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Agriculture --- Landbouwkunde --- Poissons --- Sciences appliquées --- Toegepaste wetenschappen --- Visschen --- 637.567.3.025.6 Pl. : 641.1 --- 637.567.3.025.8 Sco : 641.1 --- 641.1 : 637.567.3.0256 Pl. --- 641.1 : 637.567.3.025.8 Sco
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Ask the Grey Sisters: Sault Ste. Marie and the General Hospital, 1898-1998 tells the story of the creation and one-hundred-year history of the Sault Ste. Marie General Hospital. At a time when Canada's healthcare system is at a crossroads and we are asked to make crucial decisions for its future, it is intriguing and enlightening to look at the colourful past of a typical community hospital. Throughout the 1890s, Sault Ste. Marie was a town in search of a hospital. Its glory days at the centre of the fur-trade route were long gone and the Sault was in the process of becoming a
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Security, International --- Regional economics --- Shanghai Cooperation Organisation. --- Asia --- Foreign relations. --- Security, International - Asia --- Regional economics - Asia --- Asia - Foreign relations --- Collective security --- International security --- International relations --- Disarmament --- International organization --- Peace --- Economics --- Regional planning --- Regionalism --- Space in economics --- SCO --- Шанхайская организация сотрудничества --- Shankhaĭskai︠a︡ organizat︠s︡ii︠a︡ sotrudnichestva --- Shanghai Cooperation Organization --- Shanghai Organization of Co-operation --- SOC --- Shanghai he zuo zu zhi --- ШОС --- ShOS
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Ornithology --- Ornithology. --- Society of Canadian Ornithologists --- Society of Canadian Ornithologists. --- Canada. --- Avian biology --- SCO --- Société des ornithologues du Canada --- Canada --- Canadae --- Ceanada --- Chanada --- Chanadey --- Dominio del Canadá --- Dominion of Canada --- Kʻaenada --- Kanada --- Ḳanadah --- Kanadaja --- Kanadas --- Ḳanade --- Kanado --- Kanakā --- Province of Canada --- Republica de Canadá --- Yn Chanadey --- Zoology --- Birds --- Kanak --- Ontario --- Québec --- Canada (Province) --- Dominio del Canad --- Republica de Canad --- Ornithologie --- Periodicals. --- Périodiques. --- Société des ornithologistes du Canada --- Jianada --- Kaineḍā
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The emergence of the Shanghai Cooperation Organisation (SCO) is attracting significant attention from both governments and scholars. Based on fieldwork interviews with officials and experts from its memberstates, this study examines the evolution of the SCO as a regional security provider and a framework for cooperation. In doing so, it challenges current predominant interpretations of the SCO, which portray it as an anti-Western alliance. Instead, Aris suggests that the SCO is focused on addressing intra-regional transnational security challenges perceived as a threat to regime security by its member-states' leaderships. It is also argued that the SCO's loose and non-binding framework for cooperation is proving relatively successful and appropriate for its regional context. On this basis, the book contributes to the development of theory on regionalism beyond the West, emphasising the importance of investigating regional organisations within their regional context.
