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Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, that has led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.
Poliomyelitis vaccine --- Poliomyelitis --- Vaccines --- Biologicals --- Anterior spinal paralysis --- Infantile paralysis --- Paralysis, Anterior spinal --- Paralysis, Infantile --- Polio --- Central nervous system --- Enterovirus diseases --- Myelitis --- Live poliovirus vaccine --- Salk vaccine --- History. --- Vaccination --- Infections --- Prevention --- Cutter Laboratories. --- Cutter Group --- Cutter Analytic Laboratory
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Across most of the world, an entire generation has lived free from the spectre of polio, but for fifty years during the twentieth century that fear was overwhelming. Dancing in My Dreams investigates the disease of polio and its treatment over a long period, the scientific endeavour that led to the discovery of the poliovirus, and the early studies in virology and immunology that culminated in the production of a polio vaccine. For the first time, in a history of this disease, the voice of the polio survivor can also be clearly heard.
Poliomyelitis --- Anterior spinal paralysis --- Infantile paralysis --- Paralysis, Anterior spinal --- Paralysis, Infantile --- Polio --- Central nervous system --- Enterovirus diseases --- Myelitis --- History. --- Treatment. --- Prevention. --- Vaccination. --- Infections --- Poliomyelitis vaccine --- Poliovirus --- Encephalitis, Polio --- Epidemic Acute Poliomyelitis --- Polio Encephalitis --- Poliomyelitis Infection --- Poliomyelitis, Acute --- Infantile Paralysis --- Poliomyelitis, Nonpoliovirus --- Poliomyelitis, Preparalytic --- Acute Poliomyelitis --- Acute Poliomyelitis, Epidemic --- Infection, Poliomyelitis --- Infections, Poliomyelitis --- Nonpoliovirus Poliomyelitis --- Poliomyelitides, Preparalytic --- Poliomyelitis Infections --- Poliomyelitis, Epidemic Acute --- Polios --- Preparalytic Poliomyelitis --- Postpoliomyelitis Syndrome --- Live poliovirus vaccine --- Salk vaccine --- Treatment --- Prevention --- Vaccination --- Social aspects --- Research --- History --- Australian --- Poliomyelitis virus --- Enteroviruses
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Human experimentation in medicine --- Medicine --- Poliomyelitis vaccine --- Moral and ethical aspects --- Research --- Law and legislation --- #SBIB:316.334.3M11 --- Medische sociologie: concepten en theorieën --- Ethics, Research Biomedical Research -- history. --- Ethics, Research. --- Human experimentation in medicine -- Moral and ethical aspects -- United States. --- Human experimentation in medicine - Moral and ethical aspects - United States. --- Medicine -- Research -- Law and legislation -- United States. --- Medicine - Research - Law and legislation - United States. --- Medicine -- Research -- Moral and ethical aspects -- United States. --- Medicine - Research - Moral and ethical aspects - United States. --- Poliomyelitis vaccine -- Research -- Moral and ethical aspects -- United States. --- Poliovirus Vaccines -- history. --- Government Regulation --- Research Personnel --- Autoexperimentation --- Poliovirus Vaccines --- Influenza Vaccines --- Viral Vaccines --- -Epidemiologic Measurements --- #SBIB:316.334.3M51 --- Live poliovirus vaccine --- Salk vaccine --- Poliomyelitis --- Health Workforce --- Experimentation on humans, Medical --- Medical experimentation on humans --- Medical ethics --- Medicine, Experimental --- Clinical trials --- Organisatie van de gezondheidszorg: modellen van therapeutisch handelen --- Prevention
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In 1988, the World Health Organization launched a campaign for the global eradication of polio. Today, this goal is closer than ever. Fewer than 1,300 people were paralyzed from the disease in 2004, down from approximately 350,000 in 1988. In The Death of a Disease, science writers Bernard Seytre and Mary Shaffer tell the dramatic story of this crippling virus that has evoked terror among parents and struck down healthy children for centuries. Beginning in ancient Egypt, the narrative explores the earliest stages of research, describes the wayward paths taken by a long line of scientists-each of whom made a vital contribution to understanding this enigmatic virus-and traces the development of the Salk and Sabin vaccines. The book also tracks the contemporary polio story, detailing the remaining obstacles as well as the medical, governmental, and international health efforts that are currently being focused on developing countries such as India, Pakistan, Nigeria, and Niger. At a time when emerging diseases and the threat of bioterrorism are the focus of much media and public attention, this book tells the story of a crippling disease that is on the verge of disappearing. In the face of tremendous odds, the near-eradication of polio offers an inspiring story that is both encouraging and instructive to those at the center of the continued fight against communicable diseases.
