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Disease Models, Animal. --- Hematopoiesis --- Hematopoiesis --- Mice as laboratory animals. --- Mice, SCID --- Immunology. --- Research --- Animal models. --- Immunology.

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Sexuality is considered as a great human value related to happiness and satisfaction, but unfortunately, when affecting mental disorders, they tend to be associated with second level human functions. Nevertheless, sexual dysfunction often accompanies psychiatric disorder, intensely influencing compliance, quality of life and human relationships. Sexuality could be influenced either by a mental disorder itself, difficulties to get and maintain couple relationships or by the use of psychotropic treatments. Treatment-related adverse events are unfortunately under-recognized by clinicians, scarcely spontaneously communicated by patients, and rarely investigated in clinical trials. The most frequent psychotropic compounds that could deteriorate sexuality and quality of life include antidepressants, antipsychotics and mood regulators. There are important differences between them related to some variations in mechanisms of action including serotonin, dopamine and prolactin levels. Little is known about the relevance of sexuality and its dysfunctions in chronic and frequent mental and neurological disorders, such as psychosis, mood disorders, anxiety, phobias, eating disorders, alcohol or drug dependencies, epilepsy and childhood pathology. Poor sexual life, low satisfaction and more frequent risky sex behavior than in the general population are associated with severe mental diseases. There is a need for increasing research in this field, including epidemiological, psychological, neurophysiological, neuroanatomical and genetic variables related to sexual life to get a better understanding of the implicated mechanisms. To increase the sensibility of clinicians, the identification and management of sexual disturbances after the onset of any mental disorder should be highlighted. This would avoid unnecessary suffering and deterioration of quality of life.

online pornography --- addiction --- cybersex --- internet --- compulsive sexual behavior --- hypersexuality --- dopaminergic system --- paroxetine --- agomelatine --- immunohistochemical study --- sexual dysfunction --- male rats --- sexual addiction --- sexual compulsivity --- phenomenology --- comorbidities --- opioid-related disorders --- methadone --- adverse effects --- erectile dysfunction --- medication adherence --- erotic stimulus processing --- serotonin --- noradrenaline --- dopamine --- fMRI --- healthy --- human --- sexual communication anxiety --- sexual perfectionism --- parent-child communication --- risky sexual behavior --- child sexual abuse --- female perpetrator --- mother-child incest --- gender stereotypes --- social taboo --- transgender --- anxiety --- depression --- social loneliness --- romantic loneliness --- autism --- sexual satisfaction --- Asperger syndrome --- sexual desire --- lubrication --- sexual intercourse --- sexual excitation --- sexual inhibition --- post-traumatic stress disorder --- veterans --- predictors --- sexuality --- mental health --- mental disorder --- hidradenitis suppurativa --- sexual abstinence --- partner status --- prison inmates --- eye tracking --- non-consensual image sharing --- intimate images --- objectification --- objectifying gaze --- rape myth acceptance --- sexting --- desvenlafaxine --- antidepressant --- treatment --- prsexdq-salsex questionnaire --- switching strategy --- female sexual dysfunction --- hormonal contraceptive --- libido --- desire --- sex life --- orgasm --- vaginal ring --- depot medroxyprogesterone acetate --- pornography --- delayed ejaculation --- NeMUP --- child sexual offending --- pedophilia --- SCID --- peyronie’s disease --- penile induration --- patient satisfaction --- research

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Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus–virus and virus–host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.

Medicine --- Neurosciences --- spumavirus --- feline illness --- proviral load --- neglected virus --- bovine foamy virus --- infectious clone --- particle release --- cell-free transmission --- foamy virus --- spumaretrovirus --- cross-species virus transmission --- zoonosis --- restriction factors --- immune responses --- FV vectors --- virus replication --- latent infection --- feline foamy virus --- epidemiology --- retrovirus --- Spumaretrovirus --- mountain lion --- Puma concolor --- ELISA --- protease --- reverse transcriptase --- RNase H --- reverse transcription --- antiviral drugs --- resistance --- simian foamy virus --- gibbon --- lesser apes --- co-evolution --- complete viral genome --- equine foamy virus --- isolation --- Japan --- sero-epidemiology --- reptile foamy virus --- endogenous foamy virus --- endogenous retrovirus --- ancient retroviruses --- co-speciation --- foamy virus-host interactions --- viral tropism --- infection --- kidney --- cats --- chronic kidney disease --- chronic renal disease --- integrase --- integration --- co-infections --- NHP --- pathogenesis --- zoonoses --- viral prevalence --- Neotropical primates --- free-living primates --- Brazil --- new world primates --- simian retrovirus --- BFV --- spuma virus --- model system --- animal model --- animal experiment --- miRNA function --- gene expression --- antiviral host restriction --- gene therapy --- in-vivo gene therapy --- hematopoietic stem and progenitor cells --- foamy virus vector --- pre-clinical canine model --- SCID-X1 --- innate sensing --- cGAS --- STING --- foamy viruses --- wild ruminants --- European bison --- red deer --- roe deer --- fallow deer --- seroreactivity --- inter-species transmission --- HSC --- gene marking --- FV gene transfer to HSCs --- gene therapy alternatives --- serotype --- high-throughput sequencing --- replication kinetics --- cytopathic effect --- reverse transcriptase activity --- miRNA expression --- virus-host-interaction --- miRNA target gene identification --- innate immunity --- ANKRD17 --- Bif1 (SH3GLB1) --- replication in vitro --- spumavirus --- feline illness --- proviral load --- neglected virus --- bovine foamy virus --- infectious clone --- particle release --- cell-free transmission --- foamy virus --- spumaretrovirus --- cross-species virus transmission --- zoonosis --- restriction factors --- immune responses --- FV vectors --- virus replication --- latent infection --- feline foamy virus --- epidemiology --- retrovirus --- Spumaretrovirus --- mountain lion --- Puma concolor --- ELISA --- protease --- reverse transcriptase --- RNase H --- reverse transcription --- antiviral drugs --- resistance --- simian foamy virus --- gibbon --- lesser apes --- co-evolution --- complete viral genome --- equine foamy virus --- isolation --- Japan --- sero-epidemiology --- reptile foamy virus --- endogenous foamy virus --- endogenous retrovirus --- ancient retroviruses --- co-speciation --- foamy virus-host interactions --- viral tropism --- infection --- kidney --- cats --- chronic kidney disease --- chronic renal disease --- integrase --- integration --- co-infections --- NHP --- pathogenesis --- zoonoses --- viral prevalence --- Neotropical primates --- free-living primates --- Brazil --- new world primates --- simian retrovirus --- BFV --- spuma virus --- model system --- animal model --- animal experiment --- miRNA function --- gene expression --- antiviral host restriction --- gene therapy --- in-vivo gene therapy --- hematopoietic stem and progenitor cells --- foamy virus vector --- pre-clinical canine model --- SCID-X1 --- innate sensing --- cGAS --- STING --- foamy viruses --- wild ruminants --- European bison --- red deer --- roe deer --- fallow deer --- seroreactivity --- inter-species transmission --- HSC --- gene marking --- FV gene transfer to HSCs --- gene therapy alternatives --- serotype --- high-throughput sequencing --- replication kinetics --- cytopathic effect --- reverse transcriptase activity --- miRNA expression --- virus-host-interaction --- miRNA target gene identification --- innate immunity --- ANKRD17 --- Bif1 (SH3GLB1) --- replication in vitro

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• Reference Manager
• EndNote
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Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus–virus and virus–host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.

Medicine --- Neurosciences --- spumavirus --- feline illness --- proviral load --- neglected virus --- bovine foamy virus --- infectious clone --- particle release --- cell-free transmission --- foamy virus --- spumaretrovirus --- cross-species virus transmission --- zoonosis --- restriction factors --- immune responses --- FV vectors --- virus replication --- latent infection --- feline foamy virus --- epidemiology --- retrovirus --- Spumaretrovirus --- mountain lion --- Puma concolor --- ELISA --- protease --- reverse transcriptase --- RNase H --- reverse transcription --- antiviral drugs --- resistance --- simian foamy virus --- gibbon --- lesser apes --- co-evolution --- complete viral genome --- equine foamy virus --- isolation --- Japan --- sero-epidemiology --- reptile foamy virus --- endogenous foamy virus --- endogenous retrovirus --- ancient retroviruses --- co-speciation --- foamy virus-host interactions --- viral tropism --- infection --- kidney --- cats --- chronic kidney disease --- chronic renal disease --- integrase --- integration --- co-infections --- NHP --- pathogenesis --- zoonoses --- viral prevalence --- Neotropical primates --- free-living primates --- Brazil --- new world primates --- simian retrovirus --- BFV --- spuma virus --- model system --- animal model --- animal experiment --- miRNA function --- gene expression --- antiviral host restriction --- gene therapy --- in-vivo gene therapy --- hematopoietic stem and progenitor cells --- foamy virus vector --- pre-clinical canine model --- SCID-X1 --- innate sensing --- cGAS --- STING --- foamy viruses --- wild ruminants --- European bison --- red deer --- roe deer --- fallow deer --- seroreactivity --- inter-species transmission --- HSC --- gene marking --- FV gene transfer to HSCs --- gene therapy alternatives --- serotype --- high-throughput sequencing --- replication kinetics --- cytopathic effect --- reverse transcriptase activity --- miRNA expression --- virus-host-interaction --- miRNA target gene identification --- innate immunity --- ANKRD17 --- Bif1 (SH3GLB1) --- replication in vitro