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DNA --- Synthesis --- Synthesis. --- DNA Replication --- DNA replication --- Réplication --- DNA Replication. --- 577.213.3 --- Chromosomal DNA replication --- Replication of DNA --- Replication, Autonomous --- Autonomous Replication --- Autonomous Replications --- DNA Replications --- Replication, DNA --- Replications, Autonomous --- Replications, DNA --- DNA-Binding Proteins --- Virus Replication --- S Phase --- biosynthesis. --- Enzymatic synthesis in vitro of DNA, of RNA. DNA-polymerase, RNA-replicase systems --- Replication --- Nucleic Acids --- Nucleic Acids. --- 577.213.3 Enzymatic synthesis in vitro of DNA, of RNA. DNA-polymerase, RNA-replicase systems --- Réplication --- Deoxyribonucleic acid synthesis --- biosynthesis --- Molecular biology --- Basic Sciences. Molecular Biology --- ADN --- Synthèse --- DNA - Synthesis. --- DNA Repair. --- DNA - Synthesis --- DNA Repair --- Deoxyribonucleoproteins --- Enzymes --- Nucleotidyltransferase, deoxyribonucleate --- Plasmids --- Recombination, genetic

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This book includes a collection of eight original research articles and three reviews covering a wide range of topics in the field of kinetoplastids. In addition, readers can find a compendium of molecular biology procedures and bioinformatics tools.

Research & information: general --- Biology, life sciences --- trypanosomatids --- yeasts --- trypanosomatids genome --- cell cycle phases --- S-phase duration --- DNA replication --- replication origins --- neglected tropical diseases --- Leishmania --- Trypanosoma cruzi --- Trypanosoma brucei --- drug discovery --- in vitro models --- in vivo models --- genomics --- drug resistance --- Leishmania infantum --- proteome --- post-translational modifications (PTMs) --- proteogenomics --- mass spectrometry --- Retrotransposon Hot Spot (RHS) multigene family --- chromosome distribution --- recombination --- gene mosaic structure --- evolution --- nuclear protein --- Leishmania braziliensis --- reverse genetics --- CRISPR–Cas9 --- gene targeting --- phenotyping --- heat shock proteins --- Trypanosoma cruzi strain --- sequencing methods --- genome plasticity --- gene expression --- trans-sialidases --- mucins --- SENP --- Ulp2 --- SUMO --- CRISPR --- protease --- genome --- repeats --- 3′UTR --- multigenic family --- Leishmania donovani --- whole-genome sequencing (WGS) --- transcriptome --- artemisinin drug resistance --- Leishmania viruses --- phylogeny --- coevolution --- endosymbiont protozoan viruses --- transcriptome assembly --- transcriptional regulation --- ontology network --- co-expression network --- taxonomic analysis --- database contamination --- kleptoplastidy --- trypanosomatids --- yeasts --- trypanosomatids genome --- cell cycle phases --- S-phase duration --- DNA replication --- replication origins --- neglected tropical diseases --- Leishmania --- Trypanosoma cruzi --- Trypanosoma brucei --- drug discovery --- in vitro models --- in vivo models --- genomics --- drug resistance --- Leishmania infantum --- proteome --- post-translational modifications (PTMs) --- proteogenomics --- mass spectrometry --- Retrotransposon Hot Spot (RHS) multigene family --- chromosome distribution --- recombination --- gene mosaic structure --- evolution --- nuclear protein --- Leishmania braziliensis --- reverse genetics --- CRISPR–Cas9 --- gene targeting --- phenotyping --- heat shock proteins --- Trypanosoma cruzi strain --- sequencing methods --- genome plasticity --- gene expression --- trans-sialidases --- mucins --- SENP --- Ulp2 --- SUMO --- CRISPR --- protease --- genome --- repeats --- 3′UTR --- multigenic family --- Leishmania donovani --- whole-genome sequencing (WGS) --- transcriptome --- artemisinin drug resistance --- Leishmania viruses --- phylogeny --- coevolution --- endosymbiont protozoan viruses --- transcriptome assembly --- transcriptional regulation --- ontology network --- co-expression network --- taxonomic analysis --- database contamination --- kleptoplastidy

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To celebrate its 10th anniversary, the prestigious journal Cells launched a series of Special Issues in 2021. The Special Issue entitled “10th Anniversary of Cells—Advances in Cell Cycle” was launched together with other sister Special Issues under the umbrella “10th Anniversary of Cells.” The cell cycle is a series of events that drives cells to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phases. Cell cycle progression is mediated by cyclin-dependent kinases (CDKs) and their regulatory cyclin subunits. CDKs, such as CDK4/6, CDK2, and CDK1 (also known as CDC2), are serine/threonine kinases with a wide variety of substrates. CDKs are activated mainly by binding to their cyclin partners, whose expressions rise and fall throughout the cell cycle to mediate the temporal activation of each CDKs. Various cell cycle checkpoints exist to ensure that critical processes are engaged prior to progression to the next phase. These cell cycle checkpoints are the G1 (restriction) checkpoint, the G2/M DNA damage checkpoint, and the spindle assembly checkpoint (SAC).This Special Issue attracted the attention of many scientists in the cell cycle field and consists of 10 high quality papers, including four research articles and six scientific reviews: a great success. The four research articles focus on various important topics of the cell cycle using a broad range of model organisms, including yeast, sea urchins, green algae, and human cancer cell lines.

