussed using their trivial names. That is, a comprehensive and accurate description is provided for alkali, alkaline earth, regium, spodium, triel, tetrel, pnictogen, chalcogen, halogen, and aerogen bonding interactions. No other book is available covering such an extensive number of interactions and examples where these interactions are relevant. relevant.

non-covalent interactions --- regium bonds --- silver(I) --- coinage metals --- pyrazolates --- phosphines --- halogen bonding --- hydrogen bonding sigma-hole interactions --- theoretical studies --- characterizations --- noncovalent interactions --- Lewis acids --- Lewis bases --- spodium bonds --- σ/π-hole interactions --- EDTA --- 2,6-diaminopurine --- cadmium --- co-crystal --- H-bonding --- π–π stacking --- triazinane --- 1,3,5-Triazacyclohexane --- Hirshfeld surface analysis --- DFT study --- C–H···π interaction --- hybridization of a nitrogen atom in sulfonamides --- molecular cocrystal --- sandwiched-layer structure --- C–I···F halogen bonds --- π···π stacking interactions --- PBE0-D3(BJ) calculations --- secondary bonding --- supramolecular --- crystal engineering --- tetrel bonding --- pnictogen bonding --- chalcogen bonding --- selenium --- structural chemistry --- main group elements --- π–hole interaction --- substituent effects --- vibrational spectroscopy --- local vibrational mode theory --- direct measure for π–hole interaction strength --- noncovalent interaction --- hydrogen bonding --- nickel --- Schiff bases --- crystallography --- σ-hole --- π-hole --- crystal growth --- supramolecular chemistry --- σ-hole interactions --- self-assembly --- scanning tunneling microscopy

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This book describes unconventional noncovalent interactions and analyzes their importance for crystal growth in organic and hybrid organic–inorganic systems. Several examples illustrate how the combination of theory and experiment allows rationalizing the strength and directionality of noncovalent interactions. This book elegantly describes the results of a survey of X-ray structures of main group element compounds (M = Sn, Pb As, Sb, Bi, and Te) exhibiting intermolecular M•••Se noncovalent interactions in one of its chapters. Moreover, it provides a consistent description of noncovalent interactions, covering most groups of the periodic table. The interactions are described and discussed using their trivial names. That is, a comprehensive and accurate description is provided for alkali, alkaline earth, regium, spodium, triel, tetrel, pnictogen, chalcogen, halogen, and aerogen bonding interactions. No other book is available covering such an extensive number of interactions and examples where these interactions are relevant. relevant.

Research & information: general --- Biology, life sciences --- non-covalent interactions --- regium bonds --- silver(I) --- coinage metals --- pyrazolates --- phosphines --- halogen bonding --- hydrogen bonding sigma-hole interactions --- theoretical studies --- characterizations --- noncovalent interactions --- Lewis acids --- Lewis bases --- spodium bonds --- σ/π-hole interactions --- EDTA --- 2,6-diaminopurine --- cadmium --- co-crystal --- H-bonding --- π–π stacking --- triazinane --- 1,3,5-Triazacyclohexane --- Hirshfeld surface analysis --- DFT study --- C–H···π interaction --- hybridization of a nitrogen atom in sulfonamides --- molecular cocrystal --- sandwiched-layer structure --- C–I···F halogen bonds --- π···π stacking interactions --- PBE0-D3(BJ) calculations --- secondary bonding --- supramolecular --- crystal engineering --- tetrel bonding --- pnictogen bonding --- chalcogen bonding --- selenium --- structural chemistry --- main group elements --- π–hole interaction --- substituent effects --- vibrational spectroscopy --- local vibrational mode theory --- direct measure for π–hole interaction strength --- noncovalent interaction --- hydrogen bonding --- nickel --- Schiff bases --- crystallography --- σ-hole --- π-hole --- crystal growth --- supramolecular chemistry --- σ-hole interactions --- self-assembly --- scanning tunneling microscopy --- non-covalent interactions --- regium bonds --- silver(I) --- coinage metals --- pyrazolates --- phosphines --- halogen bonding --- hydrogen bonding sigma-hole interactions --- theoretical studies --- characterizations --- noncovalent interactions --- Lewis acids --- Lewis bases --- spodium bonds --- σ/π-hole interactions --- EDTA --- 2,6-diaminopurine --- cadmium --- co-crystal --- H-bonding --- π–π stacking --- triazinane --- 1,3,5-Triazacyclohexane --- Hirshfeld surface analysis --- DFT study --- C–H···π interaction --- hybridization of a nitrogen atom in sulfonamides --- molecular cocrystal --- sandwiched-layer structure --- C–I···F halogen bonds --- π···π stacking interactions --- PBE0-D3(BJ) calculations --- secondary bonding --- supramolecular --- crystal engineering --- tetrel bonding --- pnictogen bonding --- chalcogen bonding --- selenium --- structural chemistry --- main group elements --- π–hole interaction --- substituent effects --- vibrational spectroscopy --- local vibrational mode theory --- direct measure for π–hole interaction strength --- noncovalent interaction --- hydrogen bonding --- nickel --- Schiff bases --- crystallography --- σ-hole --- π-hole --- crystal growth --- supramolecular chemistry --- σ-hole interactions --- self-assembly --- scanning tunneling microscopy

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The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation