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Animal biochemistry --- Ion Channels --- Saxitoxin --- Tetrodotoxin --- Sodium channels --- Neurotoxic agents --- metabolism --- Physiological effect --- Ion Channels. --- 577.352.465 --- -Saxitoxin --- -Sodium channels --- -Tetrodotoxin --- -#WPLT:dd.prof.J.Vendrig --- Fuga toxin --- Tarichatoxin --- Marine toxins --- Pyrimidines --- Channels, Sodium --- Ion channels --- Sodium --- Gonyaulax toxin --- Paralytic shellfish poison --- Algal toxins --- Purines --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Poisons --- Ion Channel --- Ionic Channel --- Ionic Channels --- Membrane Channel --- Membrane Channels --- Channel, Ion --- Channel, Ionic --- Channel, Membrane --- Channels, Ion --- Channels, Ionic --- Channels, Membrane --- Signal Transduction --- metabolism. --- Ion transport --- -Congresses --- Congresses --- Physiological transport --- ION CHANNELS --- SAXITOXIN --- TETRODOTOXIN --- Congresses. --- congresses. --- 577.352.465 Ion transport --- Metabolism --- #WPLT:dd.prof.J.Vendrig --- Physiological effect&delete& --- Ion Channels - congresses --- Saxitoxin - metabolism - Congresses --- Tetrodotoxin - metabolism - Congresses --- Tetrodotoxin - Physiological effect - Congresses --- Saxitoxin - Physiological effect - Congresses --- Sodium channels - Congresses --- Neurotoxic agents - Physiological effect - Congresses

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Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.

conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia

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The emergence of marine and freshwater toxins in geographical areas where they have never been reported before is a concern due to the considerable impact on (sea)food contamination, and consequently, on public health. Several groups of marine biotoxins, in particular tetrodotoxins, ciguatoxins, and palytoxins, are included among the relevant marine biotoxins that have recently emerged in several coastal areas. A similar situation has been observed in freshwater, where cyanobacterial toxins, such as microcystins, could end up in unexpected areas such as the estuaries where shellfish are cultivated. Climate change and the increased availability of nutrients have been considered as the key factors in the expansion of all of these toxins into new areas; however, this could also be due to more intense biological invasions, more sensitive analytical methods, or perhaps even an increased scientific interest in these natural contaminations. The incidences of human intoxications due to the consumption of seafood contaminated with these toxins have made their study an important task to accomplish in order to protect human health. This Special Issue has a focus on a wide variety of emerging biotoxin classes and techniques to identify and quantify them.

n/a --- C-CTX-1 --- non-targeted analysis --- ciguatera fish poisoning --- suspects screening --- neurodegeneration --- adaptation --- LC-HRMS --- paralytic shellfish toxins --- LC-MS/MS --- animal toxins --- identification --- method characterization --- caribbean ciguatoxins --- oral toxicity --- water flea --- quorum sensing --- eutrophication --- beta-methyl-amino-l-alanine --- dynamics simulation --- thermal water --- spent medium --- Microcystis --- Gambierdiscus --- gambierdiscus --- whole genome sequencing --- palytoxin --- conotoxin --- ovatoxins --- cyanobacterial toxin --- BMAA --- Ciguatera fish poisoning --- Rastrineobola argentea --- calcium-activated K+ ion channel --- toxicity equivalence factor --- NMR spectroscopy --- N2a --- PPIA --- marine biotoxins --- Daphnia magna --- ELISA --- disulfide-rich peptide --- food chain --- ShK-like peptide --- voltage-gated K+ ion channel --- targeted analysis --- Chinese yellow catfish --- marine --- macaronesia --- neuroblastoma bioassay --- marine toxins --- acute toxicity --- algal–bacterial relationship --- mass spectrometry --- tetrodotoxins --- saxitoxin --- toxicology --- cationization --- seafood safety --- evolution --- cyanotoxins --- toxin genes --- zoantharian --- spatial variability --- dopaminergic neurons --- tetrodotoxin --- bivalve mollusks --- algal-bacterial relationship --- Murntuluk / Catfish (Central NT, North NT SE52-03)

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At present, cyanobacteria and their toxins (also known as cyanotoxins) constitute a major threat for freshwater resources worldwide. Cyanotoxin occurrence in water bodies around the globe is constantly increasing, whereas emerging, less studied or completely new variants and congeners of various chemical classes of cyanotoxins, as well as their degradation/transformation products are often detected. In addition to planctic cyanobacteria, benthic cyanobacteria, in many cases, appear to be important toxin producers, although far less studied and more difficult to manage and control. This Special Issue highlights novel research results on the structural diversity of cyanotoxins from planktic and benthic cyanobacteria, as well as on their expanding global geographical spread in freshwaters.