Vaccination --- History, 20th Century. --- Poliomyelitis --- Poliomyelitis vaccine --- Live poliovirus vaccine --- Salk vaccine --- Anterior spinal paralysis --- Infantile paralysis --- Paralysis, Anterior spinal --- Paralysis, Infantile --- Polio --- Central nervous system --- Enterovirus diseases --- Myelitis --- 20th Cent. History (Medicine) --- 20th Cent. History of Medicine --- 20th Cent. Medicine --- Historical Events, 20th Century --- History of Medicine, 20th Cent. --- History, Twentieth Century --- Medical History, 20th Cent. --- Medicine, 20th Cent. --- 20th Century History --- 20th Cent. Histories (Medicine) --- 20th Century Histories --- Cent. Histories, 20th (Medicine) --- Cent. History, 20th (Medicine) --- Century Histories, 20th --- Century Histories, Twentieth --- Century History, 20th --- Century History, Twentieth --- Histories, 20th Cent. (Medicine) --- Histories, 20th Century --- Histories, Twentieth Century --- History, 20th Cent. (Medicine) --- Twentieth Century Histories --- Twentieth Century History --- history. --- prevention & control. --- History. --- Prevention --- Infections
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African American universities and colleges --- Medicine --- Poliomyelitis vaccine --- History, 20th Century --- History, 19th Century --- Race Relations --- Poliovirus Vaccines --- Health Services --- Biomedical Research --- Universities --- 19th Cent. History (Medicine) --- 19th Cent. History of Medicine --- 19th Cent. Medicine --- Historical Events, 19th Century --- History of Medicine, 19th Cent. --- History, Nineteenth Century --- Medical History, 19th Cent. --- Medicine, 19th Cent. --- 19th Century History --- 19th Cent. Histories (Medicine) --- 19th Century Histories --- Cent. Histories, 19th (Medicine) --- Cent. History, 19th (Medicine) --- Century Histories, 19th --- Century Histories, Nineteenth --- Century History, 19th --- Century History, Nineteenth --- Histories, 19th Cent. (Medicine) --- Histories, 19th Century --- Histories, Nineteenth Century --- History, 19th Cent. (Medicine) --- Nineteenth Century Histories --- Nineteenth Century History --- 20th Cent. History (Medicine) --- 20th Cent. History of Medicine --- 20th Cent. Medicine --- Historical Events, 20th Century --- History of Medicine, 20th Cent. --- History, Twentieth Century --- Medical History, 20th Cent. --- Medicine, 20th Cent. --- 20th Century History --- 20th Cent. Histories (Medicine) --- 20th Century Histories --- Cent. Histories, 20th (Medicine) --- Cent. History, 20th (Medicine) --- Century Histories, 20th --- Century Histories, Twentieth --- Century History, 20th --- Century History, Twentieth --- Histories, 20th Cent. (Medicine) --- Histories, 20th Century --- Histories, Twentieth Century --- History, 20th Cent. (Medicine) --- Twentieth Century Histories --- Twentieth Century History --- Live poliovirus vaccine --- Salk vaccine --- Poliomyelitis --- Health Workforce --- African American colleges --- Afro-American universities and colleges --- Colleges, African American --- HBCUs (Historically black colleges and universities) --- Historically black colleges and universities --- Negro universities and colleges --- Universities and colleges, African American --- Universities and colleges, Black --- Universities and colleges --- History. --- Research --- history --- Prevention --- Tuskegee University --- Tuskegee Institute --- Alabama --- PBIs (Predominantly Black institutions) --- Predominantly Black institutions
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