Security, International --- International agencies --- National security --- Regionalism --- Shanghai Cooperation Organisation --- Asia --- Foreign relations --- #SBIB:327.7H31 --- #SBIB:328H263 --- Human geography --- Nationalism --- Interregionalism --- Associations, International --- IGOs (Intergovernmental organizations) --- Institutions, International --- Intergovernmental organizations --- International administration --- International associations --- International governmental organizations --- International institutions --- International organizations --- International unions --- Organizations, International --- Specialized agencies of the United Nations --- International cooperation --- Interorganizational relations --- Non-state actors (International relations) --- International organization --- Andere intergouvernementele organisaties: WTO, ASEAN e.a. --- Instellingen en beleid: andere GOS-staten --- Shanghai Cooperation Organisation. --- SCO --- Шанхайская организация сотрудничества --- Shankhaĭskai︠a︡ organizat︠s︡ii︠a︡ sotrudnichestva --- Shanghai Cooperation Organization --- Shanghai Organization of Co-operation --- SOC --- Shanghai he zuo zu zhi --- ШОС --- ShOS --- Asia, Central --- Andere intergouvernementele organisaties: WTO, ASEAN e.a --- Inter-governmental organizations --- Security, International - Asia --- International agencies - Asia, Central --- National security - Asia, Central --- Regionalism - Asia, Central --- Asia - Foreign relations - 21st century
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Ang, Gin Wah --- Aoki, Jun --- Architecture Research Office --- Arets, Wiel --- Arima, Hiroyuki --- Ban, Shigeru --- Buildingstudio --- Calleja, Javier --- Central Office of Architecture --- Coenen, Jo --- Coscia, Anthony --- Day, Johnathen --- Einy, Edmund M. --- Elam, Merrill --- Fernau, Richard --- Furuichi, Tetsuo --- Furuya, Nobuaki --- Hartman, Laura --- Hertz, David --- Hobgood , Kenneth --- Holl, Steven --- Irie, Kei'ichi --- Ishiyama, Osamu --- Jackson, Doug --- Jones, Wes --- Joy, Rick --- Kalach, Alberto --- Kappe, Ray --- Kishi, Waro --- Kitagawara, Atsushi --- Kolatan, Sulan --- Kuma, Kengo --- Legorreta, Ricardo --- Lopez Baz, Alfonso --- Mac Donald, William --- Mack, Mark --- Maeda, Norisada --- Maltzan, Michael --- Maselli, Brandes --- Messana, Brian --- Murakami, Toru --- Niles, Edward R. --- O'Rorke, Toby --- Predock, Antoine --- Rosen, Eric --- Rotondi, Michael --- Saitowitz, Stanley --- Scogin, Mack --- SCO Studio --- Sottsass, Ettore --- Takamatsu, Shin --- Techentin, Warren --- Ten Arquitectos --- Urban Fourth
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Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
ferlin --- myoferlin --- dysferlin --- otoferlin --- C2 domain --- plasma membrane --- sulconazole --- NF-κB --- IL-8 --- mammosphere --- breast cancer stem cells --- AF1Q --- MLLT11 --- WNT --- STAT --- esophageal cancer --- prognosis --- mTORC1 --- mTORC2 --- metabolism --- rapalogs --- mTOR inhibitors --- cancer metabolism --- mTOR in immunotherapy --- nutrient metabolism --- kinase inhibitors --- mTOR signaling --- MAPK kinase --- ERK1 --- ERK2 --- CD domain --- Rolled --- SCH772984 --- VRT-11E --- sevenmaker --- cancer therapy --- EMT --- lysosome --- lysosome-mediated invasion --- MZF1 --- phosphorylation --- PAK4 --- SUMOylation --- transcription factor --- zinc finger --- glucocorticoids --- 3D growth --- nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) --- epithelial–mesenchymal transition --- anoikis --- proliferation --- targeted cancer therapy --- disulfiram --- NPL4 --- replication stress --- DNA damage --- BRCA1 --- BRCA2 --- ATR pathway --- PDAC --- TCIRG1 --- ATP6V0a3 --- invasion --- migration --- matrix degradation --- pH-regulation --- autophagy --- multidrug resistance in cancer --- drug efflux pumps --- ATP-binding cassette transporter --- breast cancer resistance protein (BCRP) --- ABCG2 --- pyrazolo-pyrimidine derivative --- SCO-201 --- colorectal cancer --- immunotherapy --- inflammation --- microsatellite instability --- oncofetal chondroitin sulfate --- chondroitin sulfate --- cancer --- solid tumors --- target --- pediatric cancer --- VAR2 --- dexamethasone --- thyroid cancer --- microgravity --- space environment --- n/a --- epithelial-mesenchymal transition