Research & information: general --- Biology, life sciences --- microalgae --- Desmodesmus quadricauda --- cell cycle --- starch --- lipids --- polyphosphate --- guanine --- confocal Raman microscopy --- prenatal life --- perinatal life --- 5-bromo-2′-deoxyuridine --- cerebellar neuroepithelium --- external granular layer --- neurogenetic timetables --- neurogenetic gradients --- apoptosis --- M2 muscarinic receptor --- glioblastoma --- aberrant mitosis --- mitotic spindle --- Leishmania spp. --- leishmaniases --- telomeres --- telomerase --- growth factors --- receptor tyrosine kinases --- G1 phase --- S phase --- G2 phase --- M phase --- Ras/Erk --- PI3K/Akt --- vitelline layer --- fertilization --- sea urchin eggs --- plasticity --- Ca2+ signaling --- actin --- DTT --- TCEP --- BPA-C8-Cy3 --- electron microscopy --- Nud1 --- Cdc15 --- MEN --- mitotic exit --- Dbf2 --- Mob1 --- spindle position checkpoint --- HSF1 --- HSF2 --- cell cycle arrest --- APC/C complex --- CDK --- CTD phosphatase --- RNA polymerase II --- CTD code --- transcription --- LDIR --- hormesis --- cancer --- p21Waf1(CDKN1A) --- n/a --- 5-bromo-2'-deoxyuridine

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The word "cancer" is associated with at least 100 different pathologies, depending on the organ involved and the type of tumor developed. Cancer is a complex disease involving multiple pathogenetic mechanisms. Characterization of different types of cancers, which distinguishes them from healthy cells and other cancers, allows for the identification of specific targets for each individual tumor. The principle of chemotherapy is based on interference with the mechanisms that regulate the life and proliferation of cancer cells, causing their death. In recent years, there has been continuous progress in the development of therapeutic agents against cancer, which is ongoing.The Anticancer Inhibitors Special Issue focuses on new target-based anticancer agents that inhibit a specific target involved in the suppression of various types of cancer and the control of their chemoresistance.There is a collection of research and review articles on advances in drug discovery, design, and development of new inhibitor compounds with potency against various cancer types.

Research & information: general --- Chemistry --- breast cancer --- tamoxifen --- LY294002 --- synergism --- apoptosis --- cell cycle --- tea (Camellia sinensis) flowers --- BTFS --- A2780/CP70 ovarian cancer cells --- S phase cell cycle arrest --- nicotinamide phosphoribosyltransferase --- NAD+ biosynthesis --- inhibitor --- azacyclohexane --- anticancer drug --- drug design --- enthalpy effect --- NSCLC --- Cathepsin K --- cell proliferation --- cell migration --- cell invasion --- mTOR --- isatin-hydrazones --- cytotoxicity --- CDK2 inhibitor --- ATP competitive inhibitor --- ADME analysis --- receptor tyrosine kinases --- protein-protein interactions --- protein engineering --- directed evolution --- angiogenesis --- binding affinity --- agonistic activity --- saponins --- phytochemicals --- tea (Camellia sinensis) flower --- ovarian cancer --- autophagy --- ZMYND8 --- tumorigenesis --- epigenetic regulation --- pro-oncogenic effects --- tumor suppression --- tacrine-coumarin derivatives --- DNA --- topoisomerases I, II --- lung carcinoma cells --- A549 --- chemotherapy --- prodrug --- drug targeting --- overexpressed enzymes --- ADC --- ADEPT --- GDEPT --- LEAPT --- PROTAC --- cyclin-dependent kinase --- cancer --- resistance --- small molecule inhibitors --- PROTACs --- statins --- pancreatic cancer --- DNA microarray --- pitavastatin --- cerivastatin --- simvastatin --- fluvastatin --- atorvastatin --- pravastatin --- HMG-CoA reductase inhibitors --- n/a

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This book includes a collection of eight original research articles and three reviews covering a wide range of topics in the field of kinetoplastids. In addition, readers can find a compendium of molecular biology procedures and bioinformatics tools.

trypanosomatids --- yeasts --- trypanosomatids genome --- cell cycle phases --- S-phase duration --- DNA replication --- replication origins --- neglected tropical diseases --- Leishmania --- Trypanosoma cruzi --- Trypanosoma brucei --- drug discovery --- in vitro models --- in vivo models --- genomics --- drug resistance --- Leishmania infantum --- proteome --- post-translational modifications (PTMs) --- proteogenomics --- mass spectrometry --- Retrotransposon Hot Spot (RHS) multigene family --- chromosome distribution --- recombination --- gene mosaic structure --- evolution --- nuclear protein --- Leishmania braziliensis --- reverse genetics --- CRISPR–Cas9 --- gene targeting --- phenotyping --- heat shock proteins --- Trypanosoma cruzi strain --- sequencing methods --- genome plasticity --- gene expression --- trans-sialidases --- mucins --- SENP --- Ulp2 --- SUMO --- CRISPR --- protease --- genome --- repeats --- 3′UTR --- multigenic family --- Leishmania donovani --- whole-genome sequencing (WGS) --- transcriptome --- artemisinin drug resistance --- Leishmania viruses --- phylogeny --- coevolution --- endosymbiont protozoan viruses --- transcriptome assembly --- transcriptional regulation --- ontology network --- co-expression network --- taxonomic analysis --- database contamination --- kleptoplastidy