Research & information: general --- Environmental economics --- Meiktila Lake --- Raphidiopsis --- Microcystis --- cylindrospermopsin --- deoxycylindrospermopsin --- microcystin --- cyanobacteria --- cyanopeptides --- harmful bloom --- liquid chromatography-tandem mass spectrometry --- global natural product social networking (GNPS) --- dereplication strategy --- earthquakes --- harmful algal blooms --- sediment --- sediment cores --- co-occurrence --- toxicity --- plastics --- metals --- biocide --- anatoxin-a --- dihydroanatoxin-a --- Tychonema --- neurotoxicosis --- cyanotoxins --- macrophytes --- benthic --- tychoplanktic --- reservoir --- Maumee Bay --- Sandusky Bay --- Planktothrix --- anatoxin --- cyanotoxin detection --- harmful cyanobacterial blooms --- next-generation biomonitoring --- real-time PCR --- qPCR --- LC-MS/MS --- saxitoxin --- ESI-LC-MS/MS --- 16S rRNA phylogeny --- Azores --- eutrophication --- long term monitoring --- water quality --- microcystins --- anabaenopeptins --- microginins --- aeruginosins --- aeruginosamide --- SPE --- Lake Vegoritis --- deep-chlorophyll layers (DCLs) --- cyanobacterial toxins --- allelopathy --- bioactive metabolites --- hypoxia --- Georgian Bay --- peptide --- NRPS --- anabaenopeptin --- Synechococcus --- temperate lakes --- cyanotoxins (CTs) --- microcystins (MCs) --- volatile organic compounds (VOCs) --- taste and odor (T&O) compounds --- SPE-LC-MS/MS --- HS-SPME-GC/MS --- LC-qTRAP MS/MS --- fragmentation spectra --- structure elucidation --- cyanobacterial metabolites --- Greek freshwaters --- planktonic cyanobacteria --- blooms --- monitoring --- analysis --- mass spectrometry --- Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) --- fish tissue --- shellfish --- detection methods --- Meiktila Lake --- Raphidiopsis --- Microcystis --- cylindrospermopsin --- deoxycylindrospermopsin --- microcystin --- cyanobacteria --- cyanopeptides --- harmful bloom --- liquid chromatography-tandem mass spectrometry --- global natural product social networking (GNPS) --- dereplication strategy --- earthquakes --- harmful algal blooms --- sediment --- sediment cores --- co-occurrence --- toxicity --- plastics --- metals --- biocide --- anatoxin-a --- dihydroanatoxin-a --- Tychonema --- neurotoxicosis --- cyanotoxins --- macrophytes --- benthic --- tychoplanktic --- reservoir --- Maumee Bay --- Sandusky Bay --- Planktothrix --- anatoxin --- cyanotoxin detection --- harmful cyanobacterial blooms --- next-generation biomonitoring --- real-time PCR --- qPCR --- LC-MS/MS --- saxitoxin --- ESI-LC-MS/MS --- 16S rRNA phylogeny --- Azores --- eutrophication --- long term monitoring --- water quality --- microcystins --- anabaenopeptins --- microginins --- aeruginosins --- aeruginosamide --- SPE --- Lake Vegoritis --- deep-chlorophyll layers (DCLs) --- cyanobacterial toxins --- allelopathy --- bioactive metabolites --- hypoxia --- Georgian Bay --- peptide --- NRPS --- anabaenopeptin --- Synechococcus --- temperate lakes --- cyanotoxins (CTs) --- microcystins (MCs) --- volatile organic compounds (VOCs) --- taste and odor (T&O) compounds --- SPE-LC-MS/MS --- HS-SPME-GC/MS --- LC-qTRAP MS/MS --- fragmentation spectra --- structure elucidation --- cyanobacterial metabolites --- Greek freshwaters --- planktonic cyanobacteria --- blooms --- monitoring --- analysis --- mass spectrometry --- Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) --- fish tissue --- shellfish --- detection methods

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At present, cyanobacteria and their toxins (also known as cyanotoxins) constitute a major threat for freshwater resources worldwide. Cyanotoxin occurrence in water bodies around the globe is constantly increasing, whereas emerging, less studied or completely new variants and congeners of various chemical classes of cyanotoxins, as well as their degradation/transformation products are often detected. In addition to planctic cyanobacteria, benthic cyanobacteria, in many cases, appear to be important toxin producers, although far less studied and more difficult to manage and control. This Special Issue highlights novel research results on the structural diversity of cyanotoxins from planktic and benthic cyanobacteria, as well as on their expanding global geographical spread in freshwaters.

Meiktila Lake --- Raphidiopsis --- Microcystis --- cylindrospermopsin --- deoxycylindrospermopsin --- microcystin --- cyanobacteria --- cyanopeptides --- harmful bloom --- liquid chromatography-tandem mass spectrometry --- global natural product social networking (GNPS) --- dereplication strategy --- earthquakes --- harmful algal blooms --- sediment --- sediment cores --- co-occurrence --- toxicity --- plastics --- metals --- biocide --- anatoxin-a --- dihydroanatoxin-a --- Tychonema --- neurotoxicosis --- cyanotoxins --- macrophytes --- benthic --- tychoplanktic --- reservoir --- Maumee Bay --- Sandusky Bay --- Planktothrix --- anatoxin --- cyanotoxin detection --- harmful cyanobacterial blooms --- next-generation biomonitoring --- real-time PCR --- qPCR --- LC-MS/MS --- saxitoxin --- ESI-LC-MS/MS --- 16S rRNA phylogeny --- Azores --- eutrophication --- long term monitoring --- water quality --- microcystins --- anabaenopeptins --- microginins --- aeruginosins --- aeruginosamide --- SPE --- Lake Vegoritis --- deep-chlorophyll layers (DCLs) --- cyanobacterial toxins --- allelopathy --- bioactive metabolites --- hypoxia --- Georgian Bay --- peptide --- NRPS --- anabaenopeptin --- Synechococcus --- temperate lakes --- cyanotoxins (CTs) --- microcystins (MCs) --- volatile organic compounds (VOCs) --- taste and odor (T&O) compounds --- SPE-LC-MS/MS --- HS-SPME-GC/MS --- LC–qTRAP MS/MS --- fragmentation spectra --- structure elucidation --- cyanobacterial metabolites --- Greek freshwaters --- planktonic cyanobacteria --- blooms --- monitoring --- analysis --- mass spectrometry --- Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) --- fish tissue --- shellfish --- detection methods --- n/a --- LC-qTRAP MS/MS