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Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
Research & information: general --- Biology, life sciences --- ferlin --- myoferlin --- dysferlin --- otoferlin --- C2 domain --- plasma membrane --- sulconazole --- NF-κB --- IL-8 --- mammosphere --- breast cancer stem cells --- AF1Q --- MLLT11 --- WNT --- STAT --- esophageal cancer --- prognosis --- mTORC1 --- mTORC2 --- metabolism --- rapalogs --- mTOR inhibitors --- cancer metabolism --- mTOR in immunotherapy --- nutrient metabolism --- kinase inhibitors --- mTOR signaling --- MAPK kinase --- ERK1 --- ERK2 --- CD domain --- Rolled --- SCH772984 --- VRT-11E --- sevenmaker --- cancer therapy --- EMT --- lysosome --- lysosome-mediated invasion --- MZF1 --- phosphorylation --- PAK4 --- SUMOylation --- transcription factor --- zinc finger --- glucocorticoids --- 3D growth --- nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) --- epithelial-mesenchymal transition --- anoikis --- proliferation --- targeted cancer therapy --- disulfiram --- NPL4 --- replication stress --- DNA damage --- BRCA1 --- BRCA2 --- ATR pathway --- PDAC --- TCIRG1 --- ATP6V0a3 --- invasion --- migration --- matrix degradation --- pH-regulation --- autophagy --- multidrug resistance in cancer --- drug efflux pumps --- ATP-binding cassette transporter --- breast cancer resistance protein (BCRP) --- ABCG2 --- pyrazolo-pyrimidine derivative --- SCO-201 --- colorectal cancer --- immunotherapy --- inflammation --- microsatellite instability --- oncofetal chondroitin sulfate --- chondroitin sulfate --- cancer --- solid tumors --- target --- pediatric cancer --- VAR2 --- dexamethasone --- thyroid cancer --- microgravity --- space environment
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The crystal chemistry of spin crossover (SCO) behavior in coordination compounds can potentially be in association with smart materials—promising materials for applications as components of memory devices, displays, sensors and mechanical devices and, especially, actuators, such as artificial muscles. This Special Issue is devoted to various aspects of SCO and related research, comprising 18 interesting original papers on valuable and important SCO topics. Significant and fundamental scientific attention has been focused on the SCO phenomena in a wide research range of fields of fundamental chemical and physical and related sciences, containing the interdisciplinary regions of chemical and physical sciences related to the SCO phenomena. Coordination materials with bistable systems between the LS and the HS states are usually triggered by external stimuli, such as temperature, light, pressure, guest molecule inclusion, soft X-ray, and nuclear decay. Since the first Hofmann-like spin crossover (SCO) behavior in {Fe(py)2[Ni(CN)4]}n (py = pyridine) was demonstrated, this crystal chemistry motif has been frequently used to design Fe(II) SCO materials to enable determination of the correlations between structural features and magnetic properties.
n/a --- hexadentate ligand --- X-ray diffraction --- structural disorder --- lattice energy --- 2-bis(4-pyridyl)ethane --- thermal hysteresis --- optical conductivity spectrum --- spin-state crossover --- solvate --- single crystal --- spin-crossover transition --- spin-crossover --- cobalt oxide --- amorphous --- metal dithiolene complexes --- qsal ligand --- impurity effect --- 3-triazole --- intermolecular interactions --- spin crossover --- hydrogen bonding --- 1 --- 2 --- optical microscopy --- supramolecular coordination polymer --- paramagnetic ligand --- magnetic susceptibility --- high spin --- [Fe(III)(3-OMesal2-trien)]+ --- aminoxyl --- cobalt(II) ion --- mosaicity --- Fe(III) coordination complexes --- nitroxides --- C–H···? interactions --- Fe(II) --- dithiooxalato ligand --- dinuclear triple helicate --- coordination polymers --- magnetization --- spiral structure --- magnetostructural correlations --- charge-transfer phase transition --- structure phase transition --- magnetic properties --- spin polaron --- substitution of 3d transition metal ion --- iron(II) complexes --- X-ray absorption spectroscopy --- coordination complexes --- crystal engineering --- fatigability --- soft X-ray induced excited spin state trapping --- spin transition --- dipyridyl-N-alkylamine ligands --- coordination polymer --- iron (II) --- iron mixed-valence complex --- chiral propeller structure --- spin cross-over (SCO) --- EPR spectroscopy --- Cu(II) complexes --- solvent effects --- ferromagnetism --- SQUID --- LIESST effect --- low spin (LS) --- 57Fe Mössbauer spectroscopy --- dielectric response --- iron(II) --- hetero metal complex --- atropisomerism --- switch --- Schiff base --- counter-anion --- DFT calculation --- Fe(III) complex --- Fe(II) complex --- high spin (HS) --- reaction diffusion --- thermochromism --- supramolecular isomerism --- phase transition --- magnetic transition --- mononuclear --- [Au(dmit)2]? --- UV-Vis spectroscopy --- phase transitions --- ?-? interactions --- [Au(dddt)2]? --- crystal structure --- linear pentadentate ligand --- ion-pair crystals --- C-H···? interactions --- 57Fe Mössbauer spectroscopy
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S10/0523 --- S10/0687 --- S09/0402China: Economics, industry and commerce--Power supply (electricity, mining, oil) and computing industry --- China: Economics, industry and commerce--Asia-China economic relations --- China: Foreign relations and world politics--China and Central Asia --- S09/0402 --- China: Economics, industry and commerce--Power supply (electricity, mining, oil) and computing industry --- Energy policy --- Geopolitics --- Shanghai Cooperation Organisation. --- SCO --- Шанхайская организация сотрудничества --- Shankhaĭskai︠a︡ organizat︠s︡ii︠a︡ sotrudnichestva --- Shanghai Cooperation Organization --- Shanghai Organization of Co-operation --- SOC --- Shanghai he zuo zu zhi --- ШОС --- ShOS --- Asia, Central --- China --- Cina --- Kinë --- Cathay --- Chinese National Government --- Chung-kuo kuo min cheng fu --- Republic of China (1912-1949) --- Kuo min cheng fu (China : 1912-1949) --- Chung-hua min kuo (1912-1949) --- Kina (China) --- National Government (1912-1949) --- China (Republic : 1912-1949) --- People's Republic of China --- Chinese People's Republic --- Chung-hua jen min kung ho kuo --- Central People's Government of Communist China --- Chung yang jen min cheng fu --- Chung-hua chung yang jen min kung ho kuo --- Central Government of the People's Republic of China --- Zhonghua Renmin Gongheguo --- Zhong hua ren min gong he guo --- Kitaĭskai︠a︡ Narodnai︠a︡ Respublika --- Činská lidová republika --- RRT --- Republik Rakjat Tiongkok --- KNR --- Kytaĭsʹka Narodna Respublika --- Jumhūriyat al-Ṣīn al-Shaʻbīyah --- RRC --- Kitaĭ --- Kínai Népköztársaság --- Chūka Jinmin Kyōwakoku --- Erets Sin --- Sin --- Sāthāranarat Prachāchon Čhīn --- P.R. China --- PR China --- Chung-kuo --- Zhongguo --- Zhonghuaminguo (1912-1949) --- Zhong guo --- Chine --- République Populaire de Chine --- República Popular China --- Catay --- VR China --- VRChina --- 中國 --- 中国 --- 中华人民共和国 --- Jhongguó --- Bu̇gu̇de Nayiramdaxu Dundadu Arad Ulus --- Bu̇gu̇de Nayiramdaqu Dumdadu Arad Ulus --- Bu̇gd Naĭramdakh Dundad Ard Uls --- Khi︠a︡tad --- Kitad --- Dumdadu Ulus --- Dumdad Uls --- Думдад Улс --- Kitajska --- China (Republic : 1949- ) --- Central Asia --- Soviet Central Asia --- Tūrān --- Turkestan --- West Turkestan --- Asia --- Foreign relations --- PRC --- P.R.C. --- BNKhAU --- БНХАУ
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